دورية أكاديمية
A Review of the Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Lean Body Mass in Humans
| العنوان: | A Review of the Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Lean Body Mass in Humans |
|---|---|
| المؤلفون: | Jack Alistair Sargeant, Joseph Henson, James Adam King, Thomas Yates, Kamlesh Khunti, Melanie Jane Davies |
| المصدر: | Endocrinology and Metabolism, Vol 34, Iss 3, Pp 247-262 (2019) |
| بيانات النشر: | Korean Endocrine Society, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, diabetes mellitus, type 2, weight loss, body composition, lean body mass, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Weight loss is an important goal in the management of several chronic conditions, including type 2 diabetes mellitus, and pharmacological therapies that aid weight loss are appealing. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) are novel glucose-lowering therapies that have been shown to induce clinically significant reductions in body weight. However, this weight loss may not be attributed solely to fat mass (FM). Given the importance of skeletal muscle and lean body mass (LBM) on cardio-metabolic health and physical function, we reviewed the available literature reporting the effects of GLP-1RAs and SGLT2is on body composition. Results demonstrate that, in most circumstances, the weight loss associated with both therapies predominantly comprises a reduction in FM, although significant heterogeneity exists between studies. In over half of the studies identified, the proportion of LBM reduction ranged between 20% and 50% of total weight lost, which is consistent with diet-induced weight loss and bariatric surgery. No clear differences existed between GLP-1RAs and SGLT2is. Consequently, the loss of LBM and skeletal muscle associated with weight loss induced by GLP-1RAs and SGLT2is warrants attention. Strategies to preserve skeletal muscle and improve physical function, for example through structured exercise, are of great importance. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2093-596X 2093-5978 |
| العلاقة: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-247.pdfTest; https://doaj.org/toc/2093-596XTest; https://doaj.org/toc/2093-5978Test |
| DOI: | 10.3803/EnM.2019.34.3.247 |
| الوصول الحر: | https://doaj.org/article/1cf3b01d971c41eab6a25daf8739ec89Test |
| رقم الانضمام: | edsdoj.1cf3b01d971c41eab6a25daf8739ec89 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2093596X 20935978 |
|---|---|
| DOI: | 10.3803/EnM.2019.34.3.247 |