المؤلفون: Kucharik, Michael P., Andrews, Reed, John, Mitchell P., Ohanisian, Levonti, Sullivan, Alex, Chebli, Caroline

المصدر: JBJS Case Connector; Oct-Dec2023, Vol. 13 Issue 4, p1-6, 6p

مصطلحات موضوعية: HUMERAL fractures, UNUNITED fractures, PERIPROSTHETIC fractures, REOPERATION, FRACTURE fixation

مستخلص: Case: An 82-year-old man sustained a periprosthetic fracture after IlluminOss photodynamic bone stabilization system (PBSS) stabilization for an impending pathologic fracture. Nonoperative management was unsuccessful, and he subsequently underwent operative fixation, which featured lag screw fixation of the spiral distal humeral shaft fracture and osteotomy followed by plate fixation of the pathologic humeral shaft fracture. Conclusion: This is the first article to report this complication with IlluminOss PBSS stabilization and details regarding revision surgery. [ABSTRACT FROM AUTHOR]

: Copyright of JBJS Case Connector is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Salomon, Kevin, Shen, Victor, Sullivan, Alex, Grayson, Christopher, Lyons, Steven, Palumbo, Brian T.

المصدر: Journal of Orthopaedics; Sep2023, Vol. 43, p6-10, 5p

مصطلحات موضوعية: FEMUR surgery, WORK experience (Employment), TOTAL hip replacement, HOSPITAL medical staff, ORTHOPEDIC surgery, OSTEOTOMY, TIME, PLASTIC surgery, RETROSPECTIVE studies, HEALTH outcome assessment, DESCRIPTIVE statistics, MEDICAL fellowships, COMPLICATIONS of prosthesis

مستخلص: Revision of well-fixed cementless femoral stems is a challenging and time-consuming aspect of revision hip arthroplasty. The Watson Extraction System (WES) is a novel, size-specific 3-D fabricated instrument that mimics the outer geometry of the implanted femoral stem. The device acts to cut circumferentially around the stem as it is impacted into place, effectively disrupting the bone-implant interface. This is a retrospective review assessing the experience of 3 fellowship-trained adult reconstruction surgeons who used the WES to extract 10 well-fixed femoral stems during rTHA between 11/7/2020 and 11/7/2022. Outcomes and measures included: ability to remove the stem without a femoral osteotomy, femoral stem extraction time, incidence of femoral fracture, stem type used for reconstruction, blood loss, total surgical time, post-operative complications. No femoral osteotomies were required. The mean time for stem extraction was 7 min (range, 2–13), and there were 2 (20%) intra-operative femoral fractures. The stem type utilized for reconstruction included: 4 (40%) modular, tapered style stems, 3 (30%) antibiotic spacers, 2 (20%) primary style stems, and 1 (10%) ream and broach proximally porous stem. The mean blood loss was 425 ml (range, 200–800), total surgical time was 160 min (range, 107–232), and duration of follow-up was 7 months (range, 2–22 months). The WES may mitigate the need for femoral osteotomy, reduce femoral stem extraction and overall intraoperative time, and decrease blood loss in rTHA. Further, reduced bone loss with use of this device may permit final reconstruction with a primary style stem. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Orthopaedics is the property of Professor PK Surendran Memorial Education Foundation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Paley, Dror, Lamm, Bradley M., Robbins, Craig, Sullivan, Alex, Ernst, Jordan, Danne Jr., Elvis, Lichtblau, Craig

