المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/ Mikrobiyoloji Anabilim Dalı., Çelebi, Solmaz, Hacımustafaoğlu, Mustafa Kemal, Albayrak, Yücehan, Sinirtaş, Ayşe Melda, 7006095295, 6602154166, 36165377200, 54788212600

مصطلحات موضوعية: General & internal medicine, Hepatitis A vaccine, Seroprevalence, Safety, Immunogenicity, Children, Maternal antibody, Infants, Need, Medicine, general & internal, Hepatitis A, Vaccination, Marginal Structural Models, Hepatitis antibody, Immunoglobulin G antibody, Immunoglobulin M antibody, Abdominal discomfort, Adverse outcome, Arthralgia, Article, Child, Child health care, Clinical assessment, Clinical effectiveness, Clinical trial, Controlled study, Drug efficacy, Drug safety, Female

الوصف: Aim: Hepatitis A can be prevented by vaccination. The aim of this study was to determine seropositivity for hepatitis A before vaccination in healthy children 12 and 24 months of age and compare seroconversion rates after vaccination between these 2 groups. Materials and methods: Forty-nine children aged 1 year (Group 1) and 51 children aged 2 years (Group 2) were included in the study. Inactive hepatitis A vaccine (Avaxim, 80 antigenic subtypes, 0.5 mL) were administered to every child in 2 doses, 6 months apart. Anti-hepatitis A virus (HAV) IgG and IgM antibodies were detected by Architect HAVAb-IgG and HAVAb-IgM (Abbott, Wiesbaden, Germany) test kits. Results: Nine percent of the children were seropositive for anti-HAV IgG before vaccination. The seroconversion rate at 2 weeks was 34% and 44% in Group 1 and Group 2, respectively. At 4 weeks the seroconversion rate was 87.7% and 90.1% in Group 1 and Group 2, respectively. All of the children who completed the vaccination program were seropositive at 28 weeks (after the second dose). No serious adverse reaction was observed in any of the children. Conclusion: It was determined that Avaxim, including 80 antigen units, is safe and immunogenic in healthy children 12 and 24 months of age.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Turkish Journal of Medical Sciences; Çelebi, S. vd. (2013). “Assessment of immune responses to hepatitis A vaccination in children aged 1 and 2 years”. Turkish Journal of Medical Sciences, 43(4), 617-624.; https://doi.org/10.3906/sag-1206-99Test; https://journals.tubitak.gov.tr/medical/vol43/iss4/22Test/; http://hdl.handle.net/11452/32855Test; 000323609800022; 2-s2.0-84880940153; 617; 624; 43

الإتاحة: https://doi.org/10.3906/sag-1206-99Test
http://hdl.handle.net/11452/32855Test
https://journals.tubitak.gov.tr/medical/vol43/iss4/22Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/ Mikrobiyoloji Anabilim Dalı., Çelebi, Solmaz, Hacımustafaoğlu, Mustafa Kemal, Albayrak, Yücehan, Sinirtaş, Ayşe Melda, 7006095295, 6602154166, 36165377200, 54788212600

مصطلحات موضوعية: General & internal medicine, Hepatitis A vaccine, Seroprevalence, Safety, Immunogenicity, Children, Maternal antibody, Infants, Need, Medicine, general & internal, Hepatitis A, Vaccination, Marginal Structural Models, Hepatitis antibody, Immunoglobulin G antibody, Immunoglobulin M antibody, Abdominal discomfort, Adverse outcome, Arthralgia, Article, Child, Child health care, Clinical assessment, Clinical effectiveness, Clinical trial, Controlled study, Drug efficacy, Drug safety, Female

