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1دورية أكاديمية
المؤلفون: Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat, Isabelle Mus-Veteau
المصدر: PLoS ONE, Vol 6, Iss 9, p e23834 (2011)
وصف الملف: electronic resource
العلاقة: http://europepmc.org/articles/PMC3169562?pdf=renderTest; https://doaj.org/toc/1932-6203Test
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2دورية أكاديمية
المؤلفون: Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy, Elsa De Lemos, Florence Bonnaterre, Natacha Bienvenu, Olivier Picolet, Eric Sartori, Denis Bucher, Miriam López-Ramos, Carlos Roca Magadán, Wendy Laenen, Thomas Flower, Patrick Mollat, Olivier Bugaud, Robert Touitou, Anna Pereira Fernandes, Stephanie Lavazais, Alain Monjardet, Monica Borgonovi, Romain Gosmini, Reginald Brys, David Amantini, Steve De Vos, Martin Andrews
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Inorganic Chemistry, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, throughput screening campaign, protein kinase amp, activated protein kinase, immunoregulatory cytokine production, clinical candidate glpg3312, pharmacokinetic investigations led, pharmacokinetic properties, immunoregulatory activities, glpg3312 demonstrated, vivo <, vitro <, threonine kinases, therapeutic potential, subsequent hit, sik inhibitor, mouse models, inducible kinases, dual mechanism
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01428.s001Test
https://figshare.com/articles/journal_contribution/Optimization_of_Selectivity_and_Pharmacokinetic_Properties_of_Salt_Inducible_Kinase_Inhibitors_that_Led_to_the_Discovery_of_Pan-SIK_Inhibitor_GLPG3312/24904973Test -
3دورية أكاديمية
المؤلفون: Franck Brebion (2439052), Romain Gosmini (1738168), Pierre Deprez (1705699), Marie Varin (2479900), Christophe Peixoto (2035117), Luke Alvey (2035129), Hélène Jary (2035114), Natacha Bienvenu (1705657), Nicolas Triballeau (1400671), Roland Blanque (3989681), Céline Cottereaux (9412031), Thierry Christophe (242276), Nele Vandervoort (3989705), Patrick Mollat (206614), Robert Touitou (4376779), Philip Leonard (1621432), Frédéric De Ceuninck (1417306), Iuliana Botez (1701322), Alain Monjardet (3989687), Ellen van der Aar (3989690), David Amantini (232220)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, phase 2, knee OA, 1.5 μ M, DMOAD, hydantoin series, Biochemical activity, cocrystal structure, anticatabolic activity, IC 50, glycosaminoglycan release, disease-modifying osteoarthritis, mouse cartilage explants, NCT, GLPG, aggrecanase ADAMTS, HTS, fluorescence-based assay, AGC ELISA
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المؤلفون: L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
المصدر: Osteoarthritis and Cartilage. 30:291-301
مصطلحات موضوعية: Metalloproteinase, biology, Chemistry, Cartilage, Biomedical Engineering, Osteoarthritis, Pharmacology, medicine.disease, Piperazines, Rats, Glycosaminoglycan, Mice, medicine.anatomical_structure, Rheumatology, Proteoglycan, In vivo, biology.protein, medicine, Animals, Humans, Orthopedics and Sports Medicine, ADAMTS5 Protein, Aggrecan, Aggrecanase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3703c4b9781633c63762275b997650Test
https://doi.org/10.1016/j.joca.2021.08.012Test -
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المؤلفون: Andrew H. Sims, Mattia Capulli, Luca Ventura, Stuart H. Ralston, Aymen I. Idris, Ryan T. Bishop, Antonia Sophocleous, Silvia Marino, Barbara Mognetti, Nadia Rucci, John G. Logan, Patrick Mollat
المصدر: Oncotarget
Marino, S, Bishop, R, Capulli, M, Sophocleous, A, Logan, J, Mollar, P, Mognetti, B, Ventura, L, Sims, A, Rucci, N, Ralston, S & Idris, A 2018, ' Regulation of breast cancer induced bone disease by cancer-specific IKKβ ', Oncotarget . https://doi.org/10.18632/oncotarget.24743Testمصطلحات موضوعية: Bone metastasis, Breast cancer, IKKβ, NFκB, Osteolysis, Oncology, 0301 basic medicine, Bone disease, 03 medical and health sciences, breast cancer, Osteoclast, medicine, skin and connective tissue diseases, bone metastasis, business.industry, Cancer, Osteoblast, medicine.disease, NFKB, Vascular endothelial growth factor A, 030104 developmental biology, medicine.anatomical_structure, osteoclast, osteoblast, Cancer research, osteolysis, business, Research Paper
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d61ed264311ebed2617664761274118Test
https://doi.org/10.18632/oncotarget.24743Test -
6Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis
