التفاصيل البيبلوغرافية
| العنوان: |
Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality. |
| المؤلفون: |
Drummond, David, Roy, Charlotte, Cornet, Matthieu, Bucher, Julie, Boussaud, Véronique, Pimpec-Barthes, Françoise Le, Pontailler, Margaux, Raisky, Olivier, Lopez, Vanessa, Barbanti, Claudio, Guillemain, Romain, Renolleau, Sylvain, Grimaud, Marion, Oualha, Mehdi, de Saint Blanquat, Laure, Sermet-Gaudelus, Isabelle |
| المصدر: |
Respiratory Research; 4/29/2024, Vol. 25 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
ADULT respiratory distress syndrome, PEDIATRIC intensive care, INTENSIVE care units, CYSTIC fibrosis, FORCED expiratory volume |
| مستخلص: |
Background: Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU). The objectives of this study were to determine short and medium-term outcomes of children with CF admitted to PICU for acute respiratory failure due to pulmonary exacerbation and to identify prognosis factors. Methods: This retrospective monocentric study included patients less than 18 years old admitted to the PICU of a French university hospital between 2000 and 2020. Cox proportional hazard regression methods were used to determine prognosis factors of mortality or lung transplant. Results: Prior to PICU admission, the 29 patients included (median age 13.5 years) had a severe lung disease (median Forced Expiratory Volume in 1 s percentage predicted at 29%). Mortality rates were respectively 17%, 31%, 34%, 41% at discharge and at 3, 12 and 36 months post-discharge. Survival rates free of lung transplant were 34%, 32%, 24% and 17% respectively. Risk factors associated with mortality or lung transplant using the univariate analysis were female sex and higher pCO2 and chloride levels at PICU admission, and following pre admission characteristics: home respiratory and nutritional support, registration on lung transplant list and Stenotrophomonas Maltophilia bronchial colonization. Conclusion: Children with CF admitted to PICU for acute respiratory failure secondary to pulmonary exacerbations are at high risk of death, both in the short and medium terms. Lung transplant is their main chance of survival and should be considered early. [ABSTRACT FROM AUTHOR] |
|
Copyright of Respiratory Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder