المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., orcid:0000-0002-6067-3886, Varal, İpek Güney, Köksal, Nilgün, Özkan, Hilal, Bağcı, Onur, Doğan, Pelin, AAG-8393-2021, AAI-5981-2020, 57197818259, 15056452900, 16679325400, 20733563300, 55316686500

مصطلحات موضوعية: General & internal medicine, Neurodevelopment, Newborn, Synbiotics, Brain-development, Preterm infants, Probiotics, Premature, Growth, System, Medicine, general & internal, Intestine Flora, Ruminococcaceae, Microorganisms, Prebiotic agent, Probiotic agent, Synbiotic agent, Article, Body weight, Brain growth, Central nervous system, Chemical composition, Clinical effectiveness, Controlled study, Female, Gestational age, Head circumference, Human, Infant

الوصف: Background & Objective: Preterm infants need nutritional and medical requirements in accordance with the physiologic maturity at birth and maintaining optimal postnatal corporal and cerebral growth is one of the main targets of medical caregivers. However, only a few strategies exist to improve the outcomes of infants in a pathogen-rich and nutrient-poor neonatal intensive care unit environment. In this pilot study, we hypothesize that synbiotics may enhance brain growth, which is reflected indirectly by an increase in head circumference through several signalling molecules. Methods: A pilot study was conducted in preterm infants with a gestational age of <= 32 weeks and a birth weight of <= 1500 grams at neonatal intensive care unit of Uludag Univeristy Medical Faculty (NICU) for one-year period. Following the randomization of the infants, a prepared commercial synbiotic solution containing multi-combined probiotics and prebiotics was administered enterally to the study group. Results: The odds of a patient having a lower body weight and head circumference below the 10th percentile were significantly lower in the probiotic group (p=0.001, p=0.03, respectively). Moreover, the infants in the synbiotics group had a more optimal head circumference (between the 50th and 90th percentiles, p=0.001). Conclusions: Our results show that if we can maintain optimal gut microbiota, we might achieve better neuro-development via the beneficial effects of synbiotics on cytokines, neurotransmitters, and the cellular immunity of the nervous system. Further investigational models are needed to demonstrate the beneficial effects of synbiotics on the central nervous system.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Pakistan Journal of Medical Sciences; Varal, İ. G. vd. (2018). ''Potential use of multi-strain synbiotics for improving postnatal head circumference''. Pakistan Journal of Medical Sciences, 34(6), 1502-1506.; https://doi.org/10.12669/pjms.346.16107Test; https://pjms.com.pk/index.php/pjms/article/view/16107Test; http://hdl.handle.net/11452/34277Test; 000464432600036; 2-s2.0-85057002303; 1502; 1506; 34

الإتاحة: https://doi.org/10.12669/pjms.346.16107Test
http://hdl.handle.net/11452/34277Test
https://pjms.com.pk/index.php/pjms/article/view/16107Test

المؤلفون: Pedrinolla, Anna, Venturelli, Massimo, Moschetta, Federica, Zardini, Monica, Rudi, Doriana, Bacchi, Elisabetta, Schena, Federico, Moghetti, Paolo, Lanza, Massimo

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Kırmızı, Emine, 57205595616

مصطلحات موضوعية: Immunology, Physical-activity, Skeletal-muscle, Adipose-tissue, Older-adults, Men, Impairment, Capacity, Diet, Adiposity, Aged, Aging, Angioplasty, balloon, Blood pressure determination, C-reactive protein, Cytokines, Exercise, Female, Humans, Inflammation, Inflammation mediators, Male, Obesity, Vascular diseases, C Reactive Protein, Waist Circumference, Body Mass, Antacid agent, C reactive protei

