المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., orcid:0000-0002-6729-7908, Arı, Ferda, Dere, Egemen, AAH-5068-2021, AAG-7012-2021, 24376085300, 6603627015

مصطلحات موضوعية: Fenarimol, Lactate dehydrogenase, Alkaline phosphatase, Alanine amino transferase, Aspartate amino transferase, Induced infertility, Aromatase-activity, Pesticides, Induction, Mechanism, Enzymes, System, Alpha, Liver, Veterinary sciences, Rattus, Sango, Sprouts (Food), Juices

الوصف: Fenarimol, a 2,4'-dichloro-alpha-(pyrimidin-5-yl) benzhydryl alcohol fungicide and steroid demethylation inhibitor, has been reported to affect the actions of multiple CYP450 isoforms, including key enzymes. The aim of this study was to evaluate the effects of fenarimol on a set of biochemical parameters in rats. Rats were intraperitoneally injected with a 200 mg kg(-1) dose of fenarimol. Blood samples were collected for measurements of serum alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), creatine kinase (CK) activity, and levels of glucose, urea, sodium, and potassium. Serum was analysed at 0, 2, 4, 8, 16, 32, 64 and 72 h following injection. Our results demonstrated a statistically significant increase in ALP; ALT, AST, CK activities and levels of urea from time to time (p<0.05). Our results demonstrate that treatments with fenarimol can alter the activity and levels of selected serum enzymes and biochemical parameters in rats.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; BAP; Acta Veterinaria, Beograd; Arı, F. ve Dere, E. (2010). "Effect of the sterol demethylation-inhibiting fungicide fenarimol on selected biochemical parameters in rats". Acta Veterinaria,Beograd 60(1), 31-38.; https://doi.org/10.2298/AVB1001031ATest; http://hdl.handle.net/11452/24501Test; 000276046300004; 2-s2.0-77950675400; 31; 38; 60

الإتاحة: https://doi.org/10.2298/AVB1001031ATest
http://hdl.handle.net/11452/24501Test

المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., orcid:0000-0002-6729-7908, Arı, Ferda, Dere, Egemen, AAH-5068-2021, AAG-7012-2021, 24376085300, 6603627015

مصطلحات موضوعية: Fenarimol, Lactate dehydrogenase, Alkaline phosphatase, Alanine amino transferase, Aspartate amino transferase, Induced infertility, Aromatase-activity, Pesticides, Induction, Mechanism, Enzymes, System, Alpha, Liver, Veterinary sciences, Rattus, Sango, Sprouts (Food), Juices

الوصف: Fenarimol, a 2,4'-dichloro-alpha-(pyrimidin-5-yl) benzhydryl alcohol fungicide and steroid demethylation inhibitor, has been reported to affect the actions of multiple CYP450 isoforms, including key enzymes. The aim of this study was to evaluate the effects of fenarimol on a set of biochemical parameters in rats. Rats were intraperitoneally injected with a 200 mg kg(-1) dose of fenarimol. Blood samples were collected for measurements of serum alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), creatine kinase (CK) activity, and levels of glucose, urea, sodium, and potassium. Serum was analysed at 0, 2, 4, 8, 16, 32, 64 and 72 h following injection. Our results demonstrated a statistically significant increase in ALP; ALT, AST, CK activities and levels of urea from time to time (p<0.05). Our results demonstrate that treatments with fenarimol can alter the activity and levels of selected serum enzymes and biochemical parameters in rats.

وصف الملف: application/pdf

العلاقة: Makale - Uluslararası Hakemli Dergi; BAP; Acta Veterinaria, Beograd; Arı, F. ve Dere, E. (2010). "Effect of the sterol demethylation-inhibiting fungicide fenarimol on selected biochemical parameters in rats". Acta Veterinaria,Beograd 60(1), 31-38.; https://doi.org/10.2298/AVB1001031ATest; http://hdl.handle.net/11452/24501Test; 000276046300004; 2-s2.0-77950675400; 31; 38; 60

الإتاحة: https://doi.org/10.2298/AVB1001031ATest
http://hdl.handle.net/11452/24501Test

المساهمون: Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı., Topal, Ayşe, Gül, Nihal Yaşar, İlçöl, Yeşim Özarda, Görgül, Osman Sacit, AAL-8873-2021, 56357211200, 55899103700, 57210033454, 6507730974

مصطلحات موضوعية: Veterinary sciences, Canis familiaris, Liver, Necrosis, Alkaline phosphatase, Anesthesia, Anesthetics, inhalation, Animals, Aspartate aminotransferases, Bilirubin, Dogs, Female, Gamma-glutamyltransferase, Halothane, Isoflurane, L-lactate dehydrogenase, Liver function tests, Male, Methyl ethers, Sevoflurane, Halothane Hepatitis, Inhalation Anesthetic Agent, Aspartate aminotransferase, Ether derivative, Gamma glutamyltransferase, Lactate dehydrogenase, Animal, Animal disease, Article

