An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

التفاصيل البيبلوغرافية
العنوان:	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
المؤلفون:	Shensi Shen, Sara Faouzi, Amandine Bastide, Sylvain Martineau, Hélène Malka-Mahieu, Yu Fu, Xiaoxiao Sun, Christine Mateus, Emilie Routier, Severine Roy, Laurent Desaubry, Fabrice André, Alexander Eggermont, Alexandre David, Jean-Yves Scoazec, Stéphan Vagner, Caroline Robert
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
العلاقة:	https://doaj.org/toc/2041-1723Test
DOI:	10.1038/s41467-019-13360-6
الوصول الحر:	https://doaj.org/article/e47491eb7c3744b2a9a1e54104826b8fTest
رقم الانضمام:	edsdoj.47491eb7c3744b2a9a1e54104826b8f
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-13360-6