Sleep dysregulation, memory impairment, and CSF biomarkers during different levels of neurocognitive functioning in Alzheimer's disease course
| العنوان: | Sleep dysregulation, memory impairment, and CSF biomarkers during different levels of neurocognitive functioning in Alzheimer's disease course |
|---|---|
| المؤلفون: | Fabio Placidi, Claudio Liguori, Matteo Spanetta, Alessandra Di Pucchio, Nicola Biagio Mercuri, Francesca Izzi |
| المصدر: | Alzheimer's Research & Therapy Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Adult, Male, Sleep Wake Disorders, medicine.medical_specialty, Neurology, Cognitive Neuroscience, tau Proteins, Asymptomatic, lcsh:RC346-429, lcsh:RC321-571, Cerebrospinal fluid, Alzheimer Disease, Internal medicine, Medicine, Dementia, Memory impairment, Humans, Cognitive Dysfunction, Alzheimer's disease, CSF biomarkers, Sleep, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, Aged, Aged, 80 and over, Memory Disorders, Amyloid beta-Peptides, business.industry, Correction, Cognition, Middle Aged, medicine.disease, Sleep in non-human animals, Disease Progression, Settore MED/26 - Neurologia, Female, Neurology (clinical), medicine.symptom, business, Neurocognitive, Alzheimer’s disease, Biomarkers |
| الوصف: | Background Alzheimer's disease (AD) is frequently accompanied by sleep impairment, which can induce AD-related neurodegeneration. We herein investigated the sleep architecture, cognition, and cerebrospinal fluid (CSF) biomarkers (tau proteins and β-amyloid42) during AD progression from subjective cognitive impairment (SCI) to mild cognitive impairment (MCI) and eventually to AD dementia, and compared the results with cognitively normal (CN) subjects. Methods We included patients affected by SCI, MCI, mild AD, and moderate-to-severe AD in our study along with CN subjects as controls. All the subjects underwent nocturnal polysomnography to investigate sleep, neuropsychological testing to evaluate cognition, and lumbar puncture for CSF AD biomarkers assessment. Results Sleep (both rapid eye movement (REM) and non-REM sleep) and memory function are both progressively impaired during the course of AD from SCI to mild and subsequently to moderate AD. Further, sleep dysregulation appears earlier than cognitive deterioration, with a reduction of CSF β-amyloid42 level. Conclusion Sleep, memory, and CSF AD biomarkers are closely interrelated in AD progression from the earliest asymptomatic and preclinical stages of the disease related in AD since the earliest and preclinical stages of the disease. |
| تدمد: | 1758-9193 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d1f839263122dcf5592220d8eec67Test https://pubmed.ncbi.nlm.nih.gov/32384931Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be4d1f839263122dcf5592220d8eec67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17589193 |
|---|