دورية أكاديمية
SIRT1 (rs3740051) role in pituitary adenoma development
| العنوان: | SIRT1 (rs3740051) role in pituitary adenoma development |
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| المؤلفون: | Rasa Liutkeviciene, Alvita Vilkeviciute, Greta Morkunaite, Brigita Glebauskiene, Loresa Kriauciuniene |
| المصدر: | BMC Medical Genetics, Vol 20, Iss 1, Pp 1-7 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Pituitary adenoma, SIRT1 (rs4746720, rs3740051) gene polymorphisms, Invasiveness, Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Abstract Background Our purpose was to determine if SIRT1 (rs4746720, rs3740051) genotypes have an influence on the development of pituitary adenoma (PA). Methods The study group included 142 patients with pituitary adenoma (PA) and the control group consisted of 826 healthy people. The genotyping of SIRT1 (rs4746720, rs3740051) was carried out using the real-time polymerase chain reaction method. Results Statistically significant results were obtained in the analysis of SIRT1 rs3740051. Significant differences in genotype (G/G, G/A, A/A) distribution were obtained comparing patients with PA without recurrence and PA with recurrence (0, 17.9, 82.1% vs. 6.7, 6.7, 86.7%, respectively, p = 0.022). Also, statistically significant differences were observed when comparing the genotype (G/G, G/A, A/A) distribution in the non-invasive PA group and the invasive PA group (3.4, 25.9, 70.7% vs. 0, 8.3, 91.7%, respectively, p = 0.003), and allele G was less frequently observed in invasive PA, than in non-invasive PA (4.2% vs. 16.4%, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2350 |
| العلاقة: | http://link.springer.com/article/10.1186/s12881-019-0892-xTest; https://doaj.org/toc/1471-2350Test |
| DOI: | 10.1186/s12881-019-0892-x |
| الوصول الحر: | https://doaj.org/article/66072ec7b4d64d868bc6a42b84031873Test |
| رقم الانضمام: | edsdoj.66072ec7b4d64d868bc6a42b84031873 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14712350 |
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| DOI: | 10.1186/s12881-019-0892-x |