التفاصيل البيبلوغرافية
| العنوان: |
Association of Alanine Aminotransferase Flares to Hepatitis B Surface Decline During Tenofovir Alone or With Pegylated Interferon Alfa. |
| المؤلفون: |
Perrillo, Robert1 robert.perrillo@bswhealth.org, Lok, Anna S.2, Leonard, Kelsey3, Ghany, Marc G.4, Terrault, Norah5, Belle, Steven H.6, Janssen, Harry L. A.7 |
| المصدر: |
American Journal of Gastroenterology (Lippincott Williams & Wilkins). Nov2023, Vol. 118 Issue 11, p2075-2079. 5p. |
| مصطلحات موضوعية: |
*ALANINE aminotransferase, *HEPATITIS B, *HEPATITIS associated antigen, *HEPATITIS B virus, *TENOFOVIR |
| مستخلص: |
INTRODUCTION: We aimed to determine whether the intensity of alanine aminotransferase (ALT) flares during antiviral therapy is associated with the level of hepatitis B surface antigen (HBsAg) decline. METHODS: Quantitative HBsAg was determined during tenofovir monotherapy or tenofovir plus peginterferon alfa- 2a in 201 participants with hepatitis B e antigen--positive or --negative chronic hepatitis B. A multivariable analysis identified factors associated with a shorter time to reduction in HBsAg. RESULTS: Fifty flares occurred during treatment of which 74% were moderate (ALT >5-10 3 upper limit of normal) or severe (ALT >10 x upper limit of normal). These flares were associated with greater HBsAg decline compared with no flares. Significantly faster times to HBsAg decline >1 log10 IU (P=0.04) and to HBsAg level <100 IU/mL (P = 0.01) were observed with severe flares. DISCUSSIONS: Flare severity is a potentially important factor associated with shorter time to HBsAg reduction. These findings can be useful when evaluating HBsAg response to evolving hepatitis B virus therapies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
