التفاصيل البيبلوغرافية
| العنوان: |
Antioxidative and antiproliferative activities of isolated compounds from Prunus domestica: an in vitro study |
| المؤلفون: |
Dhingra, Naveen, Sharma, Rajesh, Kar, Anand |
| المساهمون: |
Department of Science and Technology, New Delhi, India |
| المصدر: |
International Journal of Phytomedicine; Vol 5, No 3 (2013): International Journal of Phytomedicine; 341-346 ; 0975-0185 |
| بيانات النشر: |
AR Journals |
| سنة النشر: |
2013 |
| المجموعة: |
Advanced Research Journals |
| مصطلحات موضوعية: |
Prunus domestica, antioxidant, antiproliferative, DPPH, human breast cancer cell lines |
| الوصف: |
In this investigation the antioxidant as well as antiproliferative activities of different isolated compounds from ethyl acetate fraction of Prunus domestica (peel + flesh) were studied in two human breast cancer cell lines, MCF-7 and MDA-MB-468. Free radical scavengering as done with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) study indicated different degrees of antioxidative activity of the isolated compounds such as chlorogenic acid, protocatechuic acid, vanillic acid, ferulic acid, p-coumaric acid and rutin. However maximum antioxidative activity was observed in chlorogenic acid with IC50 of 0.115 mg/ml. With respect to antiproliferative potential, chlorogenic acid also exhibited the maximum antiproliferative activity on MCF-7 and protocatechuic acid on MDA-MB-468 human breast cancer cell lines. This appears to be the first report that provides a comparative account on the antioxidant and antiproliferative property of some isolated active compounds of the Indian variety of fruit, Prunus domestica. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://www.arjournals.org/index.php/ijpm/article/view/1091/664Test; http://www.arjournals.org/index.php/ijpm/article/view/1091Test |
| الإتاحة: |
http://www.arjournals.org/index.php/ijpm/article/view/1091Test |
| رقم الانضمام: |
edsbas.828DCEB1 |
| قاعدة البيانات: |
BASE |
