التفاصيل البيبلوغرافية
| العنوان: |
Adipokines as targets in musculoskeletal immune and inflammatory diseases. |
| المؤلفون: |
González-Rodríguez, María1,2 (AUTHOR), Ruiz-Fernández, Clara1,3 (AUTHOR), Cordero-Barreal, Alfonso1,4 (AUTHOR), Ait Eldjoudi, Djedjiga1 (AUTHOR), Pino, Jesus1,5 (AUTHOR) jesus.pino@usc.es, Farrag, Yousof1 (AUTHOR) yousof.farrag.zakaria@sergas.es, Gualillo, Oreste1 (AUTHOR) oreste.gualillo@sergas.es |
| المصدر: |
Drug Discovery Today. Nov2022, Vol. 27 Issue 11, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*ADIPOKINES, *MUSCULOSKELETAL system diseases, *PATHOLOGICAL physiology, *ADIPOSE tissues, *METABOLIC syndrome, *THERAPEUTICS, *CARTILAGE cells |
| مستخلص: |
• Adipose tissue dysfunction is one of the main factors involved in triggering and perpetuating inflammatory response in musculoskeletal diseases. • Adipokines are proteins and peptides prevalently produced by white adipocytes but also by chondrocytes, synoviocytes and immune cells. • Adipokines are closely related to the metabolic syndrome and degenerative pathological changes in musculoskeletal diseases. • Obesity is undoubtedly-one of the major hazards for the development and progression of musculoskeletal inflammatory disease. • Modulating the effects of adipokines on different cell types will be a promising new option for the pharmacological treatment of musculoskeletal diseases. Adipokines are the principal mediators in adipose signaling. Nevertheless, besides their role in energy storage, these molecules can be produced by other cells, such as immune cells or chondrocytes. Given their pleiotropic effects, research over the past few years has also focused on musculoskeletal diseases, showing that these adipokines might have relevant roles in worsening the disease or improving the treatment response. In this review, we summarize recent advances in our understanding of adipokines and their role in the most prevalent musculoskeletal immune and inflammatory disorders. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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