المؤلفون: Ariens, Robert, Becattini, Cecilia, Bender, Markus, Bergmeier, Wolfgang, Castoldi, Elisabetta, Devreese, Katrien, Ellis, Martin, Gailani, David, Ignjatovic, Vera, James, Paula D., Kerrigan, Steven, Lambert, Michele, Lee, Lai Heng, Levi, Marcel, Maugeri, Norma, Meijers, Joost, Melero-Martin, Juan, Michelson, Alan D., Mingozzi, Federico, Neeves, Keith, Ni, Heyu, Olsson, Anna-Karin, Prohaszka, Zoltan, Ranson, Marie, Riva, Nicoletta, Senis, Yotis, van Ommen, Cornelia H., Vaughan, Douglas E., Weisel, John

المصدر: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 4(5):680-713

الوصف: The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12-15, 2019, due to the coronavirus disease 2019 pandemic. The congress convenes annually to discuss clinical and basic topics in hemostasis and thrombosis. Each year, the program includes State of Art (SOA) lectures given by prominent scientists. Presenters are asked to create Illustrated Capsules of their talks, which are concise illustrations with minimal explanatory text. Capsules cover major themes of the presentation, and these undergo formal peer review for inclusion in this article. Owing to the shift to a virtual congress this year, organizers reduced the program size. There were 39 SOA lectures virtually presented, and 29 capsules (9 from talks omitted from the virtual congress) were both submitted and successful in peer review, and are included in this article. Topics include the roles of the hemostatic system in inflammation, infection, immunity, and cancer, platelet function and signaling, platelet function disorders, megakaryocyte biology, hemophilia including gene therapy, phenotype tests in hemostasis, von Willebrand factor, anticoagulant factor V, computational driven discovery, endothelium, clinical and basic aspects of thrombotic microangiopathies, fibrinolysis and thrombolysis, antithrombotics in pediatrics, direct oral anticoagulant management, and thrombosis and hemostasis in pregnancy. Capsule authors invite virtual congress attendees to refer to these capsules during the live presentations and participate on Twitter in discussion. Research and Practice in Haemostasis and Thrombosis will release 2 tweets from @RPTHJournal during each presentation, using #IllustratedReview, #CoagCapsule and #ISTH2020. Readers are also welcome to utilize capsules for teaching and ongoing education.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421353Test
https://doi.org/10.1002/rth2.12368Test
https://uu.diva-portal.org/smash/get/diva2:1474313/FULLTEXT01.pdfTest

المؤلفون: Rodriguez, Guadalupe, Eren, Mesut, Haupfear, Isabel, Viola, Kirsten L., Cline, Erika N., Miyata, Toshio, Klein, William L., Vaughan, Douglas E., Dong, Hongxin

المصدر: Psychopharmacology; Dec2023, Vol. 240 Issue 12, p2641-2655, 15p

مصطلحات موضوعية: PLASMINOGEN, PLASMINOGEN activators, MEMORY disorders, AMYLOID beta-protein precursor, ALZHEIMER'S disease, AMYLOID plaque, NEUROLOGICAL disorders

مستخلص: Rationale: Extracellular proteolytic activity plays an important role in memory formation and the preservation of cognitive function. Previous studies have shown increased levels of plasminogen activator inhibitor-1 (PAI-1) in the brain of mouse models of Alzheimer's disease (AD) and plasma of AD patients, associated with memory and cognitive decline; however, the exact function of PAI-1 in AD onset and progression is largely unclear. Objective: In this study, we evaluated a novel PAI-1 inhibitor, TM5A15, on its ability to prevent or reverse memory deficits and decrease Aβ levels and plaque deposition in APP/PS1 mice. Methods: We administered TM5A15 mixed in a chow diet to 3-month and 9-month-old APP/PS1 mice before and after neuropathological changes were distinguishable. We then evaluated the effects of TM5A15 on memory function and neuropathology at 9 months and 18 months of age. Results: In the younger mice, 6 months of TM5A15 treatment protected against recognition and short-term working memory impairment. TM5A15 also decreased oligomer levels and amyloid plaques, and increased mBDNF expression in APP/PS1 mice at 9 months of age. In aged mice, 9 months of TM5A15 treatment did not significantly improve memory function nor decrease amyloid plaques. However, TM5A15 treatment showed a trend in decreasing oligomer levels in APP/PS1 mice at 18 months of age. Conclusion: Our results suggest that PAI-1 inhibition could improve memory function and reduce the accumulation of amyloid levels in APP/PS1 mice. Such effects are more prominent when TM5A15 is administered before advanced AD pathology and memory deficits occur. [ABSTRACT FROM AUTHOR]

: Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Joyce, Brian T, Chen, Xuefen, Gao, Tao, Zheng, Yinan, Nannini, Drew R, Liu, Lei, Henkle, Benjamin E, Kalhan, Ravi, Washko, George, Kunisaki, Ken M, Thyagarajan, Bharat, Vaughan, Douglas E, Gross, Myron, Jacobs Jr, David R, Lloyd-Jones, Donald, Hou, Lifang

المصدر: Epigenomics; Jul2023, Vol. 15 Issue 13, p693-703, 11p

المؤلفون: Eren, Mesut, Boe, Amanda E., Murphy, Sheila B., Place, Aaron T., Nagpal, Varun, Morales-Nebreda, Luisa, Urich, Daniela, Quaggin, Susan E., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2014 May . 111(19), 7090-7095.

