التفاصيل البيبلوغرافية
| العنوان: |
Cellular localization of MAGI-1 caspase cleavage products and their role in apoptosis. |
| المؤلفون: |
Ivanova, Saška1, Repnik, Urška1, Banks, Lawrence2, Turk, Vito1, Turk, Boris1 boris.turk@ijs.si |
| المصدر: |
Biological Chemistry. Nov2007, Vol. 388 Issue 11, p1195-1198. 4p. 1 Color Photograph, 1 Diagram, 1 Graph. |
| مصطلحات موضوعية: |
*GUANYLATE cyclase, *APOPTOSIS, *CELL death, *CELL junctions, *CELL communication |
| مستخلص: |
MAGI-1 is a membrane-associated guanylate kinase (MAGUK) protein present at adherent and tight junctions, where it acts as a structural and signaling scaffold. During apoptosis, MAGI-1 is cleaved by caspases at Asp761 into N- and C-terminal cleavage products, allowing further dismantling of the cell junctions, one of the key features of apoptosis. Here, we investigated the cellular distribution and possible proapototic role of MAGI-1 caspase cleavage products. Full-length MAGI-1 exhibited submembrane localization, while the N-terminal caspase cleavage product of MAGI-1 is translocated to the cytosol and the C-terminal caspase cleavage product accumulates in the nucleus. When overexpressed in MDCK cells, both N- and C-terminal MAGI-1 caspase cleavage products exhibited minor proapoptotic activity, although their role in apoptosis is probably more passive. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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