المصدر: Journal of Foot & Ankle Surgery; Jul2022, Vol. 61 Issue 4, pe15-e20, 6p

مستخلص: We reviewed 18 limbs in 17 patients who underwent ankle fusion with simultaneous tibial lengthening with a magnetic internal lengthening nail. All patients had preoperative limb length discrepancy (LLD) (mean 4.9 cm (2.6-7.6 cm)) with ankle deformity. The ankle was fused from medial or lateral approaches using screws/plate constructs placed adjacent to the retrograde Precise nail. Lengthening was carried out by a distal 1/3 tibial osteotomy. Clinical and radiographic measures were performed after a mean follow-up of 20 months (12-37 months). The mean amount of lengthening performed was 4 cm (1.8-7.2 cm). The final mean LLD was 1 cm (0.7-1.1 cm), which was statistically significant (p <0.01) as compared to preoperative. The foot was plantigrade in all cases. The mean foot rotation was 10° (5-15°) external, relative to the knee. At final follow-up all patients reported minimal to no pain, and all claimed to be walking more functionally than before surgery. Ankle fusion and limb lengthening was achieved in all cases. Combining both treatments by using an internal lengthening nail was very effective and avoided leaving patients with a dysfunctional LLD or of having a separate limb lengthening procedure. This is the first report of such a combined treatment of ankle fusion with internal tibial lengthening nail. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Foot & Ankle Surgery is the property of W B Saunders and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Rymer, Jennifer, Alhanti, Brooke, Kemp, Steven, Bhatt, Deepak, Angiolillo, Dominick, Diaz, Miguel, Garratt, Kirk N., Waksman, Ron, Kirtane, Ajay, Ang, Lawrence, Bach, Richard, Barker, Colin, Jenkins, Ronald, Basir, Mir, Sullivan, Alex, El-Sabae, Hijrah, Brothers, Leo, Washam, Jeff, Ohman, Magnus, Jones, Schuyler

المصدر: JACC: Cardiovascular Interventions; 2023 Supplement 4, Vol. 16 Issue 4, pS14-S14, 1p

المؤلفون: Alter, Scott M., Haim, Eithan D., Sullivan, Alex H., Clayton, Lisa M.

المصدر: American Journal of Emergency Medicine; Oct2018, Vol. 36 Issue 10, p1807-1809, 3p

مستخلص: Objective: Direct laryngoscopy can be performed using curved or straight blades, and providers usually choose the blade they are most comfortable with. However, curved blades are anecdotally thought of as easier to use than straight blades. We seek to compare intubation success rates of paramedics using curved versus straight blades.Methods: Design: retrospective chart review.Setting: hospital-based suburban ALS service with 20,000 annual calls.Subjects: prehospital patients with any direct laryngoscopy intubation attempt over almost 9years. First attempt and overall success rates were calculated for attempts with curved and straight blades. Differences between the groups were calculated.Results: 2299 patients were intubated by direct laryngoscopy. 1865 had attempts with a curved blade, 367 had attempts with a straight blade, and 67 had attempts with both. Baseline characteristics were similar between groups. First attempt success was 86% with a curved blade and 73% with a straight blade: a difference of 13% (95% CI: 9-17). Overall success was 96% with a curved blade and 81% with a straight blade: a difference of 15% (95% CI: 12-18). There was an average of 1.11 intubation attempts per patient with a curved blade and 1.13 attempts per patient with a straight blade (2% difference, 95% CI: -3-7).Conclusions: Our study found a significant difference in intubation success rates between laryngoscope blade types. Curved blades had higher first attempt and overall success rates when compared to straight blades. Paramedics should consider selecting a curved blade as their tool of choice to potentially improve intubation success. [ABSTRACT FROM AUTHOR]

: Copyright of American Journal of Emergency Medicine is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Gasco, Milena, Sullivan, Alex, Repellin, Claire, Brooks, Louise, Farrell, Paul J., Tidy, John A., Dunne, Barbara, Gusterson, Barry, Evans, David J., Crook, Tim

المصدر: Oncogene. 3/14/2002, Vol. 21 Issue 12, p1876. 6p. 3 Black and White Photographs, 1 Chart.

مصطلحات موضوعية: *GENE expression, *SQUAMOUS cell carcinoma, *VULVAR cancer

مستخلص: Presents a study which analyzed the structure and expression of 14-3-3 σ(σ) gene in squamous carcinomas of the vulva and in the vulval pre-malignant lesion vulval intraepithelial neoplasia. Review of related literature; Materials and methods used; Results.

المؤلفون: Wiśniewska, Maria^1,2 (AUTHOR), Laptev, Alexander M.¹ (AUTHOR), Marczewski, Mateusz¹ (AUTHOR), Leshchynsky, Volf¹ (AUTHOR), Lota, Grzegorz^3,4 (AUTHOR), Acznik, Ilona³ (AUTHOR), Celotti, Luca⁵ (AUTHOR), Sullivan, Alex⁵ (AUTHOR), Szybowicz, Mirosław² (AUTHOR), Garbiec, Dariusz¹ (AUTHOR) dariusz.garbiec@pit.lukasiewicz.gov.pl

المصدر: Ceramics International. May2023, Vol. 49 Issue 10, p15442-15450. 9p.

