دورية أكاديمية
أعرض في EDS

Role of exercise in vascular function and inflammatory profile in age-related obesity

التفاصيل البيبلوغرافية
العنوان: Role of exercise in vascular function and inflammatory profile in age-related obesity
المؤلفون: Pedrinolla, Anna, Venturelli, Massimo, Moschetta, Federica, Zardini, Monica, Rudi, Doriana, Bacchi, Elisabetta, Schena, Federico, Moghetti, Paolo, Lanza, Massimo
المساهمون: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Kırmızı, Emine, 57205595616
بيانات النشر: Hindawi
سنة النشر: 2018
المجموعة: Açık Erişim@BUU (Bursa Uludağ Üniversitesi)
مصطلحات موضوعية: Immunology, Physical-activity, Skeletal-muscle, Adipose-tissue, Older-adults, Men, Impairment, Capacity, Diet, Adiposity, Aged, Aging, Angioplasty, balloon, Blood pressure determination, C-reactive protein, Cytokines, Exercise, Female, Humans, Inflammation, Inflammation mediators, Male, Obesity, Vascular diseases, C Reactive Protein, Waist Circumference, Body Mass, Antacid agent, C reactive protei
الوصف: In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile. Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases. Nonetheless, its long-term effect on vascular function and inflammation in age-related obesity is still unclear. The aim of this study was to investigate the effect of regular, supervised exercise on inflammatory profile and vascular function in age-related obesity. We also hypothesized that vascular function and inflammatory profile would have been correlated in overweight and obese individuals. Thirty normal weight (NW; 70 +/- 5 years, 23.9 +/- 2.6 BMI) and forty overweight and obese elderly (OW & OB; 69 +/- 5 years, 30.1 +/- 2.3 BMI) regularly taking part in a structured, supervised exercise program were enrolled in the study and evaluated for vascular function (flow-mediated dilation; FMD) and inflammatory profile (plasma CRP, IL-1 beta, IL-1ra, IL-6, IL-8, IL-10, TNF-alpha, and MCP-1). Although no differences between groups were found concerning performance and the weekly amount of physical activity, the OW&OB group compared with the NW group demonstrated higher systolic and diastolic blood pressure (10%, p = 0.001; +9%, p = 0.005, respectively); lower FMD% (-36%, p < 0.001) and FMD/shear rate (-40%, p = 0.001); and higher levels of CRP (+33%, p = 0.005), IL-6 (+36%, p = 0.048), MCP-1 (+17%, p = 0.004), and TNF-alpha (+16%, p = 0.031). No correlations between vascular function and inflammation were found in OW&OB or NW. Although exercising regularly, overweight and obese elderly exhibited poorer vascular function and higher proinflammatory markers compared with the leaner group. These results support the idea that exercise alone cannot counteract the negative effect of adiposity on vascular function and inflammatory profile in elderly individuals and these two processes are not necessarily ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 2314-8861
2314-7156
العلاقة: Makale - Uluslararası Hakemli Dergi; Journal of Immunology Research; Yurt dışı; Sanayi; Pedrinolla, A. vd. (2018). ''Role of exercise in vascular function and inflammatory profile in age-related obesity''. Journal of Immunology Research, 2018.; https://doi.org/10.1155/2018/7134235Test; https://www.hindawi.com/journals/jir/2018/7134235Test/; http://hdl.handle.net/11452/34683Test; 000449834100001; 2-s2.0-85060713276; 2018
DOI: 10.1155/2018/7134235
الإتاحة: https://doi.org/10.1155/2018/7134235Test
http://hdl.handle.net/11452/34683Test
https://www.hindawi.com/journals/jir/2018/7134235Test/
حقوق: info:eu-repo/semantics/openAccess ; Atıf Gayri Ticari Türetilemez 4.0 Uluslararası ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/
رقم الانضمام: edsbas.1E99A857
قاعدة البيانات: BASE
الوصف
تدمد:23148861
23147156
DOI:10.1155/2018/7134235