الوصف: In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile. Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases. Nonetheless, its long-term effect on vascular function and inflammation in age-related obesity is still unclear. The aim of this study was to investigate the effect of regular, supervised exercise on inflammatory profile and vascular function in age-related obesity. We also hypothesized that vascular function and inflammatory profile would have been correlated in overweight and obese individuals. Thirty normal weight (NW; 70 +/- 5 years, 23.9 +/- 2.6 BMI) and forty overweight and obese elderly (OW & OB; 69 +/- 5 years, 30.1 +/- 2.3 BMI) regularly taking part in a structured, supervised exercise program were enrolled in the study and evaluated for vascular function (flow-mediated dilation; FMD) and inflammatory profile (plasma CRP, IL-1 beta, IL-1ra, IL-6, IL-8, IL-10, TNF-alpha, and MCP-1). Although no differences between groups were found concerning performance and the weekly amount of physical activity, the OW&OB group compared with the NW group demonstrated higher systolic and diastolic blood pressure (10%, p = 0.001; +9%, p = 0.005, respectively); lower FMD% (-36%, p < 0.001) and FMD/shear rate (-40%, p = 0.001); and higher levels of CRP (+33%, p = 0.005), IL-6 (+36%, p = 0.048), MCP-1 (+17%, p = 0.004), and TNF-alpha (+16%, p = 0.031). No correlations between vascular function and inflammation were found in OW&OB or NW. Although exercising regularly, overweight and obese elderly exhibited poorer vascular function and higher proinflammatory markers compared with the leaner group. These results support the idea that exercise alone cannot counteract the negative effect of adiposity on vascular function and inflammatory profile in elderly individuals and these two processes are not necessarily ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Journal of Immunology Research; Yurt dışı; Sanayi; Pedrinolla, A. vd. (2018). ''Role of exercise in vascular function and inflammatory profile in age-related obesity''. Journal of Immunology Research, 2018.; https://doi.org/10.1155/2018/7134235Test; https://www.hindawi.com/journals/jir/2018/7134235Test/; http://hdl.handle.net/11452/34683Test; 000449834100001; 2-s2.0-85060713276; 2018

الإتاحة: https://doi.org/10.1155/2018/7134235Test
http://hdl.handle.net/11452/34683Test
https://www.hindawi.com/journals/jir/2018/7134235Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı., orcid:0000-0002-6067-3886, Varal, İpek Güney, Köksal, Nilgün, Özkan, Hilal, Bağcı, Onur, Doğan, Pelin, AAG-8393-2021, AAI-5981-2020, 57197818259, 15056452900, 16679325400, 20733563300, 55316686500

مصطلحات موضوعية: General & internal medicine, Neurodevelopment, Newborn, Synbiotics, Brain-development, Preterm infants, Probiotics, Premature, Growth, System, Medicine, general & internal, Intestine Flora, Ruminococcaceae, Microorganisms, Prebiotic agent, Probiotic agent, Synbiotic agent, Article, Body weight, Brain growth, Central nervous system, Chemical composition, Clinical effectiveness, Controlled study, Female, Gestational age, Head circumference, Human, Infant

الوصف: Background & Objective: Preterm infants need nutritional and medical requirements in accordance with the physiologic maturity at birth and maintaining optimal postnatal corporal and cerebral growth is one of the main targets of medical caregivers. However, only a few strategies exist to improve the outcomes of infants in a pathogen-rich and nutrient-poor neonatal intensive care unit environment. In this pilot study, we hypothesize that synbiotics may enhance brain growth, which is reflected indirectly by an increase in head circumference through several signalling molecules. Methods: A pilot study was conducted in preterm infants with a gestational age of <= 32 weeks and a birth weight of <= 1500 grams at neonatal intensive care unit of Uludag Univeristy Medical Faculty (NICU) for one-year period. Following the randomization of the infants, a prepared commercial synbiotic solution containing multi-combined probiotics and prebiotics was administered enterally to the study group. Results: The odds of a patient having a lower body weight and head circumference below the 10th percentile were significantly lower in the probiotic group (p=0.001, p=0.03, respectively). Moreover, the infants in the synbiotics group had a more optimal head circumference (between the 50th and 90th percentiles, p=0.001). Conclusions: Our results show that if we can maintain optimal gut microbiota, we might achieve better neuro-development via the beneficial effects of synbiotics on cytokines, neurotransmitters, and the cellular immunity of the nervous system. Further investigational models are needed to demonstrate the beneficial effects of synbiotics on the central nervous system.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Pakistan Journal of Medical Sciences; Varal, İ. G. vd. (2018). ''Potential use of multi-strain synbiotics for improving postnatal head circumference''. Pakistan Journal of Medical Sciences, 34(6), 1502-1506.; https://doi.org/10.12669/pjms.346.16107Test; https://pjms.com.pk/index.php/pjms/article/view/16107Test; http://hdl.handle.net/11452/34277Test; 000464432600036; 2-s2.0-85057002303; 1502; 1506; 34