الوصف: Aim: Hepatitis A can be prevented by vaccination. The aim of this study was to determine seropositivity for hepatitis A before vaccination in healthy children 12 and 24 months of age and compare seroconversion rates after vaccination between these 2 groups. Materials and methods: Forty-nine children aged 1 year (Group 1) and 51 children aged 2 years (Group 2) were included in the study. Inactive hepatitis A vaccine (Avaxim, 80 antigenic subtypes, 0.5 mL) were administered to every child in 2 doses, 6 months apart. Anti-hepatitis A virus (HAV) IgG and IgM antibodies were detected by Architect HAVAb-IgG and HAVAb-IgM (Abbott, Wiesbaden, Germany) test kits. Results: Nine percent of the children were seropositive for anti-HAV IgG before vaccination. The seroconversion rate at 2 weeks was 34% and 44% in Group 1 and Group 2, respectively. At 4 weeks the seroconversion rate was 87.7% and 90.1% in Group 1 and Group 2, respectively. All of the children who completed the vaccination program were seropositive at 28 weeks (after the second dose). No serious adverse reaction was observed in any of the children. Conclusion: It was determined that Avaxim, including 80 antigen units, is safe and immunogenic in healthy children 12 and 24 months of age.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Turkish Journal of Medical Sciences; Çelebi, S. vd. (2013). “Assessment of immune responses to hepatitis A vaccination in children aged 1 and 2 years”. Turkish Journal of Medical Sciences, 43(4), 617-624.; https://doi.org/10.3906/sag-1206-99Test; https://journals.tubitak.gov.tr/medical/vol43/iss4/22Test/; http://hdl.handle.net/11452/32855Test; 000323609800022; 2-s2.0-84880940153; 617; 624; 43

الإتاحة: https://doi.org/10.3906/sag-1206-99Test
http://hdl.handle.net/11452/32855Test
https://journals.tubitak.gov.tr/medical/vol43/iss4/22Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Alerji ve İmmünoloji Anabilim Dalı., Günaydın, Fatma Esra, HKV-2265-2023, 57210113218

مصطلحات موضوعية: Real-time PCR, Hydroxychloroquine, SARS-CoV-2, Respiratory system, Radiological findings, Clinical features, COVID-19, Angiotensin converting enzyme 2, Arbidol, Bortezomib, C reactive protein, Carfilzomib, Chloroquine, D dimer, Favipiravir, Ferritin, Imatinib, Immunoglobulin G antibody, Immunoglobulin M antibody, Lopinavir plus ritonavir, Remdesivir, Teicoplanin, Adult respiratory distress syndrome, Aerosol, Antihypertensive therapy, Article, Artificial ventilation, Asymptomatic infection, Blood group typing, Bronchoscopy

الوصف: Çalışmada 36 yazar bulunmaktadır. Bu yazarlardan Uludağ Üniversitesi mensuplarının girişleri yapılmıştır. ; The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19. ; Türk Toraks Derneği ; TTS Early Career ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Turkish Thoracic Journal; Yurt içi; Sanayi; Günaydın, F. E. vd. (2020). "What we learned about COVID-19 so far? Notes from underground". Turkish Thoracic Journal, 21(3), 185-192.; https://doi.org/10.5152/TurkThoracJ.2020.20052Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/; http://hdl.handle.net/11452/34377Test; 000540904400009; 2-s2.0-85086933171; 185; 192; 21

الإتاحة: https://doi.org/10.5152/TurkThoracJ.2020.20052Test
http://hdl.handle.net/11452/34377Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Alerji ve İmmünoloji Anabilim Dalı., Günaydın, Fatma Esra, HKV-2265-2023, 57210113218

مصطلحات موضوعية: Real-time PCR, Hydroxychloroquine, SARS-CoV-2, Respiratory system, Radiological findings, Clinical features, COVID-19, Angiotensin converting enzyme 2, Arbidol, Bortezomib, C reactive protein, Carfilzomib, Chloroquine, D dimer, Favipiravir, Ferritin, Imatinib, Immunoglobulin G antibody, Immunoglobulin M antibody, Lopinavir plus ritonavir, Remdesivir, Teicoplanin, Adult respiratory distress syndrome, Aerosol, Antihypertensive therapy, Article, Artificial ventilation, Asymptomatic infection, Blood group typing, Bronchoscopy

الوصف: Çalışmada 36 yazar bulunmaktadır. Bu yazarlardan Uludağ Üniversitesi mensuplarının girişleri yapılmıştır. ; The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19. ; Türk Toraks Derneği ; TTS Early Career ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Turkish Thoracic Journal; Yurt içi; Sanayi; Günaydın, F. E. vd. (2020). "What we learned about COVID-19 so far? Notes from underground". Turkish Thoracic Journal, 21(3), 185-192.; https://doi.org/10.5152/TurkThoracJ.2020.20052Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/; http://hdl.handle.net/11452/34377Test; 000540904400009; 2-s2.0-85086933171; 185; 192; 21

الإتاحة: https://doi.org/10.5152/TurkThoracJ.2020.20052Test
http://hdl.handle.net/11452/34377Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/

