دورية أكاديمية
Impact of a Multi-Strain Probiotic on Healthcare-Associated Bloodstream Infection Incidence and Severity in Preterm Neonates
| العنوان: | Impact of a Multi-Strain Probiotic on Healthcare-Associated Bloodstream Infection Incidence and Severity in Preterm Neonates |
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| المؤلفون: | Marwyn Sowden, Mirjam Maria van Weissenbruch, Andre Nyandwe Hamama Bulabula, Angela Dramowski, Carl Lombard, Evette van Niekerk |
| المصدر: | Journal of Pediatric Research, Vol 9, Iss 4, Pp 345-353 (2022) |
| بيانات النشر: | Galenos Yayinevi, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Pediatrics |
| مصطلحات موضوعية: | healthcare-associated bloodstream infection, neonate, probiotic, Medicine, Pediatrics, RJ1-570 |
| الوصف: | Aim:Hospital acquired bloodstream infection (HA-BSI) is a major contributor to morbidity and mortality in preterm, very low birthweight infants, especially in low-to-middle- income countries.Materials and Methods:We conducted a double-blind, placebo-controlled, randomized clinical trial to investigate the effect of a multi-strain probiotic formulation (LabinicTM) on the incidence and severity of HA-BSI in preterm neonates.Results:Two hundred neonates (100 per arm) were included in this trial. Fifteen neonates developed HA-BSI events (2 in the probiotic arm and 13 in the placebo arm). The median day of life at HA-BSI onset for the probiotic group was 10.5±3.5, and for the placebo group, it was 11.2±6.4. The incidence of HA-BSI in neonates receiving the probiotic was significantly lower compared to those receiving the placebo [0.93 versus 5.99 HA-BSI events/1,000 neonate-days; incidence rate ratio (IRR) of 0.156 [95% confidence interval (CI): 0.017 to 0.691], p=0.0046]. Calculating the incidence rate of the combined outcome (sepsis/death) was also lower in the probiotic group versus the placebo group [2.34 versus 6.45 events/1,000 neonate days; IRR 0.33 (95% CI: 0.11 to 0.97), p=0.043].Conclusion:The use of a multi-strain probiotic significantly reduced HA-BSI incidence in this cohort of preterm neonates. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 2147-9445 2587-2478 |
| العلاقة: | http://jpedres.org/archives/archive-detail/article-preview/mpact-of-a-multi-strain-probiotic-on-healthcare-as/57511Test; https://doaj.org/toc/2147-9445Test; https://doaj.org/toc/2587-2478Test |
| DOI: | 10.4274/jpr.galenos.2022.56667 |
| الوصول الحر: | https://doaj.org/article/ffa680aeab224a5b86c23cf249efddbcTest |
| رقم الانضمام: | edsdoj.ffa680aeab224a5b86c23cf249efddbc |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21479445 25872478 |
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| DOI: | 10.4274/jpr.galenos.2022.56667 |