الإتاحة: https://doi.org/10.12669/pjms.346.16107Test
http://hdl.handle.net/11452/34277Test
https://pjms.com.pk/index.php/pjms/article/view/16107Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı., orcid:0000-0003-0710-5422, orcid:0000-0003-4402-9609, Sağlam, Halil, Erdöl, Şahin, Dorum, Sevil, C-7392-2019, 35612700100, 54419947800, 41661166200

مصطلحات موضوعية: Endocrinology & metabolism, Pediatrics, Hypophosphatasia, Turkish children, Alkaline-phosphatase gene, Mutations, Adult, Child, Female, Genotype, Humans, Male, Retrospective studies, Turkey, Asfotase Alfa, Alkaline Phosphatase, Adolescent, ALPL gene, Article, Assisted ventilation, Autosomal recessive disorder, Bone mineralization, Bone radiography, Chest circumference, Clinical article, Clinical assessment, Controlled study, Deciduous tooth, DNA sequence, Dual energy X ray absorptiometry

الوصف: Objective: Hypophosphatasia (HPP) is a rare, commonly unrecognized hereditary mineralization defect with a dramatically poor prognosis in severe cases. This study is the first to examine the detailed clinical and laboratory characteristics of patients with HPP and healthy carriers in Turkey. Methods: The study data were obtained retrospectively from the files of 10 healthy carriers and of 16 cases with HPP (12 children and 4 adults) who were followed in our center from 2012 to 2016. Results: The annual incidence of perinatal lethal hypophosphatasia (PLH) was estimated to be approximately 1 case per 435,517 live births,, which is the first report from Turkey. The clinical courses of the cases differed depending on the type of HPP. All of the seven cases (58.3% of all cases) with perinatal lethal form of HPP died. A need for respiratory support (p = 0.001), a history of pyridoxine-dependent seizures (p = 0.001), a low chest circumference measurement (p = 0.017), younger age at diagnosis (p = 0.029), a small head circumference at the time of presentation (p = 0.042), a low arm span to height ratio (p = 0.048), and a low serum alkaline phosphatase (ALP) level (p = 0.042) seemed to be predicting factors for mortality. The mean height standard deviation score of the patients and those of the healthy carriers did not differ significantly (p = 0.173). Different mutations were detected in nine of 14 cases (64.2%) in whom an ALPL gene mutation analysis could be performed, and five of these cases (35.7%) had novel mutations. The most common mutations were c746G>T (five alleles), c346G>A (three alleles), and c.140C>T (three alleles). In addition, the most frequently observed genotype in Turkish HPP cases was autosomal-dominant c.346G>A (p.A116T) mutations which were detected in three cases in two different families. Conclusion: Because of the respiratory problems, especially the lung hypoplasia, the clinical course is poor in cases with the perinatal lethal form of HPP. Some minor abnormalities such as mild ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; 2016-19/13; JCRPE Journal of Clinical Research in Pediatric Endocrinology; Sağlam, H. vd. (2017). ''Clinical and genetic findings of Turkish hypophosphatasia cases''. JCRPE Journal of Clinical Research in Pediatric Endocrinology, 9(3), 229-236.; https://doi.org/10.4274/jcrpe.4549Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596804Test/; http://hdl.handle.net/11452/30547Test; 000410406300007; 2-s2.0-85029042566; 229; 236

الإتاحة: https://doi.org/10.4274/jcrpe.4549Test
http://hdl.handle.net/11452/30547Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596804Test/

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı., orcid:0000-0003-0710-5422, orcid:0000-0003-4402-9609, Sağlam, Halil, Erdöl, Şahin, Dorum, Sevil, C-7392-2019, 35612700100, 54419947800, 41661166200

مصطلحات موضوعية: Endocrinology & metabolism, Pediatrics, Hypophosphatasia, Turkish children, Alkaline-phosphatase gene, Mutations, Adult, Child, Female, Genotype, Humans, Male, Retrospective studies, Turkey, Asfotase Alfa, Alkaline Phosphatase, Adolescent, ALPL gene, Article, Assisted ventilation, Autosomal recessive disorder, Bone mineralization, Bone radiography, Chest circumference, Clinical article, Clinical assessment, Controlled study, Deciduous tooth, DNA sequence, Dual energy X ray absorptiometry