الوصف: The effects of halothane, isoflurane and sevoflurane anaesthesia on hepatic function and hepatocellular damage were investigated in dogs, comparing the activity of hepatic enzymes and bilirubin concentration in serum. An experimental study was designed. Twenty-one clinically normal mongrel dogs were divided into three groups and accordingly anaesthetized with halothane (n=7), isoflurane (n=7) and sevoflurane (n=7). The dogs were 1-4 years old, and weighed between 13.5 and 27 kg (18.4+/-3.9). Xylazine HCI (1-2 mg/kg) i.m. was used as pre-anaesthetic medication. Anaesthesia was induced with propofol 2 mg/kg i.v. The trachea was intubated and anaesthesia maintained with halothane, isoflurane or sevoflurane in oxygen at concentrations of 1.35, 2 and 3%, respectively. Intermittent positive pressure ventilation (tidal volume, 15 ml/kg; respiration rate, 12-14/min) was started immediately after intubation and the anaesthesia lasted for 60 min. Venous blood samples were collected before pre-medication, 24 and 48 h, and 7 and 14 days after anaesthesia. Serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH GGT) activities and bilirubin concentration were measured. Serum AST, ALT and GGT activities increased after anaesthesia, in all groups. In the halothane group, serum AST and ALT activities significantly increased all the time after anaesthesia compared with baseline activities. But in the isoflurane group AST and ALT activities increased only between 2 and 7 days, and in the sevoflurane group 7 days after anaesthesia. GGT activity was increased in the halothane group between 2 and 7 days, and in the isoflurane and sevoflurane groups 7 days after anaesthesia. All dogs recovered from anaesthesia without complications and none developed clinical signs of hepatic damage within 14 days. The results suggest that the use of halothane anaesthesia induces an elevation of serum activities of liver enzymes more ...

العلاقة: Makale - Uluslararası Hakemli Dergi; Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine; Topal, A. vd. (2003). “Hepatic effects of halothane, isoflurane or sevoflurane anaesthesia in dogs”. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine, 50(10), 530-533.; https://doi.org/10.1111/j.1439-0442.2004.00589.xTest; http://hdl.handle.net/11452/22287Test; 000220782900010; 2-s2.0-3042850645; 530; 533; 50; 10

الإتاحة: https://doi.org/10.1111/j.1439-0442.2004.00589.xTest
http://hdl.handle.net/11452/22287Test

المساهمون: Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı., Topal, Ayşe, Gül, Nihal Yaşar, İlçöl, Yeşim Özarda, Görgül, Osman Sacit, AAL-8873-2021, 56357211200, 55899103700, 57210033454, 6507730974

مصطلحات موضوعية: Veterinary sciences, Canis familiaris, Liver, Necrosis, Alkaline phosphatase, Anesthesia, Anesthetics, inhalation, Animals, Aspartate aminotransferases, Bilirubin, Dogs, Female, Gamma-glutamyltransferase, Halothane, Isoflurane, L-lactate dehydrogenase, Liver function tests, Male, Methyl ethers, Sevoflurane, Halothane Hepatitis, Inhalation Anesthetic Agent, Aspartate aminotransferase, Ether derivative, Gamma glutamyltransferase, Lactate dehydrogenase, Animal, Animal disease, Article

الوصف: The effects of halothane, isoflurane and sevoflurane anaesthesia on hepatic function and hepatocellular damage were investigated in dogs, comparing the activity of hepatic enzymes and bilirubin concentration in serum. An experimental study was designed. Twenty-one clinically normal mongrel dogs were divided into three groups and accordingly anaesthetized with halothane (n=7), isoflurane (n=7) and sevoflurane (n=7). The dogs were 1-4 years old, and weighed between 13.5 and 27 kg (18.4+/-3.9). Xylazine HCI (1-2 mg/kg) i.m. was used as pre-anaesthetic medication. Anaesthesia was induced with propofol 2 mg/kg i.v. The trachea was intubated and anaesthesia maintained with halothane, isoflurane or sevoflurane in oxygen at concentrations of 1.35, 2 and 3%, respectively. Intermittent positive pressure ventilation (tidal volume, 15 ml/kg; respiration rate, 12-14/min) was started immediately after intubation and the anaesthesia lasted for 60 min. Venous blood samples were collected before pre-medication, 24 and 48 h, and 7 and 14 days after anaesthesia. Serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH GGT) activities and bilirubin concentration were measured. Serum AST, ALT and GGT activities increased after anaesthesia, in all groups. In the halothane group, serum AST and ALT activities significantly increased all the time after anaesthesia compared with baseline activities. But in the isoflurane group AST and ALT activities increased only between 2 and 7 days, and in the sevoflurane group 7 days after anaesthesia. GGT activity was increased in the halothane group between 2 and 7 days, and in the isoflurane and sevoflurane groups 7 days after anaesthesia. All dogs recovered from anaesthesia without complications and none developed clinical signs of hepatic damage within 14 days. The results suggest that the use of halothane anaesthesia induces an elevation of serum activities of liver enzymes more ...

