التفاصيل البيبلوغرافية
| العنوان: |
Lack of IFN-gamma 2/2 homozygous genotype independently of recipient age and intensity of conditioning regimen influences the risk of aGVHD manifestation after HLA-matched sibling haematopoietic stem cell transplantation. |
| المؤلفون: |
Mlynarczewska, A., Wysoczanska, B., Karabon, L., Bogunia-Kubik, K., Lange, A. |
| المصدر: |
Bone Marrow Transplantation; Aug2004, Vol. 34 Issue 4, p339-344, 6p |
| مصطلحات موضوعية: |
GRAFT versus host disease, OYSTERCATCHERS, BONE marrow, STEM cell transplantation, POLYMORPHISM (Crystallography), MULTIVARIATE analysis |
| مستخلص: |
Summary:A total of 110 patients (71 adults and 39 children) who received allogeneic haematopoietic stem cell transplantation from HLA-matched sibling donors were studied for the incidence of acute graft-versus-host disease (aGvHD) in relation to IFN-gamma gene microsatellite polymorphism. A strong tendency was observed towards the lower incidence of grades II-IV aGvHD in patients having an IFN-gamma 2/2 genotype as compared to the recipients with other IFN-gamma genotypes (0.12 vs 0.33, P=0.06). This relationship was independent of the intensity of conditioning regimen and diagnosis. IFN-gamma polymorphic features, together with other clinical and biological factors (patient's age, donor-recipient gender, diagnosis, conditioning regimen, transplant material and GvHD prophylaxis), were subjected to multivariate analysis for aGvHD manifestation in order to exclude indirect association of the IFN-gamma 2/2 genotype. In multivariate analysis, myeloablative therapy (OR=11.462, P=0.013), recipient age (OR=4.896, P=0.009) and lack of IFN-gamma 2/2 genotype (OR=4.311, P=0.048) were found to significantly contribute to the development of grade II-IV aGvHD, while type of GvHD prophylaxis showed less-strong influence (OR=2.963, P=0.066). Thus, it appeared that the IFN-gamma 2/2 genotype constituted an independent and protective factor associated with a decreased risk of grade II-IV aGvHD. However, this genotype was not found to be associated with the risk of cGvHD or survival.Bone Marrow Transplantation (2004) 34, 339-344. doi:10.1038/sj.bmt.1704581 Published online 5 July 2004 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