الوصف: Objective: Hypophosphatasia (HPP) is a rare, commonly unrecognized hereditary mineralization defect with a dramatically poor prognosis in severe cases. This study is the first to examine the detailed clinical and laboratory characteristics of patients with HPP and healthy carriers in Turkey. Methods: The study data were obtained retrospectively from the files of 10 healthy carriers and of 16 cases with HPP (12 children and 4 adults) who were followed in our center from 2012 to 2016. Results: The annual incidence of perinatal lethal hypophosphatasia (PLH) was estimated to be approximately 1 case per 435,517 live births,, which is the first report from Turkey. The clinical courses of the cases differed depending on the type of HPP. All of the seven cases (58.3% of all cases) with perinatal lethal form of HPP died. A need for respiratory support (p = 0.001), a history of pyridoxine-dependent seizures (p = 0.001), a low chest circumference measurement (p = 0.017), younger age at diagnosis (p = 0.029), a small head circumference at the time of presentation (p = 0.042), a low arm span to height ratio (p = 0.048), and a low serum alkaline phosphatase (ALP) level (p = 0.042) seemed to be predicting factors for mortality. The mean height standard deviation score of the patients and those of the healthy carriers did not differ significantly (p = 0.173). Different mutations were detected in nine of 14 cases (64.2%) in whom an ALPL gene mutation analysis could be performed, and five of these cases (35.7%) had novel mutations. The most common mutations were c746G>T (five alleles), c346G>A (three alleles), and c.140C>T (three alleles). In addition, the most frequently observed genotype in Turkish HPP cases was autosomal-dominant c.346G>A (p.A116T) mutations which were detected in three cases in two different families. Conclusion: Because of the respiratory problems, especially the lung hypoplasia, the clinical course is poor in cases with the perinatal lethal form of HPP. Some minor abnormalities such as mild ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; 2016-19/13; JCRPE Journal of Clinical Research in Pediatric Endocrinology; Sağlam, H. vd. (2017). ''Clinical and genetic findings of Turkish hypophosphatasia cases''. JCRPE Journal of Clinical Research in Pediatric Endocrinology, 9(3), 229-236.; https://doi.org/10.4274/jcrpe.4549Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596804Test/; http://hdl.handle.net/11452/30547Test; 000410406300007; 2-s2.0-85029042566; 229; 236

الإتاحة: https://doi.org/10.4274/jcrpe.4549Test
http://hdl.handle.net/11452/30547Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596804Test/

المؤلفون: Billur, Deniz, Kızıl, Şule, Aydın, Sevim, Ünlü, Ağahan

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., orcid:0000-0001-5472-9065, Taşkapılıoğlu, M. Ozgur, Taşkapılıoğlu, Özlem, Ocakoğlu, Gökhan, Bekar, Ahmet, HLG-6346-2023, AAK-6623-2020, ABB-8161-2020, AAH-5180-2021, AAW-5254-2020, 25936798300, 23037226400, 15832295800, 6603677218

مصطلحات موضوعية: Neurosciences & neurology, Surgery, Chick embryo, Glatiramer acetate, FOXP, N-Cadherin, Spinal cord development, Transcription factor foxp3, B-cell lymphoma, Multiple-sclerosis, Immune-responses, Pregnant-women, Fork head, T-cells, Defects, Expression, Genes, Animals, Apoptosis, Cadherins, Chickens, Embryonic development, Forkhead transcription factors, Neural tube, Neural tube defects, Repressor proteins, Clinical neurology, Cadmium, Head Circumference, Eutheria

الوصف: AIM: To demonstrate the effect of glatiramer acetate (GA) in chick embryos on neural tube (NT) development, and to explore its effects of FOXP1, apoptosis, and N-cadherin. MATERIAL and METHODS: One hundred fertile, specific pathogen free eggs were divided into 5 groups for this study. The eggshell was windowed specifically at 24 hours of incubation. The embryos in Group 1 (n=20) were treated with 10 mu l physiological saline; in Group 2 the embryos (n=20) were given 10 mu l GA (equal to daily human therapeutic dose); 20 mu l GA (equal to twice daily human therapeutic dose) was injected to embryos in Group 3 (n=20); in Group 4 and 5, 30 mu l and 40 mu l GA were administered to the embryos (n=20) (equal to x3 and x4 daily human therapeutic dose, respectively). Each egg was re-incubated for 24 hours more. Then, histological and immunohistochemical evaluation of the subjects were done. RESULTS: The embryos with NT defect showed FOXP1 expression without N-cadherin or staining with N-cadherin in another location in our study. We interpreted this result as GA leading to an NT closure defect by increasing FOXP expression. Moreover, we also showed the reverse relation between FOXP1 and N-cadherin at the immunohistochemical level for the first time. CONCLUSION: GA affects the spinal cord development through FOXP in the chick embryo model at high doses.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Turkish Neurosurgery; Yurt içi; Taşkapılıoğlu, M. Ö. vd. (2016). "Targeting apoptosis through FOXP1, and N-cadherin with glatiramer acetate in chick embryos during neural tube development". Turkish Neurosurgery, 26(4), 586-594.; https://doi.org/10.5137/1019-5149.JTN.14518-15.3Test; http://www.turkishneurosurgery.org.tr/abstract.php?id=1726Test; http://hdl.handle.net/11452/31550Test; 000381591600018; 2-s2.0-85021855641; 586; 594; 26

