التفاصيل البيبلوغرافية
| العنوان: |
A Systematic Search for Structure-Activity Relationships of Skin Contact Sensitizers: Methodology. |
| المؤلفون: |
Benezra, Claude1, Sigman, Caroline C.2, Perry, Linda R.2, Helmes, C. Tucker2, Maibach, Howard I.3 |
| المصدر: |
Journal of Investigative Dermatology. Oct85, Vol. 85 Issue 4, p351-356. 6p. |
| مصطلحات موضوعية: |
*STRUCTURE-activity relationships, *ALLERGENS, *CONTACT dermatitis, *DATABASES, *QUINONE, *GALLIC acid |
| مستخلص: |
A computerized resource for the systematic evaluation of the structure-activity relationships and other aspects of contact allergens is described. This resource consists of a data base of results of contact dermatitis tests and a structural classification scheme for contact allergens that is called a Structure-Activity (S/A) Tree. The data base now contains approximately 2200 test results extracted from the journal Contact Dermatitis (1975-1982) and is continually being expanded. The S/A Tree is being developed to provide an index to structure-activity relationships of contact allergens; 63 structural groups are currently indexed. Analyses of benzoquinones and gallic acid esters are presented as examples of the potential application of this resource to such problems as the identification of potential cross-reactants, appropriate test concentrations and vehicles, and the reliability of available test results. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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