المؤلفون: John G. Logan, Stuart H. Ralston, Antonia Sophocleous, Aymen I. Idris, Patrick Mollat, Silvia Marino
المصدر: Journal of Biological Chemistry. 290:22049-22060
مصطلحات موضوعية: medicine.medical_specialty, Osteolysis, Blotting, Western, Osteoclasts, Parathyroid hormone, Bone Marrow Cells, Breast Neoplasms, Biochemistry, Bone remodeling, Receptor, Cannabinoid, CB2, Phosphatidylinositol 3-Kinases, Osteogenesis, Osteoclast, Cell Line, Tumor, Internal medicine, Bone cell, medicine, Cannabinoid receptor type 2, Animals, Humans, Molecular Biology, Cells, Cultured, Cell Proliferation, Mice, Knockout, Osteoblasts, biology, Cannabinoids, Chemistry, RANK Ligand, Osteoblast, Cell Biology, medicine.disease, Coculture Techniques, Endocrinology, medicine.anatomical_structure, Parathyroid Hormone, RANKL, Culture Media, Conditioned, MCF-7 Cells, biology.protein, lipids (amino acids, peptides, and proteins), Proto-Oncogene Proteins c-akt, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43397953d0a793542d763caa8f88f6bTest
https://doi.org/10.1074/jbc.m115.649608Test -
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المؤلفون: John G. Logan, P. Del Soldato, S.H. Ralston, Patrick Mollat, J Frantzias, Anna Sparatore, Aymen I. Idris
المصدر: British Journal of Pharmacology. 165:1914-1925
مصطلحات موضوعية: musculoskeletal diseases, Pharmacology, Osteolysis, Chemistry, Cellular differentiation, Cancer, Osteoblast, IκB kinase, medicine.disease, medicine.anatomical_structure, Osteoclast, Apoptosis, Immunology, Cancer research, medicine, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::523f7bd2655a9e698a1ef8184f223b7aTest
https://doi.org/10.1111/j.1476-5381.2011.01704.xTest -
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المؤلفون: C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse
المصدر: Osteoarthritis and Cartilage. 25:S58-S59
مصطلحات موضوعية: 030203 arthritis & rheumatology, 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, business.industry, ADAMTS, Biomedical Engineering, Medicine, Orthopedics and Sports Medicine, Pharmacology, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ea7e1f012cfa0b4d04832d440fb14Test
https://doi.org/10.1016/j.joca.2017.02.106Test -
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المؤلفون: Damien Fleury, Catherine Robin-Jagerschmidt, Francois Nique, Patrick Mollat, Thierry Prangé, Maxime Thauvin
المصدر: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 64:1159-1162
مصطلحات موضوعية: Stereochemistry, Biophysics, Endogeny, Peptide, urologic and male genital diseases, Crystallography, X-Ray, Ligands, Biochemistry, Protein structure, Structural Biology, Coactivator, Genetics, Humans, Molecule, Binding site, Receptor, chemistry.chemical_classification, Binding Sites, Condensed Matter Physics, Protein Structure, Tertiary, Androgen receptor, chemistry, Receptors, Androgen, Crystallization Communications, Crystallization, Peptides
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c926194314729fdd7b629354a1e8675Test
https://doi.org/10.1107/s1744309108036683Test -
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المؤلفون: Ramachandran Murali, Masaji Ishiguro, Hiroaki Saito, Mariko Takahashi, Pierre Deprez, Roland Baron, Roland Blanque, Tatsuya Shibata, Masako Yoshimatsu, William C. Horne, Kazuhiro Aoki, Akira Yamaguchi, Cecile Itzstein, Patrick Mollat, Keiichi Ohya, Anower Hussain Mian, Yoshifumi Suzuki
المصدر: Journal of Clinical Investigation. 116:1525-1534
مصطلحات موضوعية: Male, Models, Molecular, musculoskeletal diseases, medicine.medical_specialty, Protein Conformation, Ovariectomy, Molecular Sequence Data, Osteoclasts, Receptors, Cytoplasmic and Nuclear, Receptors, Tumor Necrosis Factor, Bone resorption, Cell Line, Mice, Osteoprotegerin, Osteoclast, Internal medicine, medicine, Animals, Amino Acid Sequence, Bone Resorption, Receptor, Cells, Cultured, Glycoproteins, Mice, Knockout, Lumbar Vertebrae, Membrane Glycoproteins, Receptor Activator of Nuclear Factor-kappa B, biology, Tumor Necrosis Factor-alpha, Chemistry, Activator (genetics), RANK Ligand, General Medicine, Cell biology, Calcium, Dietary, Mice, Inbred C57BL, medicine.anatomical_structure, Endocrinology, RANKL, biology.protein, Female, Signal transduction, Carrier Proteins, Peptides, Sequence Alignment, Signal Transduction, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f60903ba06b381ddb8801ba3798bf82Test
https://doi.org/10.1172/jci22513Test