المساهمون: Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı., Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı., orcid:0000-0003-1991-8957, Çarlı, Kamil Tayfun, Şen, Ayşin, Batmaz, Hasan, Kennerman, Engin, AAH-1712-2021, E-3867-2010, 6601971539, 7401592869, 6602783183, 16031244000

مصطلحات موضوعية: Biotechnology & applied microbiology, Microbiology, Diagnosis, Infection, Leukosis, Samples, HIV-1, Milk, Animals, Antibodies, viral, Cattle, Enzootic bovine leukosis, Enzyme-linked immunosorbent assay, Immunoglobulin G, Leukemia virus, bovine, Bovine Leukemia Virus, Deltaretrovirus, Immunoglobulin g antibody, Virus antibody, Article, Blood analysis, Enzyme immunoassay, Enzyme linked immunosorbent assay, Nonhuman, Urinalysis

الوصف: Four hundred blood sera from a cattle production unit were tested for BLV-(Bovine Leukaemia Virus) antibody with IP (Institut Porquier) and SE (Svanova Biotech) ELISA kits. Seventy-seven cattle with BLV-antibody (19.25%) and 77 without the antibody were used. No significant difference was found between O.D. of sera of PL + (Persistent Lymphocytosis Positive) and PL-(Negative) cattle. The mean O.D. of urine samples of 77 seropositive cattle was significantly higher than that of 77 seronegative cattle (P < 0.01). There were also differences between urine O.D.s of seropositive (PL +) and seropositive (PL-) groups of cattle with IP (P < 0.05) and SB (P < 0.01) kits. All the results revealed the presence of BLV-antibody in the urine of the cattle without any urinary dysfunction.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Letters in Applied Microbiology; Çarlı, K. T. vd. (1999). "Detection of IgG antibody to Bovine Leukaemia Virus in urine and serum by two enzyme immunoassays". Letters in Applied Microbiology, 28(6), 416-418.; https://doi.org/10.1046/j.1365-2672.1999.00561.xTest; http://hdl.handle.net/11452/25620Test; 000080905700002; 2-s2.0-0033000512; 416; 418; 28

الإتاحة: https://doi.org/10.1046/j.1365-2672.1999.00561.xTest
http://hdl.handle.net/11452/25620Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Gastroenteroloji, Hepatoloji ve Beslenme Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı., orcid:0000-0001-5740-9729, orcid:0000-0002-9726-8219, Erdemir, Gülin, Özkan, Tanju Başarır, Özgür, Taner, Altay, Derya, Çavun, Sinan, Göral, Güher, AAG-8381-2021, AAC-9702-2019, 36015044400, 7004474005, 36087775800, 57009125100, 6507468595, 6603453166

مصطلحات موضوعية: Gastroenterology & hepatology, Microbiology, Childhood, Pylori, Growth, Leptin, Ghrelin, Body-mass index, Growth-factor, Peptic-ulceration, Risk-factors, Stomach, Epidemiology, Malnutrition, Adolescents, Gastritis, Helicobacter Pylori, Duodenum Ulcer, Immunoglobulin G antibody, Somatomedin C, Adolescent, Age distribution, Antibody blood level, Article, Body height, Body weight, Child, Female, Helicobacter infection

الوصف: Background: Helicobacter pylori is associated with gastrointestinal diseases such as gastritis, peptic ulcers, malignancy and lymphoma, and extra-gastrointestinal conditions. H. pylori infection is negatively associated with children's growth. Chronic inflammation of the stomach that results in the loss of appetite and, dysregulation of neuroendocrine hormones such as leptin, and ghrelin are the probable reasons of this negative association. The objective of this study is to determine the serum levels of leptin, ghrelin, and IGF-1 in H. pylori-infected children and their relations with growth. Materials and methodsA hundred and sixty-one school children aged between 6 and 14 years were selected randomly from five primary schools representing a cross section of population. Demographic and sociocultural characteristics, and anthropometric measurements were recorded. Serum H. pylori IgG, insulin-like growth factor-1, leptin, and ghrelin levels were measured in all children. The children were grouped according to the nutritional status and Helicobacter pylori seropositivity. Nutritional indices were compared among groups in association with serum leptin, ghrelin, and insulin-like growth factor-1 levels. Results: H. pylori IgG positivity was found in 34.2%, and 14.9% of children were malnourished. H. pylori seropositivity was significantly higher in older ages (10.32 2.26 vs 9.53 +/- 2.36 years, p = .036), and body weight and height Z scores were significantly lower in H. pylori-seropositive children (-0.33 +/- 1.08 vs 0.04 +/- 1.26, p = .044 and 0.13 +/- 0.92 vs 0.23 +/- 0.91, p = .018 respectively). H. pylori seropositivity was found to be an independent risk factor for shorter body height (p = .01). Serum leptin, ghrelin, and IGF-1 levels were not associated with H. pylori IgG seropositivity (0.35 vs 0.55 ng/mL, p = .3; 3267.4 +/- 753.0 vs 2808.3 +/- 911.4 pg/mL, p = .06; 470 +/- 176 vs 521 +/- 179 ng/mL, p = .32, respectively). Conclusions: Children infected with H. pylori are prone to short stature. This effect ...