الإتاحة: https://doi.org/10.5137/1019-5149.JTN.14518-15.3Test
http://hdl.handle.net/11452/31550Test
http://www.turkishneurosurgery.org.tr/abstract.php?id=1726Test

المؤلفون: Kıyıcı, Sinem, Koca, Nizameddin, Aslan, Bilal Burçak, Güçlü, Metin, Kısakol, Gürcan

المساهمون: Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Sığırlı, Deniz, AAA-7472-2021, 24482063400

مصطلحات موضوعية: Obesity, Food addiction, Depression, Metabolic parameters, Insulin resistance, Turkish version, Short-form, Scale, Prevelance, Weight, Energy, Assocaition, Reliability, Severity, Research & experimental medicine, Adult, Anthropometry, Body composition, Body mass index, Exercise, Feeding behavior, Female, Humans, Male, Middle aged, Neuropsychological tests, Patient Acceptance of Health Care, Psychosocial functioning, Quality of life, Waist circumference

الوصف: Aim: To investigate the association of food addiction (FA) with the psychosocial functioning and metabolic parameters in obese patients seeking weight-loss treatment. Methods: Two hundred twenty-four obese patients (male/female: 28/196) with a mean age of 44.5 ± 13.4 years and body mass index (BMI) of 41.6 ± 7.2 were included in the study. After receiving sociodemographic data and medical history, detailed physical examination, including anthropometric measurements, was performed by an experienced physician. Blood samples were taken after 8-12 hr of fasting. The presence of FA was evaluated by using Yale Food Addiction Scale (YFAS). Psychological evaluation was performed by using a self-reported Patient Health Questionnaire-9 (PHQ-9) and health-related quality of life using the 36-item short-form health survey (SF-36). Results: Seventy-two of 224 (32.1%) patients met the criteria for FA, according to YFAS. The mean age of patients with FA was younger compared with patients without FA (P < 0.001). There was no statistically significant difference between the patients with and without FA in terms of BMI, fat percentage, and waist circumference (P = 0.440, P = 0.644, and P = 0.144, respectively). The depression frequency was significantly higher (61.1%, P < 0.001), while the SF-36 score of mental health was lower (P = 0.027) in patients with FA than in the patients without FA. Age-and sex-adjusted mean fasting plasma glucose level was lower in patients with FA (P = 0.021), but serum insulin levels, HOMA-IR (homeostasis model assessment of insulin resistance), HbA1c (hemoglobin A1c), lipid parameters, and vascular adiposity index were comparable. Conclusions: We found that FA frequency was very high in obese patients seeking treatment for weight loss, and it correlates with psychosocial functioning more than metabolic parameters.

العلاقة: Makale - Uluslararası Hakemli Dergi; Metabolic Syndrome and Related Disorders; Sanayi; Kıyıcı, S. vd. (2020). "Food addiction correlates with psychosocial functioning more than metabolic parameters in patients with obesity". Metabolic Syndrome and Related Disorders, 18(3), 161-167.; https://hdl.handle.net/11452/39461Test; 000512334300001; 2-s2.0-85083042251; 161; 167; 18; https://doi.org/10.1089/met.2019.0108Test

الإتاحة: https://doi.org/10.1089/met.2019.0108Test
https://hdl.handle.net/11452/39461Test

المؤلفون: Demirci, Hakan, Çınar, Yıldırım

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı., Bilgel, Nazan, 7801564702

