دورية أكاديمية
Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System
| العنوان: | Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System |
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| المؤلفون: | Jha, Niraj Kumar, Ojha, Shreesh, Jha, Saurabh Kumar, Dureja, Harish, Singh, Sachin Kumar, Shukla, Shakti D., Chellappan, Dinesh Kumar, Gupta, Gaurav, Bhardwaj, Shanu, Kumar, Neeraj, Jeyaraman, Madhan, Jain, Rashmi, Muthu, Sathish, Kar, Rohan, Kumar, Dhruv, Goswami, Vineet Kumar, Ruokolainen, Janne, Kesari, Kavindra Kumar, Singh, Sandeep Kumar, Dua, Kamal |
| المساهمون: | Sharda University, United Arab Emirates University, Maharshi Dayanand University, Lovely Professional University, University of Newcastle, International Medical University, Suresh Gyan Vihar University, CCS University, University of Delhi, Indian Orthopaedic Research Group, Indian Institute of Management, Amity University, GD Goenka University, Department of Applied Physics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Aalto-yliopisto, Aalto University |
| بيانات النشر: | Humana Press |
| سنة النشر: | 2021 |
| المجموعة: | Aalto University Publication Archive (Aaltodoc) / Aalto-yliopiston julkaisuarkistoa |
| مصطلحات موضوعية: | ACE2, Cerebrovascular disease, Coronavirus (CoV), COVID-19, Guillain-Barré syndrome (GBS), Multiple sclerosis, Nervous system, Neuropathogenesis, SARS-CoV-2 |
| الوصف: | The coronavirus disease 2019 (COVID-19) pandemic is an issue of global significance that has taken the lives of many across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for its pathogenesis. The pulmonary manifestations of COVID-19 have been well described in the literature. Initially, it was thought to be limited to the respiratory system; however, we now recognize that COVID-19 also affects several other organs, including the nervous system. Two similar human coronaviruses (CoV) that cause severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) are also known to cause disease in the nervous system. The neurological manifestations of SARS-CoV-2 infection are growing rapidly, as evidenced by several reports. There are several mechanisms responsible for such manifestations in the nervous system. For instance, post-infectious immune-mediated processes, direct virus infection of the central nervous system (CNS), and virus-induced hyperinflammatory and hypercoagulable states are commonly involved. Guillain-Barré syndrome (GBS) and its variants, dysfunction of taste and smell, and muscle injury are numerous examples of COVID-19 PNS (peripheral nervous system) disease. Likewise, hemorrhagic and ischemic stroke, encephalitis, meningitis, encephalopathy acute disseminated encephalomyelitis, endothelialitis, and venous sinus thrombosis are some instances of COVID-19 CNS disease. Due to multifactorial and complicated pathogenic mechanisms, COVID-19 poses a large-scale threat to the whole nervous system. A complete understanding of SARS-CoV-2 neurological impairments is still lacking, but our knowledge base is rapidly expanding. Therefore, we anticipate that this comprehensive review will provide valuable insights and facilitate the work of neuroscientists in unfolding different neurological dimensions of COVID-19 and other CoV associated abnormalities. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0895-8696 20211104 |
| العلاقة: | JOURNAL OF MOLECULAR NEUROSCIENCE; Jha , N K , Ojha , S , Jha , S K , Dureja , H , Singh , S K , Shukla , S D , Chellappan , D K , Gupta , G , Bhardwaj , S , Kumar , N , Jeyaraman , M , Jain , R , Muthu , S , Kar , R , Kumar , D , Goswami , V K , Ruokolainen , J , Kesari , K K , Singh , S K & Dua , K 2021 , ' Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System : A Review on Neurological Impairments and Manifestations ' , JOURNAL OF MOLECULAR NEUROSCIENCE , vol. 71 , no. 11 , pp. 2192-2209 . https://doi.org/10.1007/s12031-020-01767-6Test; PURE UUID: 2c26eb9a-d317-4453-ad30-bce97fb336fd; PURE ITEMURL: https://research.aalto.fi/en/publications/2c26eb9a-d317-4453-ad30-bce97fb336fdTest; PURE LINK: http://www.scopus.com/inward/record.url?scp=85099550796&partnerID=8YFLogxKTest; PURE LINK: http://hdl.handle.net/10453/145572Test; https://aaltodoc.aalto.fi/handle/123456789/110800Test; URN:NBN:fi:aalto-202111049973 |
| DOI: | 10.1007/s12031-020-01767-6 |
| الإتاحة: | https://doi.org/10.1007/s12031-020-01767-6Test https://aaltodoc.aalto.fi/handle/123456789/110800Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.49DC2886 |
| قاعدة البيانات: | BASE |
| تدمد: | 08958696 20211104 |
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| DOI: | 10.1007/s12031-020-01767-6 |