دورية أكاديمية
Moving in Semantic Space in Prodromal and Very Early Alzheimer's Disease
| العنوان: | Moving in Semantic Space in Prodromal and Very Early Alzheimer's Disease |
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| المؤلفون: | Saranpää, Aino M., Kivisaari, Sasa L., Salmelin, Riitta, Krumm, Sabine |
| المساهمون: | Department of Neuroscience and Biomedical Engineering, University of Basel, Aalto-yliopisto, Aalto University |
| بيانات النشر: | FRONTIERS MEDIA SA |
| سنة النشر: | 2022 |
| المجموعة: | Aalto University Publication Archive (Aaltodoc) / Aalto-yliopiston julkaisuarkistoa |
| مصطلحات موضوعية: | Alzheimer's disease, Mild Cognitive Impairment, semantic fluency, semantic memory, t-SNE, verbal fluency |
| الوصف: | Funding Information: We thank Kirsten I. Taylor, Ph.D., who was the principal investigator of the Ambizione study and who let us use the data set for our analyses. The content of the present manuscript has originally appeared online in a master's thesis (Saranp??, 2020). We thank Mr. Jari Lipsanen from Helsinki University for his invaluable role as an advisory for the master's thesis and for technical aid with the analyses performed. Publisher Copyright: Copyright © 2022 Saranpää, Kivisaari, Salmelin and Krumm. ; The semantic fluency task is a widely used clinical tool in the diagnostic process of Alzheimer's disease. The task requires efficient mapping of the semantic space to produce as many items as possible within a semantic category. We examined whether healthy volunteers (n = 42) and patients with early Alzheimer's disease (24 diagnosed with amnestic Mild Cognitive Impairment and 18 with early Alzheimer's dementia) take advantage of and travel in the semantic space differently. With focus on the animal fluency task, we sought to emulate the detailed structure of the multidimensional semantic space by utilizing word2vec-method from the natural language processing domain. To render the resulting multidimensional semantic space visually comprehensible, we applied a dimensionality reduction algorithm (t-SNE), which enabled a straightforward division of the semantic space into sub-categories. Moving in semantic space was quantified with the number of items created, sub-categories visited, and switches and returns to these sub-categories. Multinomial logistic regression models were used to predict the diagnostic group with these independent variables. We found that returning to a sub-category provided additional information, besides the number of words produced in the task, to differentiate patients with Alzheimer's dementia from both amnestic Mild Cognitive Impairment patients and healthy controls. The results suggest that the frequency of returning to a sub-category may serve as an additional aid for ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-1078 |
| العلاقة: | Frontiers in Psychology; Volume 13; Saranpää , A M , Kivisaari , S L , Salmelin , R & Krumm , S 2022 , ' Moving in Semantic Space in Prodromal and Very Early Alzheimer's Disease : An Item-Level Characterization of the Semantic Fluency Task ' , Frontiers in Psychology , vol. 13 , 777656 , pp. 1-12 . https://doi.org/10.3389/fpsyg.2022.777656Test; PURE UUID: 0302693f-e0d2-4797-a64c-0e5c73edbe06; PURE ITEMURL: https://research.aalto.fi/en/publications/0302693f-e0d2-4797-a64c-0e5c73edbe06Test; PURE LINK: http://www.scopus.com/inward/record.url?scp=85125871824&partnerID=8YFLogxKTest; PURE FILEURL: https://research.aalto.fi/files/81001155/Moving_in_Semantic_Space_in_Prodromal_and_Very_Early_Alzheimer_s_Disease.pdfTest; https://aaltodoc.aalto.fi/handle/123456789/113728Test; URN:NBN:fi:aalto-202203282605 |
| DOI: | 10.3389/fpsyg.2022.777656 |
| الإتاحة: | https://doi.org/10.3389/fpsyg.2022.777656Test https://aaltodoc.aalto.fi/handle/123456789/113728Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.6CD82AE5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16641078 |
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| DOI: | 10.3389/fpsyg.2022.777656 |