دورية أكاديمية
CCR9 Antagonists in the Treatment of Ulcerative Colitis
| العنوان: | CCR9 Antagonists in the Treatment of Ulcerative Colitis |
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| المؤلفون: | Pirow Bekker, Karen Ebsworth, Matthew J. Walters, Robert D. Berahovich, Linda S. Ertl, Trevor T. Charvat, Sreenivas Punna, Jay P. Powers, James J. Campbell, Timothy J. Sullivan, Juan C. Jaen, Thomas J. Schall |
| المصدر: | Mediators of Inflammation, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine and the development of small-intestinal inflammation, the role of this chemokine-receptor pair in colonic inflammation is not clear. Toward this end, we compared colonic CCL25 protein levels in healthy individuals to those in patients with ulcerative colitis. In addition, we determined the effect of CCR9 pharmacological inhibition in the mdr1a−/− mouse model of ulcerative colitis. Colon samples from patients with ulcerative colitis had significantly higher levels of CCL25 protein compared to healthy controls, a finding mirrored in the mdr1a−/− mice. In the mdr1a−/− mice, CCR9 antagonists significantly decreased the extent of wasting and colonic remodeling and reduced the levels of inflammatory cytokines in the colon. These findings indicate that the CCR9:CCL25 pair plays a causative role in ulcerative colitis and suggest that CCR9 antagonists will provide a therapeutic benefit in patients with colonic inflammation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 |
| العلاقة: | https://doaj.org/toc/0962-9351Test; https://doaj.org/toc/1466-1861Test |
| DOI: | 10.1155/2015/628340 |
| الوصول الحر: | https://doaj.org/article/c638bdfdaf0d453fa06dafe9158d5f09Test |
| رقم الانضمام: | edsdoj.638bdfdaf0d453fa06dafe9158d5f09 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1155/2015/628340 |