العلاقة: Makale - Uluslararası Hakemli Dergi; Helicobacter; Erdemir, G. vd. (2016). "Helicobacter pylori infection in children: Nutritional status and associations with serum Leptin, Ghrelin, and IGF-1 levels". Helicobacter, 21(4), 317-324.; https://doi.org/10.1111/hel.12288Test; http://hdl.handle.net/11452/29522Test; 000380269000008; 2-s2.0-84978049875; 317; 324; 21

الإتاحة: https://doi.org/10.1111/hel.12288Test
http://hdl.handle.net/11452/29522Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Gastroenteroloji, Hepatoloji ve Beslenme Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı., orcid:0000-0001-5740-9729, orcid:0000-0002-9726-8219, Erdemir, Gülin, Özkan, Tanju Başarır, Özgür, Taner, Altay, Derya, Çavun, Sinan, Göral, Güher, AAG-8381-2021, AAC-9702-2019, 36015044400, 7004474005, 36087775800, 57009125100, 6507468595, 6603453166

مصطلحات موضوعية: Gastroenterology & hepatology, Microbiology, Childhood, Pylori, Growth, Leptin, Ghrelin, Body-mass index, Growth-factor, Peptic-ulceration, Risk-factors, Stomach, Epidemiology, Malnutrition, Adolescents, Gastritis, Helicobacter Pylori, Duodenum Ulcer, Immunoglobulin G antibody, Somatomedin C, Adolescent, Age distribution, Antibody blood level, Article, Body height, Body weight, Child, Female, Helicobacter infection

الوصف: Background: Helicobacter pylori is associated with gastrointestinal diseases such as gastritis, peptic ulcers, malignancy and lymphoma, and extra-gastrointestinal conditions. H. pylori infection is negatively associated with children's growth. Chronic inflammation of the stomach that results in the loss of appetite and, dysregulation of neuroendocrine hormones such as leptin, and ghrelin are the probable reasons of this negative association. The objective of this study is to determine the serum levels of leptin, ghrelin, and IGF-1 in H. pylori-infected children and their relations with growth. Materials and methodsA hundred and sixty-one school children aged between 6 and 14 years were selected randomly from five primary schools representing a cross section of population. Demographic and sociocultural characteristics, and anthropometric measurements were recorded. Serum H. pylori IgG, insulin-like growth factor-1, leptin, and ghrelin levels were measured in all children. The children were grouped according to the nutritional status and Helicobacter pylori seropositivity. Nutritional indices were compared among groups in association with serum leptin, ghrelin, and insulin-like growth factor-1 levels. Results: H. pylori IgG positivity was found in 34.2%, and 14.9% of children were malnourished. H. pylori seropositivity was significantly higher in older ages (10.32 2.26 vs 9.53 +/- 2.36 years, p = .036), and body weight and height Z scores were significantly lower in H. pylori-seropositive children (-0.33 +/- 1.08 vs 0.04 +/- 1.26, p = .044 and 0.13 +/- 0.92 vs 0.23 +/- 0.91, p = .018 respectively). H. pylori seropositivity was found to be an independent risk factor for shorter body height (p = .01). Serum leptin, ghrelin, and IGF-1 levels were not associated with H. pylori IgG seropositivity (0.35 vs 0.55 ng/mL, p = .3; 3267.4 +/- 753.0 vs 2808.3 +/- 911.4 pg/mL, p = .06; 470 +/- 176 vs 521 +/- 179 ng/mL, p = .32, respectively). Conclusions: Children infected with H. pylori are prone to short stature. This effect ...

