التفاصيل البيبلوغرافية
| العنوان: |
Bladder cancers arise from distinct urothelial sub-populations. |
| المؤلفون: |
Van Batavia, Jason, Yamany, Tammer, Molotkov, Andrei, Dan, Hanbin, Mansukhani, Mahesh, Batourina, Ekaterina, Schneider, Kerry, Oyon, Daniel, Dunlop, Mark, Wu, Xue-Ru, Cordon-Cardo, Carlos, Mendelsohn, Cathy |
| المصدر: |
Nature Cell Biology; Oct2014, Vol. 16 Issue 10, p982-991, 10p, 5 Color Photographs, 1 Diagram |
| مصطلحات موضوعية: |
BLADDER cancer, TRANSITIONAL cell carcinoma, URINARY organ cancer, BASAL cell carcinoma, SKIN cancer |
| مستخلص: |
Bladder cancer is the sixth most common cancer in humans. This heterogeneous set of lesions including urothelial carcinoma (Uca) and squamous cell carcinoma (SCC) arise from the urothelium, a stratified epithelium composed of K5-expressing basal cells, intermediate cells and umbrella cells. Superficial Uca lesions are morphologically distinct and exhibit different clinical behaviours: carcinoma in situ (CIS) is a flat aggressive lesion, whereas papillary carcinomas are generally low-grade and non-invasive. Whether these distinct characteristics reflect different cell types of origin is unknown. Here we show using lineage tracing in a murine model of carcinogenesis that intermediate cells give rise primarily to papillary lesions, whereas K5-basal cells are likely progenitors of CIS, muscle-invasive lesions and SCC depending on the genetic background. Our results provide a cellular and genetic basis for the diversity in bladder cancer lesions and provide a possible explanation for their clinical and morphological differences. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
