التفاصيل البيبلوغرافية
| العنوان: |
Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization. |
| المؤلفون: |
Giannini, Andrea, Di Donato, Violante, Sopracordevole, Francesco, Ciavattini, Andrea, Ghelardi, Alessandro, Vizza, Enrico, D'Oria, Ottavia, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Golia D'Augè, Tullio, Cuccu, Ilaria, Serati, Maurizio, Pinelli, Ciro, Bergamini, Alice, Gardella, Barbara, Dell'Acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, D'Ippolito, Giovanni |
| المصدر: |
Vaccines; Mar2023, Vol. 11 Issue 3, p698, 11p |
| مصطلحات موضوعية: |
CONIZATION, HUMAN papillomavirus, CERVICAL intraepithelial neoplasia, SURGICAL margin, SURGICAL excision, UNIVARIATE analysis, MULTIVARIATE analysis |
| مستخلص: |
The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating patients undergoing conization for high-grade cervical lesions. All patients included had both positive surgical margins and experienced HPV persistence at 6 months. Associations were evaluated with Cox proportional hazard regression and summarized using hazard ratio (HR). The charts of 2966 patients undergoing conization were reviewed. Among the whole population, 163 (5.5%) patients met the inclusion criteria, being at high risk due to the presence of positive surgical margins and experiencing HPV persistence. Of 163 patients included, 17 (10.4%) patients developed a CIN2+ recurrence during the 5-year follow-up. Via univariate analyses, diagnosis of CIN3 instead of CIN2 (HR: 4.88 (95%CI: 1.10, 12.41); p = 0.035) and positive endocervical instead of ectocervical margins (HR: 6.44 (95%CI: 2.80, 9.65); p < 0.001) were associated with increased risk of persistence/recurrence. Via multivariate analyses, only positive endocervical instead of ectocervical margins (HR: 4.56 (95%CI: 1.23, 7.95); p = 0.021) were associated with worse outcomes. In this high-risk group, positive endocervical margins is the main risk factor predicting 5-year recurrence. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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