مصطلحات موضوعية: Pharmacology & pharmacy, Psychiatry, Metabolic syndrome, Adult population, Depressive symptoms, Family practice, Turkey, Cholesterol levels, Young-adults, Older men, Association, Risk, Anxiety, Cooccurrence, Prevalence, Obesity, Metabolik sendrom, Adult popülasyon, Depresif semptomlar, Aile hekimliği, Türkiye, Waist Circumference, Abdominal Obesity, Glucose, High density lipoprotein cholesterol, Triacylglycerol, Adult, Aged, Article, Beck depression inventory

الوصف: Background: The possible association between depressive symptoms and metabolic syndrome (MetS) has recently become an important topic of discussion. There is some limited and inconsistent evidence in the literature concerning whether or not depression and metabolic syndrome are associated. The aim of this study was to examine the association between depressive symptoms and metabolic syndrome. Methods: This is a cross-sectional community-based study. The setting is a family practice unit in an urban area which serves about 3,600 people. The participants were 250 individuals aged 18 and over, selected randomly from all enrolled patients in this family practice unit. National Cholesterol Education Program (NCEP- ATP-III) criteria were used for the classification of metabolic myndrome (MetS). The Beck Depression Inventory was filled out by the participants for the evaluation of depressive symptoms. Results: The prevalence of MetS was similar for men (48.8%) and women (48.1%) and increased with age in both sexes. Participants with only primary education were found to be 2.2 times more at risk of developing MetS than participants with a higher education. The prevalence of depressive symptoms was higher among women (31.0%) than men (9.9%). Statistical analyses revealed no statistically significant association between MetS and depressive symptoms. Conclusion: The prevalence of MetS was found to be high in both sexes. Women had a 3.8 times higher risk of developing depressive symptoms than men. We found no association of depressive symptoms with MetS or with any of the MetS criteria. ; Depresif semptomlar ve metabolik sendrom (MetS) arasındaki muhtemel ilişki son dönemde önemli bir tartışma konusudur. Bu ilişkinin varlığı konusunda sınırlı veri vardır. Bu çalışmanın amacı depresyon ve MetS arasındaki ilişkiyi incelemektir. Yöntem: Bu çalışma toplum kökenli kesitsel bir çalışmadır. Çalışma 3600 kişiden sorumlu kentsel bir aile hekimliği biriminde yürütülmüştür. Çalışmaya katılanlar bu aile hekimliği ünitesine başvuran 18 ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Klinik Psikofarmakoloji Bülteni; Yurt içi; Sanayi; Demirci, H. vd. (2011). "Metabolic syndrome and depressive symptoms in a primary health care setting in Turkey". Klinik Psikofarmakoloji Bülteni, 21(1), 49-57.; https://doi.org/10.5350/kpb-bcp201121108Test; https://psychiatry-psychopharmacology.com/en/metabolic-syndrome-and-depressive-symptoms-in-a-primary-health-care-setting-in-turkey-131485Test; http://hdl.handle.net/11452/24064Test; 000290364100008; 2-s2.0-79955579596; 49; 57; 21

الإتاحة: https://doi.org/10.5350/kpb-bcp201121108Test
http://hdl.handle.net/11452/24064Test
https://psychiatry-psychopharmacology.com/en/metabolic-syndrome-and-depressive-symptoms-in-a-primary-health-care-setting-in-turkey-131485Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı., Keskin, Mehmet Kürşad, Tatar, Banu Taşkıran, Ayar, Koray, Çolpan, Gökhan, Bilgili, Gökhan, Ersoy, Canan, İmamoğlu, Şazi

مصطلحات موضوعية: Obezite, Diyabet, Bel çevresi, Dislipidemi, Diabetes mellitus, BKİ, Dyslipidemia, Obesity, Waist circumference

