دورية أكاديمية
Deletion of FaeG alleviated Enterotoxigenic Escherichia coli F4ac-induced apoptosis in the intestine
| العنوان: | Deletion of FaeG alleviated Enterotoxigenic Escherichia coli F4ac-induced apoptosis in the intestine |
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| المؤلفون: | Pengpeng Xia, Yunping Wu, Siqi Lian, Guomei Quan, Yiting Wang, Guoqiang Zhu |
| المصدر: | AMB Express, Vol 11, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | SpringerOpen, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biotechnology LCC:Microbiology |
| مصطلحات موضوعية: | Enterotoxigenic Escherichia coli (ETEC) F4ac, FaeG subunit, Apoptosis, Biotechnology, TP248.13-248.65, Microbiology, QR1-502 |
| الوصف: | Abstract Enterotoxigenic Escherichia coli (ETEC) F4ac is a major constraint to the development of the pig industry, which is causing newborn and post-weaning piglets diarrhea. Previous studies proved that FaeG is the major fimbrial subunit of F4ac E. coli and efficient for bacterial adherence and receptor recognition. Here we show that the faeG deletion attenuates both the clinical symptoms of F4ac infection and the F4ac-induced intestinal mucosal damage in piglets. Antibody microarray analysis and the detection of mRNA expression using porcine neonatal jejunal IPEC-J2 cells also determined that the absence of FaeG subunit alleviated the F4ac promoted apoptosis in the intestinal epithelial cells. Thus, targeted depletion of FaeG is still beneficial for the prevention or treatment of F4ac infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2191-0855 |
| العلاقة: | https://doaj.org/toc/2191-0855Test |
| DOI: | 10.1186/s13568-021-01201-z |
| الوصول الحر: | https://doaj.org/article/7de1f925ea744a8e8d21487d49d299fdTest |
| رقم الانضمام: | edsdoj.7de1f925ea744a8e8d21487d49d299fd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21910855 |
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| DOI: | 10.1186/s13568-021-01201-z |