التفاصيل البيبلوغرافية
| العنوان: |
Side effects during chemotherapy predict tumour response in advanced colorectal cancer. |
| المؤلفون: |
Schuell, B.1 birgit.schuell@meduniwien.ac.at, Gruenberger, T.2, Kornek, G. V.1, Dworan, N.1, Depisch, D.3, Lang, F.4, Schneeweiss, B.5, Scheithauer, W.1 |
| المصدر: |
British Journal of Cancer. 10/3/2005, Vol. 93 Issue 7, p744-748. 5p. |
| مصطلحات موضوعية: |
*DRUG therapy, *THERAPEUTICS, *CANCER treatment, *COLON cancer, *CANCER patients, *CANCER, *RESEARCH, *CLINICAL trials, *RESEARCH methodology, *ANTINEOPLASTIC agents, *PROGNOSIS, *MEDICAL cooperation, *EVALUATION research, *COLORECTAL cancer, *TREATMENT effectiveness, *COMPARATIVE studies, *RANDOMIZED controlled trials, *SURVIVAL analysis (Biometry), *LONGITUDINAL method |
| مستخلص: |
To investigate whether a relationship between chemotherapy-associated adverse events and treatment efficacy exists, we have analysed the toxicity, objective response and survival data of 303 patients with advanced colorectal cancer. Patients were divided into two groups: the first with beneficial effect (I, n = 245), and the second with progressive disease (II, n = 58). Differences in terms of incidence rates, type and severity of ad verse events were analysed with univariate and multivariate models. The median number of side effects in group I was 6 vs 4 in group II (OR=1.342; P= 0.0001). An inverse correlation between disease control and treatment tolerance was confirmed when side effects were analysed according to severity and type of treatment-associated toxicities (haematological: P = 0.0005 vs nonhaematological P = 0.0001). When median survival was analysed according to the number of adverse events, it was 10 (95% CI, 3-7), 16 (14-18), and 18 (16-20) months in case of 0-1, 2-5, and > or =6 adverse events, respectively (P = 0.01). In conclusion, the results of this analysis suggest that occurrence of side effects during chemotherapy in advanced colorectal cancer is an independent and reliable prognostic indicator for response and survival. [ABSTRACT FROM AUTHOR] |
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