التفاصيل البيبلوغرافية
| العنوان: |
DoE‐Driven Development of an Organocatalytic Enantioselective Addition of Acetaldehyde to Nitrostyrenes in Water**. |
| المؤلفون: |
Nori, Valeria, Sinibaldi, Arianna, Giorgianni, Giuliana, Pesciaioli, Fabio, Di Donato, Francesca, Cocco, Emanuele, Biancolillo, Alessandra, Landa, Aitor, Carlone, Armando |
| المصدر: |
Chemistry - A European Journal; 4/27/2022, Vol. 28 Issue 24, p1-6, 6p |
| مصطلحات موضوعية: |
ACETALDEHYDE, ENAMINES, WATER use, EXPERIMENTAL design, NITROALKENES |
| مستخلص: |
The development of an enantioselective enamine‐catalysed addition of masked acetaldehyde to nitroalkenes via a rational approach helped to move away from the use of chloroform. The presented research allows the use of water as a reaction medium, therefore improving the industrial relevance of a protocol to access very important pharmaceutical intermediates. Critical to the success is the use of chemometrics‐assisted 'Design of Experiments' (DoE) optimisation during the development of the presented new synthetic approach, which allows to investigate the chemical space in a rational way. [ABSTRACT FROM AUTHOR] |
|
Copyright of Chemistry - A European Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
