التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens. |
| المؤلفون: |
Zanetti, Flavia Adriana, Zajac, María Paula Del Médico, Taboga, Oscar Alberto, Calamante, Gabriela |
| المصدر: |
Journal of Veterinary Science; Jun2012, Vol. 13 Issue 2, p199-201, 3p, 1 Chart |
| مصطلحات موضوعية: |
INFECTIOUS bursal disease virus, VACCINIA, GENE expression, IMMUNOGENETICS, CHICKEN diseases, RECOMBINANT viruses, VIRAL proteins |
| مستخلص: |
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response by observing the production of anti-IBDV-seroneutralizing antibodies in specific pathogen-free chickens. Besides, as the epitopes of VP2 responsible to induce IBDV-neutralizing antibodies are discontinuous, our results suggest that VP2 protein expressed from MVA-VP2 maintained the correct conformational structure. To our knowledge, this is the first report on the usefulness of MVA-based vectors for developing recombinant vaccines for poultry. [ABSTRACT FROM AUTHOR] |
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