التفاصيل البيبلوغرافية
| العنوان: |
A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts I cell development. |
| المؤلفون: |
Gosling, Katharine M., Makaroff, Lydia E., Theodoratos, Angelo, Yong-Hee Kim, Whittie, Belinda, Lixin Rui, Hua Wu, Hong, Nancy A., Gavin C. Kennedy, Julie-Anne Fritz, Adele L. Yates, Christopher C. Goodnow, Fahrer, Aude M. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 7/24/2007, Vol. 104 Issue 30, p12445-12450, 6p, 1 Diagram, 4 Graphs |
| مصطلحات موضوعية: |
GENETIC mutation, T cells, LYMPHOCYTES, CELL differentiation, CELL nuclei, EXONS (Genetics) |
| مستخلص: |
Condensins are ubiquitously expressed multiprotein complexes that are important for chromosome condensation and epigenetic regulation of gene transcription, but whose specific roles in vertebrates are poorly understood. We describe a mouse strain, nessy, isolated during an ethylnitrosourea screen for recessive immunological mutations. The nessy mouse has a defect in T lymphocyte development that decreases circulating T cell numbers, increases their expression of the activation/memory marker CD44. and dramatically decreases the numbers of CD4+ CD8+ thymocytes and their immediate DN4 precursors. A missense mutation in an unusual alternatively spliced first exon of the kleisin p gene, a member of the condensin II complex, was shown to be responsible and act in a T cell-autonomous manner. Despite the ubiquitous expression and role of condensins. kleisin pnes/nes mice were viable, fertile, and showed no defects even in the parallel pathway of B cell lymphocyte differentiation. These data define a unique lineage-specific requirement for kleisin β in mammalian T cell differentiation. [ABSTRACT FROM AUTHOR] |
|
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder