التفاصيل البيبلوغرافية
| العنوان: |
Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells. |
| المؤلفون: |
Ghigo, D., Geromin, D., Franchino, C., Todde, R., Priotto, C., Costamagna, C., Arese, M., Garbarino, G., Pescarmona, G., Bosia, A. |
| المصدر: |
Amino Acids; Sep1996, Vol. 10 Issue 3, p277-281, 5p |
| مستخلص: |
The synthesis of nitric oxide (NO), detected as citrulline production, in human (HUVEC) and murine (tEnd.1) endothelial cells correlated with intracellular GSH. tEnd.1, which exhibited an intracellular GSH level 2.5-fold higher than HUVEC, showed a citrulline production (basally and after ionomycin stimulation) 5-8 times higher than human cells. Ionomycinelicited citrulline synthesis in tEnd.1 cells increased 2.4-fold after loading with GSH, and decreased dose-dependently after GSH depletion. Cell loading with N-(2-mercaptopropionyl)-glycine neither significantly increased citrulline production nor relieved the effect of GSH depletion. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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