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Peptide nanogels as a scaffold for fabricating dermal grafts and 3D vascularized skin models

التفاصيل البيبلوغرافية
العنوان: Peptide nanogels as a scaffold for fabricating dermal grafts and 3D vascularized skin models
المؤلفون: Wafaa T Arab, Hepi H Susapto, Dana Alhattab, Charlotte A E Hauser
المصدر: Journal of Tissue Engineering, Vol 13 (2022)
بيانات النشر: SAGE Publishing, 2022.
سنة النشر: 2022
المجموعة: LCC:Biochemistry
مصطلحات موضوعية: Biochemistry, QD415-436
الوصف: Millions of people worldwide suffer from skin injuries, which create significant problems in their lives and are costly to cure. Tissue engineering is a promising approach that aims to fabricate functional organs using biocompatible scaffolds. We designed ultrashort tetrameric peptides with promising properties required for skin tissue engineering. Our work aimed to test the efficacy of these scaffolds for the fabrication of dermal grafts and 3D vascularized skin tissue models. We found that the direct contact of keratinocytes and fibroblasts enhanced the proliferation of the keratinocytes. Moreover, the expression levels of TGF-β1, b-FGF, IL-6, and IL-1α is correlated with the growth of the fibroblasts and keratinocytes in the co-culture. Furthermore, we successfully produced a 3D vascularized skin co-culture model using these peptide scaffolds. We believe that the described results represent an advancement in the fabrication of skin tissue equivalent, thereby providing the opportunity to rebuild missing, failing, or damaged parts. Graphical abstract
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-7314
20417314
العلاقة: https://doaj.org/toc/2041-7314Test
DOI: 10.1177/20417314221111868
الوصول الحر: https://doaj.org/article/9d39c5ed7e644e028ba2bd759ba6c19eTest
رقم الانضمام: edsdoj.9d39c5ed7e644e028ba2bd759ba6c19e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20417314
DOI:10.1177/20417314221111868