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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

التفاصيل البيبلوغرافية
العنوان: Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
المؤلفون: Florence Menegaux, William J. Blot, Henrik Grönberg, Luc Multigner, Sune F. Nielsen, Stella Koutros, Frank Claessens, Manuela Gago-Dominguez, Kathryn L. Penney, Tyler M. Seibert, Cezary Cybulski, Jennifer J. Hu, Hermann Brenner, Radka Kaneva, Sue A. Ingles, Catherine M. Tangen, Ian G. Mills, Janet L. Stanford, Karina Dalsgaard Sørensen, Ruth C. Travis, Marie-Élise Parent, Monique J. Roobol, Nora Pashayan, Jyotsna Batra, Maria Elena Martinez, Anders M. Dale, Wei Zheng, Kay-Tee Khaw, Chad D. Huff, Chun Chieh Fan, Paul A. Townsend, Kim De Ruyck, Yong-Jie Lu, Eli Marie Grindedal, Hardev Pandha, Sonja I. Berndt, Susan L. Neuhausen, Alicja Wolk, Apcb, Wesley K. Thompson, Maureen Sanderson, Demetrius Albanes, Stephen N. Thibodeau, Christiane Maier, Kenneth Muir, Robin J. Leach, Børge G. Nordestgaard, Ole A. Andreassen, Fredrik Wiklund, Graham G. Giles, Zsofia Kote-Jarai, Catharine M L West, Minh-Phuong Huynh-Le, Manolis Kogevinas, Manuel R. Teixeira, Jong Y. Park, Johanna Schleutker, Marija Gamulin, Freddie C. Hamdy, William S. Bush, Barry S. Rosenstein, Stephen Watya, Roshan Karunamuni, Richard M. Martin, Nc-La PCaP Investigators, Ana Vega, Adam S. Kibel, Lisa A. Cannon-Albright, Azad Hassan Abdul Razack, Esther M. John, Christopher J. Logothetis, Jay H. Fowke, Nawaid Usmani, David E. Neal, Canary Pass Investigators, Rosalind A. Eeles, Robert J. Hamilton, Lisa F. Newcomb, Jenny L Donovan, Olivier Cussenot, Lorelei A. Mucci
المساهمون: University of California [San Diego] (UC San Diego), University of California, The institute of cancer research [London], University of Manchester [Manchester], University of Turku, Centre for Cancer Genetic Epidemiology [Cambridge], Department of Oncology-University of Cambridge [UK] (CAM), University College of London [London] (UCL), Centre de Recherche pour les Pathologies Prostatiques [Paris] (CeRePP), Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), This study was funded in part by a grant from the United States National Institute of Health/National Institute of Biomedical Imaging and Bioengineering (#K08EB026503), United States Department of Defense (#W81XWH-13-1-0391), University of California CRCC C21CR2060, the Research Council of Norway (#223273), K.G. Jebsen Stiftelsen, and South East Norway Health Authority. RM Martin is supported in part by the National Institute for Health Research Bristol Biomedical Research Centre. The CAP trial is funded by Cancer Research UK and the UK Department of Health (C11043/A4286, C18281/A8145, C18281/A11326, C18281/A15064, and C18281/A24432). R.M. Martin was supported by a Cancer Research UK (C18281/A19169) program grant (the Integrative Cancer Epidemiology Programme). Funding for the PRACTICAL consortium member studies is detailed in the Supplementary Information., University of California (UC), University of Cambridge [UK] (CAM)-Department of Oncology, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Huynh-Le, Minh-Phuong [0000-0002-5025-4709], Fan, Chun Chieh [0000-0001-9437-2128], Eeles, Rosalind A [0000-0002-3698-6241], Muir, Kenneth [0000-0001-6429-988X], Schleutker, Johanna [0000-0002-1863-0305], Pashayan, Nora [0000-0003-0843-2468], Batra, Jyotsna [0000-0003-4646-6247], Grönberg, Henrik [0000-0002-1073-2753], Martin, Richard M [0000-0002-7992-7719], Nordestgaard, Børge G [0000-0002-1954-7220], Wiklund, Fredrik [0000-0002-4623-0544], Giles, Graham G [0000-0003-4946-9099], Wolk, Alicja [0000-0001-7387-6845], Travis, Ruth C [0000-0002-9571-0763], Zheng, Wei [0000-0003-1226-070X], West, Catharine ML [0000-0002-0839-3449], Sørensen, Karina Dalsgaard [0000-0002-4902-5490], Park, Jong Y [0000-0002-6384-6447], Vega, Ana [0000-0002-7416-5137], Teixeira, Manuel R [0000-0002-4896-5982], Multigner, Luc [0000-0003-3205-8568], Cannon-Albright, Lisa [0000-0003-2602-3668], Gamulin, Marija [0000-0003-2431-7910], Bush, William S [0000-0002-9729-6519], Roobol, Monique J [0000-0001-6967-1708], Andreassen, Ole A [0000-0002-4461-3568], Seibert, Tyler M [0000-0002-4089-7399], Apollo - University of Cambridge Repository, Clinical Chemistry
المصدر: Nature communications, vol 12, iss 1
APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, The IMPACT Study Steering Committee and Collaborators, Canary PASS Investigators, The Profile Study Steering Committee, The Practical Consortium & UKGPCS Collaborators 2021, ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ', Nature Communications, vol. 12, no. 1, 1236 . https://doi.org/10.1038/s41467-021-21287-0Test