الوصول الحر: https://www.jstor.org/stable/23772728Test

المؤلفون: Limbird, Lee E., Vaughan, Douglas E.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1999 Jun . 96(13), 7125-7127.

الوصول الحر: https://www.jstor.org/stable/48022Test

المؤلفون: Williams, Scott M., Stocki, Shelli, Jiang, Lan, Brew, Kwabena, Gordon, Seth, Vaughan, Douglas E., Brown, Nancy J., Poku, Kwabena A., Moore, Jason H.

المصدر: Ethnicity & Disease, 2007 Jul 01. 17(3), 492-497.

الوصول الحر: https://www.jstor.org/stable/48667108Test

المؤلفون: Shaklee, Julia F., Talbot, Thomas R., Muldowney, James A. S., Vaughan, Douglas E., Butler, Javed, House, Frances, Crowe, James E., Smith, L. Harris, Edwards, Kathryn M.

المصدر: The Journal of Infectious Diseases, 2005 Mar 01. 191(5), 724-730.

الوصول الحر: https://www.jstor.org/stable/30077553Test

المؤلفون: Simons, Lacy M, Lorenzo-Redondo, Ramon, Gibson, Meg, Kinch, Sarah L, Vandervaart, Jacob P, Reiser, Nina L, Eren, Mesut, Lux, Elizabeth, McNally, Elizabeth M, Tambur, Anat R, Vaughan, Douglas E, Bachta, Kelly E R, Demonbreun, Alexis R, Satchell, Karla J F, Achenbach, Chad J, Ozer, Egon A, Ison, Michael G, Hultquist, Judd F

المصدر: Open Forum Infectious Diseases; Mar2022, Vol. 9 Issue 3, p1-13, 13p

مصطلحات موضوعية: SARS-CoV-2, CORONAVIRUS diseases, COVID-19

مستخلص: Background While several demographic and clinical correlates of coronavirus disease 2019 (COVID-19) outcome have been identified, their relationship to virological and immunological parameters remains poorly defined. Methods To address this, we performed longitudinal collection of nasopharyngeal swabs and blood samples from a cohort of 58 hospitalized adults with COVID-19. Samples were assessed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load, viral genotype, viral diversity, and antibody titer. Demographic and clinical information, including patient blood tests and several composite measures of disease severity, was extracted from electronic health records. Results Several factors, including male sex, higher age, higher body mass index, higher 4C Mortality score, and elevated lactate dehydrogenase levels, were associated with intensive care unit admission. Of all measured parameters, only the retrospectively calculated median Deterioration Index score was significantly associated with death. While quantitative polymerase chain reaction cycle threshold (Ct) values and genotype of SARS-CoV-2 were not significantly associated with outcome, Ct value did correlate positively with C-reactive protein levels and negatively with D-dimer, lymphocyte count, and antibody titer. Intrahost viral genetic diversity remained constant through the disease course and resulted in changes in viral genotype in some participants. Conclusions Ultimately, these results suggest that worse outcomes are driven by immune dysfunction rather than by viral load and that SARS-CoV-2 evolution in hospital settings is relatively constant over time. [ABSTRACT FROM AUTHOR]

: Copyright of Open Forum Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Khan, Sadiya S., Shah, Sanjiv J., Strande, Jennifer L., Baldridge, Abigail S., Flevaris, Panagiotis, Puckelwartz, Megan J., McNally, Elizabeth M., Rasmussen-Torvik, Laura J., Lee, Daniel C., Carr, James C., Benefield, Brandon C., Afzal, Muhammad Zeeshan, Heiman, Meadow, Gupta, Sweta, Shapiro, Amy D., Vaughan, Douglas E.

المصدر: JAMA Cardiology; Jul2021, Vol. 6 Issue 7, p841-846, 6p

المؤلفون: Levine, Joshua A., Olivares, Shantel, Miyata, Toshio, Vaughan, Douglas E., Henkel, Anne S.

المصدر: Obesity (19307381); Apr2021, Vol. 29 Issue 4, p713-720, 8p

مصطلحات موضوعية: WEIGHT loss, LIPOLYSIS, LOW-fat diet, PLASMINOGEN activator inhibitors, LABORATORY mice

مستخلص: Objective: This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor‐1 (PAI‐1), TM5441, in reversing diet‐induced obesity in mice. Methods: Wild‐type C57BL/6J mice were fed a high‐fat high‐sugar (HFHS) diet for 8 weeks to induce obesity. After the first 8 weeks, TM5441 was added to the diet for an additional 8 weeks. In order to determine the efficacy of PAI‐1 inhibition in conjunction with dietary modification, mice were fed an HFHS diet for 8 weeks to induce obesity and were then switched to a low‐fat diet with or without TM5441 for an additional 2 to 8 weeks. Results: Obese mice showed weight reduction and significant improvement in hepatic steatosis when TM5441 was added to the HFHS diet. Obese mice that were treated with TM5441 in conjunction with dietary modification showed enhanced weight loss and a more rapid reversal of hepatic steatosis compared with obese mice treated with dietary modification alone. The enhanced weight loss among mice treated with TM5441 was associated with increased adipose tissue expression of adipose triglyceride lipase, phosphorylated hormone‐sensitive lipase, and phosphorylated perilipin‐1 as well as induction of adipose tissue lipolysis. Conclusions: Pharmacologic PAI‐1 inhibition stimulates adipose tissue lipolysis and enhances weight loss in obese mice. [ABSTRACT FROM AUTHOR]

: Copyright of Obesity (19307381) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)