Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
| العنوان: | Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation |
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| المؤلفون: | Suresh Ramakrishna, Roya Rasaei, Kye Seong Kim, Neha Sarodaya, Seok Ho Hong |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 8090, p 8090 (2020) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Inflammation, Review, RIG-I-like receptor, Catalysis, Deubiquitinating enzyme, lcsh:Chemistry, Inorganic Chemistry, Immune system, E3 ligases, Toll-like receptor, medicine, Animals, Humans, NOD-like receptor, Physical and Theoretical Chemistry, innate immunity, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Innate immune system, biology, Ubiquitin, Organic Chemistry, Ubiquitination, Pattern recognition receptor, DUB inhibitors, General Medicine, Immunity, Innate, macrophages, Computer Science Applications, Cell biology, lcsh:Biology (General), lcsh:QD1-999, Virus Diseases, Receptors, Pattern Recognition, Viruses, biology.protein, medicine.symptom |
| الوصف: | Ubiquitination and deubiquitination play a fundamental role in the signaling pathways associated with innate and adaptive immune responses. Macrophages are key sentinels for the host defense, triggering antiviral and inflammatory responses against various invading pathogens. Macrophages recognize the genetic material of these pathogens as pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) through the activation of its pattern recognition receptors (PRRs), initiating the cascade of immune signaling, which leads to the production of pro- and anti-inflammatory cytokines that initiates the appropriate immune response. Macrophage-mediated immune response is highly regulated and tightly controlled by the ubiquitin system since its abnormal activation or dysregulation may result in the severe pathogenesis of numerous inflammatory and autoimmune diseases. Deubiquitinating enzymes (DUBs) play a crucial role in reversing the ubiquitination and controlling the magnitude of the immune response. During infection, pathogens manipulate the host defense system by regulating DUBs to obtain nutrients and increase proliferation. Indeed, the regulation of DUBs by small molecule inhibitors has been proposed as an excellent way to control aberrant activation of immune signaling molecules. This review is focused on the complex role of DUBs in macrophage-mediated immune response, exploring the potential use of DUBs as therapeutic targets in autoimmune and inflammatory diseases by virtue of small molecule DUB inhibitors. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587b0190e86b921829c78fd2357e8e4eTest https://doi.org/10.3390/ijms21218090Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....587b0190e86b921829c78fd2357e8e4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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