العلاقة: Makale - Uluslararası Hakemli Dergi; Helicobacter; Erdemir, G. vd. (2016). "Helicobacter pylori infection in children: Nutritional status and associations with serum Leptin, Ghrelin, and IGF-1 levels". Helicobacter, 21(4), 317-324.; https://doi.org/10.1111/hel.12288Test; http://hdl.handle.net/11452/29522Test; 000380269000008; 2-s2.0-84978049875; 317; 324; 21

الإتاحة: https://doi.org/10.1111/hel.12288Test
http://hdl.handle.net/11452/29522Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilimdalı., orcid:0000-0003-0463-6818, orcid:0000-0003-0710-5422, orcid:0000-0002-9416-1512, orcid:0000-0001-8571-2581, Karalı, Zuhal, Tanır, Sevgen Başaranoğlu, Karalı, Yasin, Oral, Haluk Barbaros, Kılıç, Sara Şebnem, AAH-1658-2021, K-7285-2012, C-7392-2019, U-2921-2017, 35791967200, 53868381900, 49863694000, 7004498001, 34975059200

مصطلحات موضوعية: Allergy, Immunology, Hepatitis A vaccine, Autoimmunity, ANA, Anti-cardiolipin antibody, Guillain-barre-syndrome, B-Vaccine, Antibodies, Risk, Adolescent, Antibody formation, Autoantibodies, Autoantigens, Child, preschool, Female, Follow-up studies, Hepatitis a vaccines, Humans, Male, Turkey, Vaccination, Pneumococcal Vaccines, Macrophagic Myofasciitis, Antinuclear antibody, Cardiolipin antibody, DNA antibody, Double stranded DNA antibody, Immunoglobulin G antibody

الوصف: Background: Universal vaccination remains the most effective way of preventing the spread of many infectious diseases. Although most adverse effects attributed to vaccines are mild, rare reactions such as autoimmunity do occur. Objectives: We aimed to evaluate the possible role played by hepatitis A vaccine (HAV) in inducing the synthesis of autoantibodies. The study included 40 healthy children vaccinated with 2 doses of HAV at a 6-month interval. The children were investigated for autoantibodies including anti-nuclear antibodies (ANAs), anti smooth muscle antibodies, anti-nDNA, anti-microsomal antibodies, anti-cardiolipin (aCL) immunoglobulin (Ig) M/IgG, anti-ds DNA, ANA profile, and anti neutrophil cytoplasmic antibody profile. Results: One month after the first dose, ANAs at a titer of 1:100 and aCL IgG at 23.7 IgM phospholipid units were detected in 4 children and 1 child, respectively. Of the ANA-positive children, 1 also had ASMA positivity, and another had perinuclear and cytoplasmic ANCA positivity. After the second dose, 3 of the children had aCL IgM. In addition, 2 distinct children had positive anti-thyroid microsomal antibodies and ANA after the second dose. The presence of these autoantibodies following vaccination was statistically significant (P=.002). At month 12 of the study, only 2 children continued to be ANA-positive at the same titer as after the first vaccine dose. Conclusions: Although HAV can induce the production of autoantibodies, none of the children developed autoimmune disorders. Longterm follow up is necessary to check whether autoimmune disorders develop in children who still have ANA. Genetic, immunological, environmental, and hormonal factors are also important in the development of vaccine-induced autoimmunity.

العلاقة: Makale - Uluslararası Hakemli Dergi; Journal of Investigational Allergology and Clinical Immunology; Karalı, Z. vd. (2011). "Autoimmunity and hepatitis a vaccine in children". Journal of Investigational Allergology and Clinical Immunology, 21(5), 389-393.; https://pubmed.ncbi.nlm.nih.gov/21905502Test/; http://hdl.handle.net/11452/23923Test; 000295388600007; 2-s2.0-80051775112; 389; 393; 21

الإتاحة: http://hdl.handle.net/11452/23923Test
https://pubmed.ncbi.nlm.nih.gov/21905502Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı., Kaya, Tülay Eken, Ozan, Hakan, Özakın, Cüneyt, 55108697800, 7003908072, 57200678942