مصطلحات موضوعية: *THERMAL conductivity, *ELECTRIC conductivity, *CERAMIC-matrix composites, *IMPEDANCE spectroscopy, *ZIRCONIUM oxide, *CARBON nanotubes

مستخلص: Carbon nanotubes (CNTs) are widely used in ceramic-matrix composites (CMC) as a filler. An individual carbon nanotube exhibits extremely high thermal conductivity, however, the influence of CNTs on the thermal conductivity of CMCs is moderate. In contrast, even a small quantity of CNTs significantly increases the electrical conductivity of CMCs. The present paper studies this contradictory influence for ZrO 2 -CNTs composites with 3, 5, 10 and 20 vol% multi-wall carbon nanotubes (MWCNTs). Their thermal and electrical conductivity was studied by the laser flash method and electrochemical impedance spectroscopy. The analysis reveals that the moderate influence of MWCNTs on the thermal conductivity of composites originates from the similar thermal conductivity of MWCNTs in a bundle and zirconia. On the other hand, the substantial difference in the electrical conductivity of MWCNTs and zirconia leads to an exponential increase in the electrical conductivity of the ZrO 2 -CNTs composite even with small additions of nanotubes. [ABSTRACT FROM AUTHOR]

المؤلفون: Lu, Min¹, Breyssens, Hilde¹, Salter, Victoria¹, Zhong, Shan¹, Hu, Ying¹, Baer, Caroline¹, Ratnayaka, Indrika¹, Sullivan, Alex¹, Brown, Nicholas?R.², Endicott, Jane², Knapp, Stefan^3,4, Kessler, Benedikt?M.^4,5, Middleton, Mark?R.⁶, Siebold, Christian⁷, Jones, E.?Yvonne⁷, Sviderskaya, Elena?V.⁸, Cebon, Jonathan⁹, John, Thomas⁹, Caballero, Otavia?L.¹⁰, Goding, Colin?R.¹

المصدر: Cancer Cell. May2013, Vol. 23 Issue 5, p618-633. 16p.

مصطلحات موضوعية: *P53 antioncogene, *MELANOMA, *CYCLIN-dependent kinases, *APOPTOSIS inhibition, *PHOSPHORYLATION, *BINDING sites

مستخلص: Summary: Nearly 90% of human melanomas contain inactivated wild-type p53, the underlying mechanisms for which are not fully understood. Here, we identify that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of iASPP dimerization, promotion of iASPP monomer nuclear entry, and exposure of its p53 binding sites, leading to increased p53 inhibition. Nuclear iASPP is enriched in melanoma metastasis and associates with poor patient survival. Most wild-type p53-expressing melanoma cell lines coexpress high levels of phosphorylated nuclear iASPP, MDM2, and cyclin B1. Inhibition of MDM2 and iASPP phosphorylation with small molecules induced p53-dependent apoptosis and growth suppression. Concurrent p53 reactivation and BRAFV600E inhibition achieved additive suppression in vivo, presenting an alternative for melanoma therapy. [Copyright &y& Elsevier]

المؤلفون: Lu, Min, Breyssens, Hilde, Salter, Victoria, Zhong, Shan, Hu, Ying, Baer, Caroline, Ratnayaka, Indrika, Sullivan, Alex, Brown, Nicholas R., Endicott, Jane, Knapp, Stefan, Kessler, Benedikt M., Middleton, Mark R., Siebold, Christian, Jones, E. Yvonne, Sviderskaya, Elena V., Cebon, Jonathan, John, Thomas, Caballero, Otavia L., Goding, Colin R.

المصدر: Cancer Cell. Nov2016, Vol. 30 Issue 5, p822-823. 2p.

مصطلحات موضوعية: *MELANOMA, *P53 antioncogene, *CANCER cells, *CYCLIN-dependent kinases, *PHOSPHORYLATION