دورية أكاديمية
Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma
| العنوان: | Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma |
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| المؤلفون: | Pasquale Angrisani, Roberto Cuomo, Domenico Memoli, Giuseppina Liguori, Carlo Baldi, Alessia Caleo, Antonio D'Antonio, Basilio Angrisani |
| المصدر: | Rare Tumors, Vol 3, Iss 1, Pp e10-e10 (2011) |
| بيانات النشر: | SAGE Publishing, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | pleomorphic liposarcoma, FISH analysis, epithelioid variant, immunohistochemistry, differential diagnosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | We report a case of epithelioid variant of pleomorphic liposarcoma (EPL) found in the the infrapatellar fat pad of Hoffa of a 31-year old male. Histologically, the predominant population was formed by epithelioid cells with eosinophilic or clear cytoplasm admixed with rare pleomorphic lipoblasts. The immunohistochemical panel was not helpful in the diagnosis. FISH analysis using the locus-specific indicator CHOP (12q13) dual color break apart was applied to representative formalin-fixed, paraffin-embedded tissue sections. The result of FISH indicated a rearranged CHOP (DDIT3) gene and confirmed the diagnosis of EPL. The EPL should be differentiated from a metastatic carcinoma or other type of sarcoma. In these cases a clinicopathological correlation and an exhaustive sampling of the specimen for demonstration of lipogenic areas or pleomorphic lipoblasts is always necessary. FISH with demonstration of CHOP gene rearrangement is useful in providing specific ancillary information for the difficult differential diagnosis of this case. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2036-3605 2036-3613 |
| العلاقة: | http://www.pagepress.org/journals/index.php/rt/article/view/2249Test; https://doaj.org/toc/2036-3605Test; https://doaj.org/toc/2036-3613Test |
| DOI: | 10.4081/rt.2011.e10 |
| الوصول الحر: | https://doaj.org/article/1a00e97fc780451ba26d994d7caef6f2Test |
| رقم الانضمام: | edsdoj.1a00e97fc780451ba26d994d7caef6f2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20363605 20363613 |
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| DOI: | 10.4081/rt.2011.e10 |