مصطلحات موضوعية: Cervix, Helicobacter pylori, Infection, Cancer, Transmission, Association, Prevalence, Risk, Obstetrics & gynecology, Adult, Cervical intraepithelial neoplasia, Female, Helicobacter infections, Humans, Serologic tests, Uterine cervical neoplasms, Young adult, Gastritis, Duodenum Ulcer, Immunoglobulin A antibody, Immunoglobulin G antibody, Article, Clinical article, Cryotherapy, Cytology, Electrosurgery, Enzyme linked immunosorbent assay, Feces analysis, Helicobacter infection, Human

الوصف: Purpose: Helicobacter pylori (H. pylori) is believed to play a role in several gynecological and obstetric pathologies since the cervical mucosa resembles the gastric environment. The microorganism is expected to infect the upper genital tract via the oral-genital and fecal-genital routes. Methods: We studied 35 cases with benign, ASCUS, ASC-H, LSIL and HSIL pap-smear results. The presence of H. pylori in the uterine cervix and active infection were investigated with the H. pylori stool antigen test. Biopsy specimens were stained with hemnatoxylin-eosin and Warthin-Starry stains to find H. pylori in cervical tissue. Seroprevalence was investigated by using ELISA for H. pylori IgG and IgA. Results: The H. pylori seroprevalence was 65.7%; further, 17.1% of the cases had an active infection. H. pylori was not found in the cervix or the cervicovaginal secretions. Conclusion: The cervix is not a reservoir for H. pylori, and the microorganism does not appear to be transmitted through the fecal-genital route.

العلاقة: Makale - Uluslararası Hakemli Dergi; Clinical and Experimental Obstetrics and Gynecology; Kaya, T. vd. (2009). "The presence of Helicobacter pylori in cervical preinvasive lesions". Clinical and Experimental Obstetrics and Gynecology, 36(2), 113-115.; http://hdl.handle.net/11452/24737Test; 000266881700014; 2-s2.0-67649790381; 113; 115; 36

الإتاحة: http://hdl.handle.net/11452/24737Test

المؤلفون: Küçükerdoǧan, Aygün

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı., orcid:0000-0002-2382-290X, Hacımustafaoğlu, Mustafa Kemal, Çelebi, Solmaz, Aynacı, E., Sınırtaş, Melda, Köksal, Nilgün, Ercan, İlker, Göral, Güher, Ildırım, İbrahim, 6602154166, 7006095295, 35232391400, 6505818048, 7003323615, 6603789069, 6603453166, 6602734989

مصطلحات موضوعية: Pediatrics, Syncytial virus-infection, Infants, Age, Antibodies, anti-idiotypic, viral, Female, Humans, Immunity, maternally-acquired, Infant, newborn, Male, Pregnancy, Pregnancy complications, infectious, Respiratory syncytial virus infections, Respiratory syncytial viruses, Human Respiratory Syncytial Virus, Viral Fusion Proteins, Pneumovirus, Immunoglobulin G, Immunoglobulin G antibody, Maternal antibody, Neutralizing antibody, Virus vaccine, Antibody blood level, Antibody detection, Blood sampling

الوصف: The concentrations of maternal anti-RSV IgG antibodies were followed in 49 healthy newborns over the first six months of life. At birth, 41 mothers (83%) tested positive for anti-RSV IgG and all of their babies carried maternal anti-RSV IgG. Anti-RSV IgG positivity dropped to 73% at 1 month, 6% at 3 months, and 2% at 6 months. Between 3 and 6 months, 8% did acquire RSV infection, half of them as acute bronchiolitis and half as non-specific respiratory infection. All of the patients who acquired clinical RSV disease had an antibody concentration of <20 RU/ml which may be the cut off value for protection.

العلاقة: Makale - Uluslararası Hakemli Dergi; Archives of Disease in Childhood; Yurt içi; Küçükerdoǧan, A. vd. (2004). “The progression of maternal RSV antibodies in the offspring”. Archives of Disease in Childhood, 89(1), 52-53.; https://doi.org/10.1136/adc.2002.017780Test; https://adc.bmj.com/content/89/1/52Test; http://hdl.handle.net/11452/21887Test; 000187890400019; 2-s2.0-1642580628; 52; 53; 89

الإتاحة: https://doi.org/10.1136/adc.2002.017780Test
http://hdl.handle.net/11452/21887Test
https://adc.bmj.com/content/89/1/52Test