Influence of Human Milk on Very Preterms’ Gut Microbiota and Alkaline Phosphatase Activity
| العنوان: | Influence of Human Milk on Very Preterms’ Gut Microbiota and Alkaline Phosphatase Activity |
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| المؤلفون: | Diana Teixeira, Manuela Cardoso, Israel Macedo, Shámila Ismael, Conceição Calhau, Cláudia Marques, Inês Barreiros-Mota, Sara Brito, Esmeralda Pereira, Catarina Durão, Ana Faria, Teresa Tomé, João Araújo, Juliana Morais |
| المساهمون: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), Instituto de Saúde Pública da Universidade do Porto, Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Nutrients Volume 13 Issue 5 Nutrients, Vol 13, Iss 1564, p 1564 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Feces / microbiology, Milk, Human / microbiology, Physiology, Mother’s own milk, Gut flora, Feces, fluids and secretions, 0302 clinical medicine, Beneficial bacteria, Infant, Extremely Premature / physiology, RNA, Ribosomal, 16S, donor human milk, TX341-641, Longitudinal Studies, very preterm neonates, Infant Nutritional Physiological Phenomena, RNA, Ribosomal, 16S / analysis, Very preterm neonates, Bifidobacterium, Nutrition and Dietetics, biology, food and beverages, MAC PED, Infant Formula / microbiology, Infant Formula, Gastrointestinal Microbiome / physiology, Infant, Extremely Premature, Alkaline Phosphatase / metabolism, Necrotizing enterocolitis, Biomarker (medicine), Alkaline phosphatase, Female, MAC DIE, alkaline phosphatase, Gestational Age, Gut microbiota, formula, Article, 03 medical and health sciences, Meconium, 030225 pediatrics, medicine, Humans, Milk, Human, gut microbiota, Nutrition. Foods and food supply, Infant, Newborn, Infant Nutritional Physiological Phenomena / physiology, biology.organism_classification, medicine.disease, mother’s own milk, Gastrointestinal Microbiome, 030104 developmental biology, Formula, Donor human milk, Food Science |
| الوصف: | Funding: This study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização–COMPETE2020, and by National Funds through FCT– Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013). The FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother’s own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at four time points (between the 2nd and the 26th postnatal days. Fecal microbiota was analyzed by RT-PCR and by 16S rRNA sequencing. Fecal ALP activity, a proposed specific biomarker of necrotizing enterocolitis (NEC), was evaluated by spectrophotometry at the 26th postnatal day. A total of 389 fecal samples were analyzed from 117 very preterm neonates. Human milk was positively associated with beneficial bacteria, such as Bifidobacterium, Bacteroides ovatus, and Akkermancia muciniphila, as well as bacterial richness. Neonates fed with human milk during the first week of life had increased Bifidobacterium content and fecal ALP activity on the 26th postnatal day. These findings point out the importance of MOM and DHM in the establishment of fecal microbiota on neonates prematurely delivered. Moreover, these results suggest an ALP pathway by which human milk may protect against NEC. publishersversion published |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a3619839f2c90ca003776ba914fabbTest https://doi.org/10.3390/nu13051564Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....53a3619839f2c90ca003776ba914fabb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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