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Free Insulin-like Growth Factor (IGF)-I in Children with PWS

التفاصيل البيبلوغرافية
العنوان: Free Insulin-like Growth Factor (IGF)-I in Children with PWS
المؤلفون: Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
المصدر: Journal of Clinical Medicine, Vol 11, Iss 5, p 1280 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
مصطلحات موضوعية: free insulin-like growth factor I, immunoreactive insulin-like growth factor I, Prader–Willi syndrome, growth hormone, Medicine
الوصف: In children with Prader–Willi syndrome (PWS), the standard growth hormone (GH) dose often results in high immunoreactive IGF-I levels. These high immunoreactive IGF-I levels lead to concern because their long-term effects are unknown. As a result, clinicians have to lower the GH dose, which worsens body composition and quality of life. As clinical features do not seem to correspond to immunoreactive IGF-I values, it is questionable whether immunoreactive IGF-I is a suitable marker for GH dosing, or whether another parameter better reflects IGF-I bioavailability and bioactivity. We, therefore, investigate serum immunoreactive IGF-I, free IGF-I and IGFBP-3 levels in 70 GH-treated children with PWS. Our study showed that, although immunoreactive IGF-I levels were high (>2 SDS) in the vast majority of prepubertal and pubertal children, free IGF-I SDS levels were 2 SDS in GH-treated children with PWS.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 11051280
2077-0383
العلاقة: https://www.mdpi.com/2077-0383/11/5/1280Test; https://doaj.org/toc/2077-0383Test
DOI: 10.3390/jcm11051280
الوصول الحر: https://doaj.org/article/42459a47de4f40fe9d51a62f795a33e9Test
رقم الانضمام: edsdoj.42459a47de4f40fe9d51a62f795a33e9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11051280
20770383
DOI:10.3390/jcm11051280