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Huynh-Le, M-P, Fan, C C, Karunamuni, R, Thompson, W K, Martinez, M E, Eeles, R A, Kote-Jarai, Z, Muir, K, Schleutker, J, Pashayan, N, Batra, J, Grönberg, H, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nielsen, S F, Nordestgaard, B G, Wiklund, F, Tangen, C M, Giles, G G, Wolk, A, Albanes, D, Travis, R C, Blot, W J, Zheng, W, Sanderson, M, Stanford, J L, Mucci, L A, West, C M L, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Menegaux, F, Khaw, K-T, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Thibodeau, S N, Rosenstein, B S, Lu, Y-J, Watya, S, Vega, A, Kogevinas, M, Penney, K L & UKGPCS collaborators 2021, ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ', Nature Communications, vol. 12, no. 1, 1236 . https://doi.org/10.1038/s41467-021-21287-0Test
UKGPCS Collaborators 2021, ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ', Nature Communications, vol. 12, no. 1, 1236 . https://doi.org/10.1038/s41467-021-21287-0Test
Huynh-Le, M-P, Fan, C C, Karunamuni, R, Thompson, W K, Martinez, M E, Eeles, R A, Kote-Jarai, Z, Muir, K, Schleutker, J, Pashayan, N, Batra, J, Grönberg, H, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Nielsen, S F, Nordestgaard, B G, Wiklund, F, Tangen, C M, Giles, G G, Wolk, A, Albanes, D, Travis, R C, Blot, W J, Zheng, W, Sanderson, M, Stanford, J L, Mucci, L A, West, C M L, Kibel, A S, Cussenot, O, Berndt, S I, Koutros, S, Sørensen, K D, Cybulski, C, Grindedal, E M, Menegaux, F, Khaw, K-T, Park, J Y, Ingles, S A, Maier, C, Hamilton, R J, Thibodeau, S N, Rosenstein, B S, Lu, Y-J, Watya, S, Vega, A, Kogevinas, M, Penney, K L, Huff, C, Teixeira, M R, Multigner, L, Leach, R J, Cannon-Albright, L, Brenner, H, John, E M, Kaneva, R, Logothetis, C J, Neuhausen, S L, De Ruyck, K, Pandha, H, Razack, A, Newcomb, L F, Fowke, J H, Gamulin, M, Usmani, N, Claessens, F, Gago-Dominguez, M, Townsend, P A, Bush, W S, Roobol, M J, Parent, M-É, Hu, J J, Mills, I G, Andreassen, O A, Dale, A M, Seibert, T M, collaborators, UKGPCS, BioResource), APCB A P C, Investigators, NC-LA PC, Collaborators, T IMPACT S S C A, Investigators, C PASS, Committee, T P S S & Consortium, T PRACTICAL 2021, ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ', Nature Communications, vol. 12, 1236 . https://doi.org/10.1038/s41467-021-21287-0Test
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.1236. ⟨10.1038/s41467-021-21287-0⟩
Nature Communications, 2021, 12 (1), pp.1236. ⟨10.1038/s41467-021-21287-0⟩
Nature Communications, 12(1):1236. Nature Publishing Group
Huynh-Le, M-P, Donovan, J L, Martin, R M, Seibert, T M & al., E 2021, ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ', Nature Communications, vol. 12, no. 1, 1236, pp. 1236 (2021) . https://doi.org/10.1038/s41467-021-21287-0Test
بيانات النشر: eScholarship, University of California, 2021.
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Multifactorial Inheritance, Aging, Multivariate analysis, Ethnic Groups/genetics, General Physics and Astronomy, UKGPCS collaborators, Prostate cancer, 0302 clinical medicine, Urologi och njurmedicin, Ethnicity, risk factors, PRACTICAL Consortium, genetics, Stage (cooking), AgedEthnic Groups / genetics, Cancer, Multidisciplinary, Manchester Cancer Research Centre, Prostatic Neoplasms/genetics, Prostate Cancer, Hazard ratio, APCB, Middle Aged, Hazard, Health equity, 3. Good health, Multidisciplinary Sciences, 030220 oncology & carcinogenesis, Science & Technology - Other Topics, polygenic hazard score (PHS1), prostate cancer, ICEP, Medical Genetics, Urologic Diseases, medicine.medical_specialty, hazard, precision medicine, Science, Prostatic Neoplasms / genetics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Ethnic Groups, survival, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Medical research, SDG 3 - Good Health and Well-being, Internal medicine, NC-LA PCaP Investigators, Genetic model, medicine, Urology and Nephrology, Humans, Neoplasm Invasiveness, Multifactorial Inheritance/genetics, Medicinsk genetik, Aged, Canary PASS Investigators, Science & Technology, IMPACT Study Steering Committee and Collaborators, business.industry, Profile Study Steering Committee, ResearchInstitutes_Networks_Beacons/mcrc, Prostatic Neoplasms, General Chemistry, medicine.disease, Multifactorial Inheritance / genetics, 030104 developmental biology, Multivariate Analysis, Self Report, business, Biomarkers
الوصف: Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p
A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.
وصف الملف: application/pdf; text/xml; application/zip; Electronic
تدمد: 2041-1723
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2599822b66c464be56baaf75fc349c7Test
https://escholarship.org/uc/item/6g41x9nqTest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....a2599822b66c464be56baaf75fc349c7
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20411723