التفاصيل البيبلوغرافية
| العنوان: |
Demographic patterns of cutaneous T-cell lymphoma incidence in Texas based on two different cancer registries. |
| المؤلفون: |
Litvinov, Ivan V., Tetzlaff, Michael T., Rahme, Elham, Jennings, Michelle A., Risser, David R., Gangar, Pamela, Netchiporouk, Elena, Moreau, Linda, Prieto, Victor G., Sasseville, Denis, Duvic, Madeleine |
| المصدر: |
Cancer Medicine; Sep2015, Vol. 4 Issue 9, p1440-1447, 8p |
| مصطلحات موضوعية: |
T-cell lymphoma, MYCOSIS fungoides, SEZARY syndrome, LOGISTIC regression analysis, PUBLIC health |
| مصطلحات جغرافية: |
HOUSTON (Tex.), TEXAS |
| مستخلص: |
Cutaneous T-cell lymohomas ( CTCLs) are rare, but potentially devastating malignancies, with Mycosis fungoides and Sézary Syndrome being the most common. In our previous study, we identified and described regions of geographic clustering of CTCL cases in Texas by analyzing ~1990 patients using two distinct cancer registries. In the current work, we describe in detail demographic patterns for this malignancy in our study population and apply logistic regression models to analyze the incidence of CTCL by sex, race, age, and clinical stage at the time of diagnosis. Furthermore, using Fisher's exact test, we analyze changes in incidence over time in the identified Houston communities with unusually high CTCL incidence. While CTCL primarily affects Caucasian individuals >55 years old, we confirm that it presents at a younger age and with more advanced disease stages in African-American and Hispanic individuals. Also, we demonstrate a significant increase in CTCL incidence over time in the identified communities. Spring, Katy, and Houston Memorial areas had high baseline rates. Furthermore, a statistically significant disease surge was observed in these areas after ~2005. This report supplements our initial study documenting the existence of geographic clustering of CTCL cases in Texas and in greater detail describes demographic trends for our patient population. The observed surge in CTCL incidence in the three identified communities further argues that this malignancy may be triggered by one or more external etiologic agents. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder