دورية أكاديمية
Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies
| العنوان: | Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies |
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| المؤلفون: | Mayer, Claus-Dieter, de La Giclais, Soizick Magon, Alsehly, Fozan, Hoppler, Stefan |
| المساهمون: | University of Aberdeen.Rowett Institute, University of Aberdeen.Medical Sciences - Cardiovascular Group, University of Aberdeen.Medical Sciences |
| سنة النشر: | 2020 |
| المجموعة: | Aberdeen University Research Archive (AURA) |
| مصطلحات موضوعية: | SDG 3 - Good Health and Well-being, Wnt, colorectal cancer, TCF, LEF, transcriptome, HUMAN COLON, TARGET, STEM-CELLS, PROTEIN, CYCLIN D1, BETA-CATENIN, NEGATIVE REGULATOR, OVEREXPRESSION, GENE, SIGNALING PATHWAY, QH426 Genetics, R Medicine (General), Genetics(clinical), Genetics, Biotechnology and Biological Sciences Research Council (BBSRC), BB/M001695/1, BB/S018190/1, Rural and Environmental Science and Analytical Services (RESAS), Supplementary Data, QH426, R1 |
| الوصف: | Funding: CM acknowledges funding from the Scottish Government: Rural & Environment Science & Analytical Services. (RESAS). SH is a Royal Society/Leverhulme Trust Senior Research Fellow (SRF\R1\191017) and acknowledges research funding from the Biotechnology and Biological Sciences Research Council (BB/S018190/1, BB/M001695/1). Author Contributions: C.-D.M. and S.H. had conceived and supervised this project; C.-D.M. curated the data and carried out some analysis; S.M.L.G., carried out most of the analysis; F.A. wrote an original draft together with Stefan Hoppler. All authors have read and agreed to the published version of the manuscript. Supplementary Materials: The following are available online at www.mdpi.com/2073-4425/11/5/538/s1: Figure S1: Principal Component Analysis of selected studies, Figure S2: Principal Component Analysis of de-selected study, Table S1: Transcriptomics Data (Correlation Coefficients) Table S1A: Transcript correlation between eight selected genes (TCF7, LEF1, TCF7L1, TCF7L2, AXIN2, DKK1, FZD7, LGR5); Table S1B: The TCF7-correlated transcriptome; Table S1C: The LEF1correlated transcriptome; Table S1D: The TCF7L1-correlated transcriptome; Table S1E: The TCF7L2-correlated transcriptome; Table S1F: The AXIN2-correlated transcriptome; Table S1G: The DKK1-correlated transcriptome; Table S1H: The FZD7-correlated transcriptome; Table S1I: The LGR5-correlated transcriptome; Table S1J: Differences in LEF/TCF-correlated transcriptomes; Table S1K: Differences between AXIN2- and LEF/TCF-correlated transcriptomes, Table S2: Correlated Transcriptome in normal and tumor tissue, Table S3: Comparison of LEF/TCF-correlated transcriptomes, Table S4: Differences between AXIN1- and LEF/TCF-correlated transcriptomes. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4425 |
| العلاقة: | Genes; 162667852; 19f4413b-2da6-469a-86b5-41bca13df95f; 85084626943; 000542276700041; Mayer , C-D , de La Giclais , S M , Alsehly , F & Hoppler , S 2020 , ' Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies ' , Genes , vol. 11 , no. 5 , 538 . https://doi.org/10.3390/genes11050538Test; https://hdl.handle.net/2164/14315Test; http://www.scopus.com/inward/record.url?scp=85084626943&partnerID=8YFLogxKTest; http://www.mdpi.com/2073-4425/11/5/538/s1Test |
| DOI: | 10.3390/genes11050538 |
| الإتاحة: | https://doi.org/10.3390/genes11050538Test https://hdl.handle.net/2164/14315Test http://www.scopus.com/inward/record.url?scp=85084626943&partnerID=8YFLogxKTest http://www.mdpi.com/2073-4425/11/5/538/s1Test |
| رقم الانضمام: | edsbas.D419521 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734425 |
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| DOI: | 10.3390/genes11050538 |