The SPARC DRC: Building a Resource for the Autonomic Nervous System Community
| العنوان: | The SPARC DRC: Building a Resource for the Autonomic Nervous System Community |
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| المؤلفون: | Mahyar Osanlouy, Anita Bandrowski, Bernard de Bono, David Brooks, Antonino M. Cassarà, Richard Christie, Nazanin Ebrahimi, Tom Gillespie, Jeffrey S. Grethe, Leonardo A. Guercio, Maci Heal, Mabelle Lin, Niels Kuster, Maryann E. Martone, Esra Neufeld, David P. Nickerson, Elias G. Soltani, Susan Tappan, Joost B. Wagenaar, Katie Zhuang, Peter J. Hunter |
| المصدر: | Frontiers in Physiology, Vol 12 (2021) Frontiers in Physiology, 12 Frontiers in Physiology |
| بيانات النشر: | eScholarship, University of California, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Computer science, Physiology, Interface (computing), Medical Physiology, computational life sciences, Bioengineering, Resource center, 03 medical and health sciences, Upload, 0302 clinical medicine, Resource (project management), Physiology (medical), Methods, QP1-981, Psychology, Segmentation, FAIR, data curation, Information retrieval, Data curation, business.industry, autonomic nervous system, Semantic search, Neurosciences, Experimental data, SPARC, neural mapping, knowledge management, Data portal, 030104 developmental biology, data annotation, business, 030217 neurology & neurosurgery |
| الوصف: | The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, and simulation tools for the mammalian autonomic nervous system. The experimental data and mathematical models supplied to the DRC by the SPARC consortium are curated, annotated and semantically linked via a single knowledgebase. A data portal has been developed that allows discovery of data and models both via semantic search and via an interface that includes Google Map-like 2D flatmaps for displaying connectivity, and 3D anatomical organ scaffolds that provide a common coordinate framework for cross-species comparisons. We discuss examples that illustrate the data pipeline, which includes data upload, curation, segmentation (for image data), registration against the flatmaps and scaffolds, and finally display via the web portal, including the link to freely available online computational facilities that will enable neuromodulation hypotheses to be investigated by the autonomic neuroscience community and device manufacturers. Frontiers in Physiology, 12 ISSN:1664-042X |
| وصف الملف: | application/pdf; application/application/pdf |
| تدمد: | 1664-042X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b94654cd5b69736de7e07d2030a3d67Test https://escholarship.org/uc/item/5dh65320Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b94654cd5b69736de7e07d2030a3d67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1664042X |
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