دورية أكاديمية
Abnormalities in personal space and parietal–frontal function in schizophrenia
| العنوان: | Abnormalities in personal space and parietal–frontal function in schizophrenia |
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| المؤلفون: | Holt, Daphne J., Boeke, Emily A., Coombs, Garth, DeCross, Stephanie N., Cassidy, Brittany S., Stufflebeam, Steven, Rauch, Scott L., Tootell, Roger B.H. |
| المصدر: | Holt, Daphne J., Emily A. Boeke, Garth Coombs, Stephanie N. DeCross, Brittany S. Cassidy, Steven Stufflebeam, Scott L. Rauch, and Roger B.H. Tootell. 2015. “Abnormalities in personal space and parietal–frontal function in schizophrenia.” NeuroImage : Clinical 9 (1): 233-243. doi:10.1016/j.nicl.2015.07.008. http://dx.doi.org/10.1016/j.nicl.2015.07.008Test. |
| بيانات النشر: | Elsevier, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | HMS Scholarly Articles |
| مصطلحات موضوعية: | Schizophrenia, Personal space, Faces, Object processing, Parietal cortex, Premotor cortex |
| الوصف: | Schizophrenia is associated with subtle abnormalities in day-to-day social behaviors, including a tendency in some patients to “keep their distance” from others in physical space. The neural basis of this abnormality, and related changes in social functioning, is unknown. Here we examined, in schizophrenic patients and healthy control subjects, the functioning of a parietal–frontal network involved in monitoring the space immediately surrounding the body (“personal space”). Using fMRI, we found that one region of this network, the dorsal intraparietal sulcus (DIPS), was hyper-responsive in schizophrenic patients to face stimuli appearing to move towards the subjects, intruding into personal space. This hyper-responsivity was predicted both by the size of personal space (which was abnormally elevated in the schizophrenia group) and the severity of negative symptoms. In contrast, in a second study, the activity of two lower-level visual areas that send information to DIPS (the fusiform face area and middle temporal area) was normal in schizophrenia. Together, these findings suggest that changes in parietal–frontal networks that support the sensory-guided initiation of behavior, including actions occurring in the space surrounding the body, contribute to social dysfunction and negative symptoms in schizophrenia. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| تدمد: | 2213-1582 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573090/pdfTest/; NeuroImage : Clinical |
| DOI: | 10.1016/j.nicl.2015.07.008 |
| الوصول الحر: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:23473931Test |
| حقوق: | open URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAATest |
| رقم الانضمام: | edshld.1.23473931 |
| قاعدة البيانات: | Digital Access to Scholarship at Harvard (DASH) |
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2015.07.008 |