التفاصيل البيبلوغرافية
| العنوان: |
Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. |
| المؤلفون: |
Yu, Karl O. A., Lm, Jin S., Molano, Alberto, Dutronc, Yves, Iilarionov, Petr A., Forestier, Claire, Fujiwara, Nagatoshi, Arias, Isa, Miyakem, Sachiko, Yamamura, Takashi, Chang, Young-tae, Besra, Gurdyal S., Porcelli, Steven A. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 3/1/2005, Vol. 102 Issue 9, p3383-3388, 6p |
| مصطلحات موضوعية: |
CERAMIDES, FATTY acids, IMMUNOTHERAPY, T cells, UNSATURATED fatty acids, CELLULAR immunity, LYMPHOCYTES |
| مستخلص: |
A form of a-galactosylceramide, KRN7000, activates CD1d-restricted Vα14-invariant (Va14i) natural killer (NK) T cells and initiates multiple downstream immune reactions. We report that substituting the C26:0 N-acyl chain of KRN7000 with shorter, unsaturated fatty acids modifies the outcome of Vα14i NKT cell activation. One analogue containing a diunsaturated C20 fatty acid (C20:2) potently induced a T helper type 2-biased cytokine response, with diminished IFN-&gama; production and reduced Vα14i NKT cell expansion. C20:2 also exhibited less stringent requirements for loading onto CD1d than KRN7000, suggesting a mechanism for the immunomodulatory properties of this lipid. The differential cellular response elicited by this class of Vα14i NKT cell agonists may prove to be useful in immunotherapeutic applications. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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