Overdose of the HIV Medicine Genvoya® in Two Auto-Intoxications
| العنوان: | Overdose of the HIV Medicine Genvoya® in Two Auto-Intoxications |
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| المؤلفون: | Celine Gys, Olivier Mortelé, Babette van Rafelghem, Eleanor Berry, Alexander L N van Nuijs, Willy Lambert, Werner Jacobs, Sofie Schouwers, Anissa Meskal, Ellen Van Hemeldonck, Luc Heytens, Hugo Neels, Adrian Covaci |
| المصدر: | Journal of analytical toxicology |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Chemistry, Chemical Health and Safety, Pharmacology. Therapy, Health, Toxicology and Mutagenesis, Environmental Chemistry, Toxicology, Analytical Chemistry |
| الوصف: | Toxicological data on overdose with human immunodeficiency virus inhibitors are scarce. We present a case report of two independent suicide attempts by self-administered overdose with the same antiretroviral medicine Genvoya® (emtricitabine/elvitegravir/tenofovir alafenamide/cobicistat). Both patients were admitted to the hospital and presented with a loss of consciousness, lactic acidosis, elevated hepatic transaminase levels and hemodynamic instability. While one patient survived with advanced supportive measures, the other passed away. Emtricitabine levels were measured in vivo in various consecutive serum samples and postmortem urine, peripheral and cardiac serum samples and confirmed excessive use in both cases. This is the first time that emtricitabine levels following overdose are reported. Although measured concentrations for emtricitabine were quite similar in these cases, metabolic acidosis was more pronounced in the fatal case. The difference in outcomes between the two could be due to a difference in physiological status, susceptibility to accumulation and adverse effects, and perhaps a varying interval between ingestion and the start of supportive measures. |
| تدمد: | 1945-2403 0146-4760 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5bcaf86fba7b4333e71b6569690396Test https://doi.org/10.1093/jat/bkac056Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f5bcaf86fba7b4333e71b6569690396 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19452403 01464760 |
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