العلاقة: Makale - Uluslararası Hakemli Dergi; Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine; Topal, A. vd. (2003). “Hepatic effects of halothane, isoflurane or sevoflurane anaesthesia in dogs”. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine, 50(10), 530-533.; https://doi.org/10.1111/j.1439-0442.2004.00589.xTest; http://hdl.handle.net/11452/22287Test; 000220782900010; 2-s2.0-3042850645; 530; 533; 50; 10

الإتاحة: https://doi.org/10.1111/j.1439-0442.2004.00589.xTest
http://hdl.handle.net/11452/22287Test

المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı., orcid:0000-0002-6729-7908, Dere, Egemen, Arı, Ferda, AAG-7012-2021, AAH-5068-2021, 6603627015, 24376085300

مصطلحات موضوعية: Alanine amino transferase, Alkaline phosphatase, Aspartate amino transferase, Benzene, Lactate dehydrogenase, Microsomal membrane, Hl-60 cells, Exposure, Tissues, Phosphorothionate, Metabolites, Blood, Acid, Environmental sciences & ecology, Rattus, Rattus norvegicus, Amination, Amines, Body fluids, Rats, Aspartate, Carcinogenic agents, Control groups, Intraperitoneally, Enzymes, Measurement method, Phosphatase, Physiology, Rodent, Serum

الوصف: Rats (Rattus norvegicus) were intraperitoneally injected with a 100 mg kg (-aEuro parts per thousand 1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST) activities in serum of rats were investigated at 2, 4, 8, 16, 32, and 64 h following injection. Serum physiological was administered to control group. Activities were measured using autoanalyzer. Benzene caused significant activations in LDH, ALP, and AST activities in the serum at some test hours (p < 0.05). When compared with the control groups, although an increase occurred in ALT activity, it was seem that this increase wasn't significant (p > 0.05).

العلاقة: Makale - Uluslararası Hakemli Dergi; Environmental Monitoring and Assessment; Dere, E. ve Arı, F. (2009). "Effect of benzene on liver functions in rats (Rattus norvegicus)". Environmental Monitoring and Assessment, 154(1-4), 23-27.; https://doi.org/10.1007/s10661-008-0374-7Test; https://link.springer.com/article/10.1007%2Fs10661-008-0374-7Test; http://hdl.handle.net/11452/23172Test; 000267824400003; 2-s2.0-67650607731; 23; 27; 154; 1-4

الإتاحة: https://doi.org/10.1007/s10661-008-0374-7Test
http://hdl.handle.net/11452/23172Test

المساهمون: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı., orcid:0000-0002-6729-7908, Dere, Egemen, Arı, Ferda, AAG-7012-2021, AAH-5068-2021, 6603627015, 24376085300

مصطلحات موضوعية: Alanine amino transferase, Alkaline phosphatase, Aspartate amino transferase, Benzene, Lactate dehydrogenase, Microsomal membrane, Hl-60 cells, Exposure, Tissues, Phosphorothionate, Metabolites, Blood, Acid, Environmental sciences & ecology, Rattus, Rattus norvegicus, Amination, Amines, Body fluids, Rats, Aspartate, Carcinogenic agents, Control groups, Intraperitoneally, Enzymes, Measurement method, Phosphatase, Physiology, Rodent, Serum

الوصف: Rats (Rattus norvegicus) were intraperitoneally injected with a 100 mg kg (-aEuro parts per thousand 1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST) activities in serum of rats were investigated at 2, 4, 8, 16, 32, and 64 h following injection. Serum physiological was administered to control group. Activities were measured using autoanalyzer. Benzene caused significant activations in LDH, ALP, and AST activities in the serum at some test hours (p < 0.05). When compared with the control groups, although an increase occurred in ALT activity, it was seem that this increase wasn't significant (p > 0.05).

العلاقة: Makale - Uluslararası Hakemli Dergi; Environmental Monitoring and Assessment; Dere, E. ve Arı, F. (2009). "Effect of benzene on liver functions in rats (Rattus norvegicus)". Environmental Monitoring and Assessment, 154(1-4), 23-27.; https://doi.org/10.1007/s10661-008-0374-7Test; https://link.springer.com/article/10.1007%2Fs10661-008-0374-7Test; http://hdl.handle.net/11452/23172Test; 000267824400003; 2-s2.0-67650607731; 23; 27; 154; 1-4

الإتاحة: https://doi.org/10.1007/s10661-008-0374-7Test
http://hdl.handle.net/11452/23172Test