Preventive effect and possible mechanisms of ultrashort wave diathermy on myogenic contracture in a rabbit model
| العنوان: | Preventive effect and possible mechanisms of ultrashort wave diathermy on myogenic contracture in a rabbit model |
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| المؤلفون: | Feng Wang, Quan-Bing Zhang, Qi-Yu Xu, Yun Zhou, A-Ying Liu |
| المصدر: | Science Progress. 104:003685042110549 |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Myogenic differentiation, Contracture, Multidisciplinary, Knee Joint, business.industry, Ultrashort wave diathermy, MyoD, Muscle atrophy, Muscular Atrophy, Diathermy, Anesthesia, Rabbit model, Animals, Medicine, Rabbits, Range of Motion, Articular, medicine.symptom, Muscle, Skeletal, business, Range of motion, Joint immobilization |
| الوصف: | The purpose of this study was to determine the preventive effect of ultrashort wave diathermy on immobilization-induced myogenic contracture and to explore its underlying mechanisms. Forty-two rabbits were randomly assigned into control (Group C), immobilization (Group I, which was further divided into one week, Group I-1; two weeks, Group I-2; and four weeks, Group I-4, subgroups by the length of immobilization) and ultrashort wave prevention (Group U, which was further divided into one week, Group U-1; two weeks, Group U-2; and four weeks, Group U-4, by time of treatment) groups. Intervention effects were assessed by evaluating rectus femoris cross-sectional area (CSA), knee range of motion, and the protein levels for myogenic differentiation (MyoD) and muscle atrophy F-box (MAFbx-1) in the rectus femoris. Compared with those of Group C, in Groups I and U, total contracture, myogenic contracture, MyoD and MAFbx-1 levels were significantly elevated, and CSA was significantly smaller ( p < 0.05). Compared with those of Group I at each time point, MyoD levels were significantly elevated, MAFbx-1 levels were significantly lower, CSA was significantly larger, and myogenic contracture was significantly alleviated in Group U ( p < 0.05). In the early stages of contracture, ultrashort wave diathermy reduces muscle atrophy and delays the process of myogenic contracture during joint immobilization; the mechanism of this may be explained as increased expression of MyoD triggered by suppression of the MAFbx-1-mediated ubiquitin-proteasome pathway. |
| تدمد: | 2047-7163 0036-8504 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd5f05a7055cfa88c7b630984894d21Test https://doi.org/10.1177/00368504211054992Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dcd5f05a7055cfa88c7b630984894d21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20477163 00368504 |
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