Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services
| العنوان: | Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services |
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| المؤلفون: | J. Simon Bell, Maarit Jaana Korhonen, Edwin C.K. Tan, Janet K. Sluggett, Ivanka Hendrix, Leonie Robson, Tina Cooper, Amy Page, Renuka Visvanathan |
| المساهمون: | Hendrix, Ivanka, Page, Amy T, Korhonen, Maarit J, Bell, J Simon, Tan, Edwin CK, Visvanathan, Renuka, Cooper, Tina, Robson, Leonie, Sluggett, Janet K |
| المصدر: | Drugs-Real World Outcomes Drugs-Real World Outcomes, Vol 6, Iss 3, Pp 105-113 (2019) |
| بيانات النشر: | Springer International Publishing, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cross-sectional study, medicine.drug_class, aged care, lcsh:RS1-441, Proton-pump inhibitor, Disease, Logistic regression, 030226 pharmacology & pharmacy, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Internal medicine, Medicine, Pharmacology (medical), 030212 general & internal medicine, Original Research Article, Adverse effect, business.industry, lcsh:RM1-950, Odds ratio, Confidence interval, lcsh:Therapeutics. Pharmacology, proton pump inhibitors, business |
| الوصف: | Aim: While proton pump inhibitors (PPIs) are generally considered safe and well tolerated, frail older people who take PPIs long term may be susceptible to adverse events. This study characterized PPI use and determined factors associated with high-dose use among older adults in residential aged care services (RACSs). Methods: A cross-sectional study of 383 residents of six South Australian RACSs within the same organization was conducted.Clinical, diagnostic, and medication data were collected by study nurses. The proportions of residents who took a PPI for > 8 weeks and without documented indications were calculated. Factors associated with high-dose PPI use compared to standard/low doses were identified using age- and sex-adjusted logistic regression models. Results: 196 (51%) residents received a PPI, with 45 (23%) prescribed a high dose. Overall, 173 (88%) PPI users had documented clinical indications or received medications that can increase bleeding risk. Three-quarters of PPI users with gastroesophageal reflux disease or dyspepsia had received a PPI for > 8 weeks. High-dose PPI use was associated with increasing medication regimen complexity [odds ratio (OR) 1.02; 95% confidence interval (CI) 1.01–1.04 per one-point increase in Medication Regimen Complexity Index score] and a greater number of medications prescribed for regular use (OR 1.11;95% CI 1.01–1.21 per additional medication). Conclusions: Half of all residents received a PPI, of whom the majority had documented clinical indications or received medications that may increase bleeding risk. There remains an opportunity to review the continuing need for treatment and consider “step-down” approaches for high-dose PPI users. Refereed/Peer-reviewed |
| اللغة: | English |
| تدمد: | 2198-9788 2199-1154 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a119f183cca0706cb6ac38317f22edTest http://europepmc.org/articles/PMC6702506Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....10a119f183cca0706cb6ac38317f22ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21989788 21991154 |
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