Insulin, glucagon and growth hormone in primary adult myxoedema
| العنوان: | Insulin, glucagon and growth hormone in primary adult myxoedema |
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| المؤلفون: | G. Menzinger, M. Iavicoli, D. Andreani, G. Tamburrano, F. Fallucca |
| المصدر: | Diabetologia. 10:7-12 |
| بيانات النشر: | Springer Science and Business Media LLC, 1974. |
| سنة النشر: | 1974 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Arginine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Enteroglucagon, Hypoglycemia, Glucagon, Insulin resistance, Internal medicine, Myxedema, Internal Medicine, medicine, Humans, Insulin, Antiserum, business.industry, Insulin tolerance test, Glucose Tolerance Test, medicine.disease, Endocrinology, Growth Hormone, Female, Insulin Resistance, business |
| الوصف: | Previous studies have shown that in patients with primary adult myxoedema (PAM) the rise in blood glucose (BG) and plasma insulin (IRI) after various stimuli is higher and more sustained than in normals, so that in this condition insulin resistance may be hypothesized. In the search for factors involved glucose (BG), insulin (IRI), glucagon (IRG), (assayed with an antiserum which is not specific for pancreatic glucagon) and growth hormone (GH), have been determined in blood during the oral glucose tolerance test, OGTT, (100 g), arginine intravenous infusion, ATT (30 g/30 min), and insulin-induced hypoglycemia, ITT (0.1 kg), in patients with PAM, without clinical diabetes, and in normal control subjects. During OGTT, glucose and IRI levels were higher than normal; on the other hand, IRG (probably gut glucagon, or enteroglucagon) levels were lower than in normals. During ATT blood glucose in PAM was slightly higher than normal at 30′ and lower at 90′ and 120′; insulin levels were higher than normal at any time; GH and IRG (very likely pancreatic glucagon, or nesidioglucagon) responses were lower than normal. During ITT, blood glucose levels dropped slowly but progressively and GH levels were lower than normal. It is concluded that in primary adult myxoedema glucagon, both enteric and pancreatic, and growth hormone secretions are impaired. The resistance to insulin action observed in PAM does not seem to be due to an excess of growth hormone or (nesidioglucagon). |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf1d130f90411c52fc250fa16a913aTest https://doi.org/10.1007/bf00421407Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....babf1d130f90411c52fc250fa16a913a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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