التفاصيل البيبلوغرافية
| العنوان: |
Increase in autoantibodies against Fas (CD95) during carcinogenesis in the human colon: a hope for the immunoprevention of cancer? |
| المؤلفون: |
Reipert, B.M., Tanneberger, S., Pannetta, A., Bedosti, M., Poell, M., Zimmermann, K., Stellamor, M.T. |
| المصدر: |
Cancer Immunology, Immunotherapy; Oct2005, Vol. 54 Issue 10, p1038-1042, 5p |
| مصطلحات موضوعية: |
COLON cancer, IMMUNE system, IMMUNOLOGY, CARCINOGENESIS, AUTOANTIBODIES, CANCER |
| مستخلص: |
A thorough understanding of the naturally occurring events in the immune system in response to carcinogenesis will facilitate the development of strategies for the immunoprevention of cancer. The adenoma-carcinoma sequence in the human colon is a well-established clinical example of multi-step carcinogenesis and can be used for immunological studies. Based on previous observations that both apoptosis and the expression of Fas (Apo-1, CD95) are altered during carcinogenesis in the human colon, we asked the question whether serum titers of autoantibodies against Fas show any modification during the adenoma-carcinoma sequence. Healthy controls (38), patients with colorectal adenomas (38) and patients with colorectal adenocarcinomas (21) were investigated. Anti-Fas antibody titers were found to be significantly higher in patients with colorectal adenomas than in healthy controls and higher still in patients with colorectal adenocarcinomas. This increase in anti-Fas autoantibody titers during carcinogenesis might reflect the activation of natural defense mechanisms by the immune system. [ABSTRACT FROM AUTHOR] |
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