التفاصيل البيبلوغرافية
| العنوان: |
Red Ginseng Reduces Inflammatory Response via Suppression MAPK/P38 Signaling and p65 Nuclear Proteins Translocation in Rats and Raw 264.7 Macrophage. |
| المؤلفون: |
Adam, Gareeballah Osman, Kim, Gi-Beum, Lee, Sei-Jin, Lee, Heeryung, Kang, Hyung-Sub, Kim, Shang-Jin |
| المصدر: |
American Journal of Chinese Medicine; 2019, Vol. 47 Issue 7, p1589-1609, 21p, 5 Charts, 9 Graphs |
| مصطلحات موضوعية: |
INFLAMMATION prevention, ANIMAL experimentation, ANTIOXIDANTS, BIOMARKERS, BLOOD pressure measurement, MEDICAL thermometry, CELL culture, CYTOKINES, ENZYME-linked immunosorbent assay, GINSENG, MACROPHAGES, RESEARCH methodology, MEDICINAL plants, POLYMERASE chain reaction, RATS, STATISTICS, SURVIVAL analysis (Biometry), T-test (Statistics), PLANT extracts, DATA analysis, NUCLEAR proteins, DATA analysis software, LIPOPOLYSACCHARIDES, CELL survival, DESCRIPTIVE statistics, IN vitro studies, ONE-way analysis of variance, SYSTEMIC inflammatory response syndrome, IN vivo studies |
| مستخلص: |
Lipopolysaccharides (LPS) cause systemic inflammatory responses, which are characterized by high mortality and multiple signs, including metabolic disturbances, respiratory acidosis, hypotension, and vital organs disorder. Cytokines secretion and oxidative stress are the main features of the disease. Diagnosis and treatment of systemic inflammation (SI) remain a challenge. Korean Red Ginseng (RG) is one of medicinal herbs that showed a potent anti-oxidant effect. We aimed to study the protective effects of RG on systemic inflammatory response in rats and RAW 264.7 macrophage cells induced by LPS. The rats were treated with water and alcohol extracts of RG for four weeks to prevent the inflammatory response. The result showed that LPS toxin increased morbidity and mortality, and induced liver, kidney, and lung injuries manifested by deteriorated biomarkers. Hypotension, hypomagnesemia, acidosis, and oxidative stress were observed in septic rats. However, RG extracts attenuated liver, kidney, and lung enzymes and metabolites in treated groups via its anti-inflammatory and anti-oxidant properties. Furthermore, RG improved magnesium and blood pressure in the treated groups. RAW 264.7 macrophage cells exposed to LPS disturbance in translocation of p65 and MAPK/p38. Nevertheless, RG-pretreated cells did not significantly alter. In conclusion, RG reduced the rates of mortality and morbidity of treated rats — liver, kidney, and lung injuries were protected in the treated groups through the potentiation of anti-oxidant defense. RG was able to conserve mitochondrial function, inhibiting the activation of MAPK/p38 signaling and suppressing NF- κ B p65 cytoplasm-nucleus transport. Further studies are needed to examine the effects on chronic conditions in animal models and human. [ABSTRACT FROM AUTHOR] |
|
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
