دورية أكاديمية
The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer
| العنوان: | The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer |
|---|---|
| المؤلفون: | Jeanine Marie Nardin, Werner Schroth, Thais Abreu Almeida, Thomas Mürdter, Solane Picolotto, Evelyn Castillo Lima Vendramini, Reiner Hoppe, Jenifer Primon Kogin, Diandra Miqueleto, Silvia Dark Robaskievicz deMoraes, Matthias Schwab, Roberto Flavio Pecoits‐Filho, Hiltrud Brauch, José Claudio Casali‐da‐Rocha |
| المصدر: | Clinical and Translational Science, Vol 13, Iss 2, Pp 284-292 (2020) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270 |
| الوصف: | Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (liquid‐chromatography tandem mass spectrometry), adherence behavior (Morisky, Green, and Levine medication adherence scale), and cytochrome P450 2D6 (CYP2D6) and other pharmacogene polymorphisms (matrix‐assisted laser‐desorption‐ionization time of flight) mass spectrometry, real‐time polymerase chain reaction). Adherence explained 47% of the variability of tamoxifen plasma concentrations (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1752-8062 1752-8054 |
| العلاقة: | https://doaj.org/toc/1752-8054Test; https://doaj.org/toc/1752-8062Test |
| DOI: | 10.1111/cts.12707 |
| الوصول الحر: | https://doaj.org/article/e0ba7392e0d54d8aae8f092b0631c803Test |
| رقم الانضمام: | edsdoj.0ba7392e0d54d8aae8f092b0631c803 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17528062 17528054 |
|---|---|
| DOI: | 10.1111/cts.12707 |