Protective Effect of Acteoside on Ovariectomy-Induced Bone Loss in Mice
| العنوان: | Protective Effect of Acteoside on Ovariectomy-Induced Bone Loss in Mice |
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| المؤلفون: | Hunter Snooks, Xueqin Ma, Yanhong Dong, Li Nan, Li Yanting, Changling Hu, Jingjing Liu, Xiaojun Zhao, Lingling Yang, Bo Zhang |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 12, p 2974 (2019) International Journal of Molecular Sciences Volume 20 Issue 12 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Deoxypyridinoline, anti-osteoporotic, RANK, lcsh:Chemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Glucosides, Bone Density, Cathepsin K, lcsh:QH301-705.5, Spectroscopy, acteoside, Bone mineral, biology, Receptor Activator of Nuclear Factor-kappa B, RANKL, General Medicine, Organ Size, Computer Science Applications, 030220 oncology & carcinogenesis, Ovariectomized rat, Female, ovariectomized mice, TRAF6, medicine.medical_specialty, Ovariectomy, Protective Agents, Models, Biological, Catalysis, Bone resorption, Article, Bone and Bones, Inorganic Chemistry, 03 medical and health sciences, Phenols, Internal medicine, medicine, Animals, Physical and Theoretical Chemistry, Bone Resorption, Molecular Biology, Protein kinase B, TNF Receptor-Associated Factor 6, Organic Chemistry, Body Weight, RANK Ligand, biology.organism_classification, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), lcsh:QD1-999, Cistanche, biology.protein, Osteoporosis, Biomarkers |
| الوصف: | Acteoside, an active phenylethanoid glycoside compound isolated from herbs of Cistanche, was chosen for the investigation of anti-osteoporotic effect on postmenopausal osteoporosis by using an ovariectomized (OVX) mice model. The results from in vivo experiments showed that after daily oral administration of acteoside (20, 40, and 80 mg/kg body weight/day) for 12 weeks, bone mineral density and bone biomechanical properties of OVX mice were greatly enhanced, with significant improvement in bone microarchitecture. Furthermore, biochemical parameters of bone resorption markers as well as bone formation index, including tartrate-resistant acid phosphatase, cathepsin K, deoxypyridinoline, alkaline phosphatase, and bone gla-protein, were ameliorated by acteoside treatment, whereas the body, uterus, and vagina wet weights were seemingly not impacted by acteoside administration. Acteoside significantly affected osteoclastogenesis by attenuating nuclear factor kappa B (NF-&kappa B) and stimulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal pathways through down-regulated levels of tumor-necrosis factor receptor-associated factor 6 (TRAF6), receptor activator of nuclear factor kappa B ligand (RANKL), RANK, NFKBIA, I&kappa B kinase &beta nuclear factor of activated T-cells c2 (NFAT2), and up-regulated expressions of PI3K, AKT, and c-Fos. Accordingly, the current research validated our hypothesis that acteoside possesses potent anti-osteoporotic properties and may be a promising agent for the prevention of osteoporosis in the future. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49218851514de03a9f19ddbfb17dd31Test https://www.mdpi.com/1422-0067/20/12/2974Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a49218851514de03a9f19ddbfb17dd31 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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