التفاصيل البيبلوغرافية
| العنوان: |
The Risk of Developing Non-Alcoholic Fatty Liver Disease in Adult Patients with Subclinical Hypothyroidism Compared to Euthyroid: An Evidence-based Case Report |
| المؤلفون: |
Notariza, Kemas Rakhmat, Wisnu, Wismandari |
| المصدر: |
Acta Medica Indonesiana; Vol 51, No 2 (2019): Acta Medica Indonesiana; 179 ; 23382732 ; 01259326 |
| بيانات النشر: |
Indonesian Society of Internal Medicine |
| سنة النشر: |
2019 |
| المجموعة: |
Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine |
| مصطلحات موضوعية: |
internal medicine, medical journal, endocrinology, euthyroid, non-alcoholic fatty liver disease, subclinical hypothyroidism |
| الوصف: |
Background: hypothyroidism is a common concomitant disease of non-alcoholic fatty liver disease (NAFLD). Previous studies regarding the relationship between subclinical hypothyroidism and NAFLD showed conflicting results, ranging from a strong association to not significant one. This case report aimed to investigate the risk of developing NAFLD in subclinical hypothyroidism patients. Methods: literature searching used ScienceDirect, PubMed, ProQuest, and Scopus. Filtering process of titles and abstracts by using inclusion and exclusion criteria yielded 4 eligible articles (1 systematic review, 1 prospective cohort, 1 retrospective cohort, and 1 case-control study) for answering the clinical question. Critical appraisal was conducted by using worksheets from Centre for Evidence-Based Medicine, University of Oxford. Results: the systematic review was considered invalid due to its less comprehensive search for relevant studies, inappropriate article selection to find a causal relationship between diseases, and statistical heterogeneity. The retrospective cohort was decided unimportant because it possessed a relative risk of 0.85 (95% confidence interval [CI], 0.72--1.00) which the upper limit of its CI included 1.00. The rest were valid and had important risk relative and odds ratio (1.27 [95% CI, 1.09--1.47], 3.41 [95% CI, 1.16--9.98]; respectively). The number needed to harm (5—17) indicated the clinically meaningful harm of the exposure since only a few patients with subclinical hypothyroidism is needed to obtain one additional NAFLD incidence. Those two articles were also suitable to be applied in our case. Conclusion: patients with subclinical hypothyroidism, compared to euthyroid patients, are at higher risk of developing NAFLD. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://www.actamedindones.org/index.php/ijim/article/view/907/pdfTest; http://www.actamedindones.org/index.php/ijim/article/downloadSuppFile/907/664Test; http://www.actamedindones.org/index.php/ijim/article/downloadSuppFile/907/665Test; http://www.actamedindones.org/index.php/ijim/article/downloadSuppFile/907/804Test; http://www.actamedindones.org/index.php/ijim/article/view/907Test |
| الإتاحة: |
http://www.actamedindones.org/index.php/ijim/article/view/907Test |
| حقوق: |
Copyright (c) 2019 Acta Medica Indonesiana |
| رقم الانضمام: |
edsbas.44514944 |
| قاعدة البيانات: |
BASE |