الوصف: Çalışmamızda diyabetik ve non diyabetik obez kadınlarda dislipidemiyi belirlemede genel obezite göstergesi olan Beden Kitle İndeksinin (BKİ) mi yoksa abdominal obezite göstergesi olan bel çevresinin mi daha etkin olduğunu değerlendirmeyi planladık. BKİ ≥ 25 kg/m² trigliserit düzeyi <400 mg/dl, diyabetik hastalarda A1C değeri ≤ % 7,5 olan, diyabet dışında yandaş hastalığı olmayan, son 3 aydır lipid düşürücü ilaç tedavisi kullanmayan 36 diyabetik, 28 non-diyabetik kadın hastanın verileri retrospektif değerlendirildi. BKİ ve bel çevresiyle lipid parametreleri arasında korelasyon yoktu. Tüm hasta gruplarında kalça çevresiyle trigliserit düzeyi arasında pozitif (r=0,293, p<0,05), yaşla HDL-kolesterol arasında negatif (r=-0,440, p<0,001), LDL arasında pozitif korelasyon (r=0,275, p<0,05) saptandı. BKİ’leri benzer olan diyabetik ve non-diyabetik obez kadınlar karşılaştırıldığında diyabetiklerde abdominal obezitenin; bunun sonucu olabilecek dislipideminin daha belirgin olduğu gösterildi. Çalışmamız bel çevresinin önemini vurgulamakla birlikte genel obezite göstergesi olan BKİ’ninde dislipidemi riskini belirlemede göz önüne alınması gerektiğini ortaya koymaktadır. ; In this study we tried to find out whether BMI, indicator of general obesity, or waist circumference, indicator of abdominal obesity, is more decisive in predicting dislipidemia in diabetic and non-diabetic women. Data of 36 diabetic and 28 non-diabetic women whose BMI ≥ 25 kg/m², triyglyceride ≤ 400 mg /dl, for diabetics A1C ≤ 7,5%, without accompanying illness other than diabetes and using lipid lowering agents for the last 3 months was evaluated retrospectively. There was no correlation between BMI and waist circumference with lipid parameters. There was a positive correlation between hip circumference and tyrglyceride levels.(r=0,293, p<0,05), a negative correlation between age and HDL (r=-0,440, p<0,001), and a positive correlation between age and LDL levels (r=0,275, p<0,05). When we compared ,diabetic and non-diabetic obese women ...

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Uludağ Üniversitesi Tıp Fakültesi Dergisi / Journal of Uludag University Medical Faculty; Keskin, M. K. vd. (2009). ''Diyabetik ve non–diyabetik kadınlarda dislipidemi için beden kitle indeksi ve bel çevresi ne kadar belirleyicidir ?''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 35(2), 69-72.; https://dergipark.org.tr/tr/download/article-file/420834Test; http://hdl.handle.net/11452/18750Test; 69; 72; 35

الإتاحة: http://hdl.handle.net/11452/18750Test
https://dergipark.org.tr/tr/download/article-file/420834Test

المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı., Arı, İlknur, İkiz, İhsaniye, Erem, Türkan, Çimen, Ahmet

مصطلحات موضوعية: Kız öğrenciler, Antropometri, Vücut çevre ölçümleri, Female students, Antropometry, Body circumference measurements

الوصف: Bu çalışma, 22-25 Eylül 1993 tarihleri arasında Adana[Türkiye]'da düzenlenen ll. Ulusal Anatomi Kongresi'nde bildiri olarak sunulmuştur. ; Uludağ Üniversitesi'nde çeşitli fakültelere kayıtlı 300 kız öğrencinin ağırlık, göğüs, bel, kalça ve uyluk çevresi ölçümleri alındı. Çalışmada elde edilen ölçümlerin birbirleriyle olan ilişkileri incelenerek standartlar belirlendi. Çalışma sonunda yaş 19.- 7. 1.59 yıl (ortalama standart sapma), ağırlık 55. 0± 7.17 kg, göğüs çevresi 86.4 : 6.24 cm. bel çevresi 68.- 5.93 cm, kalça çevresi 95/1. 5.72 cm, sağ uyluk çevresi 55.5. 4.42 cm ve sol uyluk çevresi 55.0 /36 cm olarak bulundu. ; Measurements of weight, chest, waist, hip and thigh circumferences have been taken from 300 female students of different faculties in Uludağ University. The standarts have been established by studying the interrelations of the measurements obtained in the study mentioned. As a results of this study, the following measurements have been obtained: age = 19. 7±1. 59 year = (mean± standard deviation), weight 55. 0 ±7.17 kg, chest circumference = 86.4 ± 6. 24 cm, waist circumference = 68.4±5. 93 cm, hip circumference 95.10± 5, 72 cm and right thigh circumference = 55.5± 4.42 cm and left thigh circumference = 55.0 ±4,36 cm.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; Uludağ Üniversitesi Tıp Fakültesi Dergisi; Arı, İ. vd. (1996). ''Uludağ Üniversitesi kız öğrencilerinde bazı antropometrik ölçümlerle vücut çevre ölçümleri standartlarının belirlenmesi''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 23(1-2-3), 65-66.; http://hdl.handle.net/11452/26531Test; 65; 66; 23; 1-2-3

الإتاحة: http://hdl.handle.net/11452/26531Test